Sealing stopper for a syringe and a prefilled syringe

• US 6,090,081 A
• Filed: 05/20/1998
• Issued: 07/18/2000
• Est. Priority Date: 05/22/1997
• Status: Expired due to Term

• Current Assignee: Daikyo Seiko, Ltd.
• Original Assignee: Daikyo Seiko, Ltd.
• Inventors: Sudo, Masamichi, Muraki, Tomoyasu
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US09/081,644
• Time in Patent Office: 790 Days
• Field of Search: 604/230, 604/218, 604/187
• US Class Current: 604/230
• CPC Class Codes: A61M 2205/0222 Materials for reducing friction
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: B29C 39/20 Making multilayered or multicoloured articles B29C39/142 takes precedence
• CPC Class Codes: B29K 2027/18 PTFE, i.e. polytetrafluorethene , e.g. ePTFE, i.e. expanded polytetrafluorethene
• CPC Class Codes: B29K 2995/0073 smooth
• CPC Class Codes: B29L 2031/7544 Injection needles, syringes

Abstract

There can be provided a sealing stopper for a syringe, having very high sealing property and sliding property, and a prefilled syringe using this sealing stopper and capable of preserving a medicament for a long time and operating in easy and precise manner during injecting. This syringe is also excellent in sanitary and operating property during a step of formulation or preservation of a medicament. In this sealing stopper for a syringe, a surface of the rubber body is laminated with a tetrafluoroethylene resin film or ultra-high molecular weight polyethylene film having an average roughness Ra on the central line of the surface in a range of at most 0.05 μm and a kinematic friction coefficient of at most 0.2.

Claims

1. A sealing stopper for a syringe, comprising a rubber body laminated with a tetrafluoroethylene resin film or ultra-high molecular weight polyethylene film having an average roughness Ra on the central line of a surface of said resin film or said poluethylene film in a range of at most 0.05 μ

m and a kinematic friction coefficient of at most 0.2.

2. A sealing stopper for a syringe, as claimed in claim 1, wherein the tetrafluoroethylene resin film is prepared by a casting-shaping method comprising using, as a raw material, a suspension containing tetrafluoroethylene resin powder having a grain diameter of at most 0.01 to 1.0 μ

m, a dispersing agent and a solvent.

3. The sealing stopper for a syringe, as claimed in claim 1, wherein said ultra-high molecular weight polyethylene film is prepared by an inflation shaping method or an extrusion shaping method.

4. A prefilled syringe, comprising an injection cylinder or two-component cylinder for enclosing or sealing a medicament, the medicament being enclosed or sealed by a sealing stopper for a syringe having a rubber body laminated with a tetrafluoroethylene resin film or ultrahigh molecular weight polyethylene film having an average roughness Ra on the central line of a surface of said resin film or said polyethylene film in a range of at most 0.05 μ

m and a kinematic friction coefficient of at most 0.2.