Short pulse mid-infrared laser source for surgery

• US 6,090,102 A
• Filed: 05/12/1997
• Issued: 07/18/2000
• Est. Priority Date: 05/12/1997
• Status: Expired due to Term

• Current Assignee: Amo Manufacturing Usa, Llc (Johnson & Johnson)
• Original Assignee: Irvision, Inc.
• Inventors: Telfair, William B., Hoffman, Hanna J.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): HARRIS, SONYA C
• Application Number:
  US08/854,565
• Time in Patent Office: 1,163 Days
• Field of Search: 606/2, 606/3, 606/4, 606/5, 606/6, 606/10, 606/11, 606/12, 606/13, 606/14, 606/15, 372/25, 372/26
• US Class Current: 606/10
• CPC Class Codes: A61F 2009/00872 Cornea
• CPC Class Codes: A61F 2009/00897 Scanning mechanisms or algorithms
• CPC Class Codes: A61F 9/008 using laser
• CPC Class Codes: A61F 9/00804 Refractive treatments
• CPC Class Codes: H01S 2302/00 Amplification / lasing wavelength
• CPC Class Codes: H01S 3/115 using intracavity electro-optic devices
• CPC Class Codes: H01S 3/1608 erbium
• CPC Class Codes: H01S 3/164 garnet

Abstract

A solid state laser source for surgical applications which produces short-pulse, mid-infrared radiation. Specifically, the laser preferably emits radiation near the absorption peak of water, with energy levels up to 20 mJ, pulse durations shorter than 50 ns and preferably shorter than 30 ns, with beam quality of less than 8 times the diffraction limit. The short pulses reduce unwanted thermal effects and changes in adjacent tissue to potentially sub-micron levels. The laser source produces pulse repetition rates in excess of 10 Hz when pumped by a flashlamp, but in a diode pumped embodiment, the repetition rate may exceed 30 Hz. Of particular interest is an erbium-doped YAG laser which is especially well suited to the needs of mid-infrared corneal ablation procedures for correcting refractive errors, when constructed according to principles disclosed by the invention.

Claims

1. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity operatively configured and adapted to produce a laser beam having a wavelength in the mid-infrared range, from about 2.5 to about 4.0 um, and which wavelength corresponds approximately to an absorption peak of said tissue, said laser rod being pumped by a pump source; and

an electro-optical Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is less than about 30 cm and sufficiently short to provide pulse durations shorter than 50 ns.

2. The laser system according to claim 1, wherein said laser rod is erbium-doped.

3. The laser system according to claim 2, wherein the erbium concentration of said rod is at about a 25-40% doping level.

4. The laser system according to claim 1, wherein the host of the active ion of said laser rod is comprised of YALO, YLF, YSGG or YAG.

5. The laser system according to claim 1, further comprising means for directing said laser beam onto said tissue to remove portions of said tissue primarily by a photo-mechanical ablation process.

6. The laser system according to claim 1, wherein an output coupling surface is coated onto one end of said laser rod.

7. The laser system according to claim 1, wherein said pump source is a flashlamp.

8. The laser system according to claim 1, wherein said pump source is a diode array.

9. The laser system according to claim 8, wherein said diode array pumps said laser rod in a side-pumped configuration.

10. The laser system according to claim 8, wherein said diode array pumps said laser rod in an end-pumped configuration.

11. The laser system according to claim 8, whereby an overall repetition rate of at least 20 Hz is achieved.

12. The laser system according to claim 1, wherein said pulses are produced at a repetition rate of at approximately 10 Hz.

13. The laser system according to claim 1, wherein said Q-switch is comprised of lithium niobate.

14. The laser system according to claim 1, wherein said surgical procedure is a corneal ablation procedure.

15. The laser system according to claim 14, wherein said corneal ablation procedure is based on a photospallation mechanism.

16. The laser system according to claim 14, wherein the fluence onto the eye is between 50 mJ/cm² and 200 mJ/cm².

17. The laser system according to claim 1, wherein said surgical procedure is an endoscopic procedure or a micro-surgical procedure.

18. The laser system according to claim 1, wherein a high reflecting surface is coated onto one end of said laser rod.

19. The laser system according to claim 1, wherein the resonator cavity is less than about 20 cm.

20. The laser system according to claim 1, wherein the hold-off voltage for producing the beam is less than about 2.5 KV.

21. The laser system according to claim 1, wherein the host of the active ion of said laser rod is selected from the group consisting of:

garnet, an oxide or a fluoride crystal.

22. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity operatively configured and adapted to produce a laser beam having a wavelength in the mid-infrared range approximately between about 2.7 and about 3.0, said laser rod being pumped by a pump source; and

an electro-optical Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is less than about 30 cm and sufficiently short to provide pulse durations shorter than 50 ns.

23. The laser system according to claim 22, wherein the resonator cavity is less than about 20 cm.

24. The laser system according to claim 22, wherein the hold-off voltage for producing the beam is less than about 2.5 KV.

25. A method for performing a laser surgical procedure on a tissue, said method comprising the steps of:

generating a laser beam in the mid-infrared range approximately between 2.79 and 3.02 μ

m;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns.

26. A method for performing a laser surgical procedure on a tissue, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns.

27. A method for removing corneal tissue from an eye of a patient, said method comprising the steps of:

generating a laser beam in the mid-infrared range approximately to an absorption peak of said corneal tissue;

oscillating said beam in a resonator cavity;

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns; and

directing said beam across an area of said corneal tissue in a predefined pattern to remove portions of said corneal tissue primarily by a photo-mechanical ablation process.

28. A mid-infrared laser system for removing corneal tissue from any eye of a patient, said system comprising:

a laser resonator cavity;

a laser rod within said cavity operatively configured and adapted to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said corneal tissue, said laser rod being pumped by a pump source;

an electro-optical Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns; and

means for directing said laser beam onto said eye in a pre-defined pattern to remove portions of said corneal tissue primarily by a photo-mechanical ablation process.

29. The laser system according to claim 28, wherein the resonator cavity is less than about 30 cm.

30. The laser system according to claim 28, wherein the resonator cavity is less than about 20 cm.

31. The laser system according to claim 28, wherein the hold-off voltage for producing the beam is less than about 2.5 KV.

32. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity, said laser rod being pumped by a pump source to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said tissue; and

a Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and wherein the ends of said laser rod are cut at the Brewster angle.

33. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity, said laser rod being pumped by a pump source to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said tissue; and

a Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is less than about 30 cm and sufficiently short to provide pulse durations shorter than 50 ns and wherein the ends of said Q-switch material are cut at the Brewster angle.

34. The laser system according to claim 33, wherein the resonator cavity is less than about 20 cm.

35. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity, said laser rod being pumped by a pump source to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said tissue; and

a Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and wherein said pump source is a diode array, and wherein said diode array pumps said laser rod in an end-pumped configuration, and wherein said laser rod is comprised of a plurality of sections N, each end-pumped individually, whereby an overall repetition rate of at least 20 Hz*N is achieved in a laser beam combined by a beam delivery system.

36. A method for performing a laser surgical procedure on a tissue, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is less than about 30 cm and sufficiently short to provide pulse durations shorter than 50 ns and wherein said laser rod is erbium-doped.

37. The laser system according to claim 36, wherein the resonator cavity is less than about 20 cm.

38. A method for performing a laser surgical procedure on a tissue, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns;

directing said laser beam onto said tissue to remove portions of said tissue primarily by a photo-mechanical ablation process.

39. A method for performing a laser surgical procedure on a tissue, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and the pulses are produced at a repetition rate of at least approximately 10 Hz.

40. A method for performing a laser surgical procedure on a tissue, said procedure being selected from the group consisting of:

a corneal ablation procedure, an endoscopic procedure and a micro-ocular procedure, said method comprising the steps of;

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is less than about 30 cm and sufficiently short to provide pulse durations shorter than 50 ns.

41. The laser system according to claim 40, wherein the resonator cavity is less than about 20 cm.

42. A method for performing a corneal ablation procedure based on a photospallation mechanism, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is less than about 30 cm and sufficiently short to provide pulse durations shorter than 50 ns.

43. The laser system according to claim 42, wherein the resonator cavity is less than about 20 cm.

44. A method for performing a corneal ablation procedure based on a photospallation mechanism, wherein the fluence onto the eye is between 50 mJ/cm² and 200 mJ/cm², said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns.

45. A method for performing a laser surgical procedure on a tissue, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using a laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam;

wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and the hold-off voltage for generating the laser beam is less than about 2.5 KV.

46. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity, said laser rod being pumped by a pump source to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said tissue; and

a Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and wherein the hold-off voltage for generating the laser beam is less than about 2.5 KV.

47. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity, said laser rod being pumped by a pump source to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said tissue; and

a Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and wherein pulses are produced at a repetition rate of at least approximately 10 Hz.

48. A mid-infrared laser system for performing a laser surgical procedure on a tissue, said system comprising:

a laser resonator cavity;

a laser rod within said cavity, said laser rod being pumped by a pump source to produce a laser beam having a wavelength in the mid-infrared range corresponding approximately to an absorption peak of said tissue; and

a Q-switch to control the oscillation of said laser beam within the resonator cavity to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 50 ns and wherein said pump source is a diode array.

49. A method for performing a corneal ablation procedure based on a photospallation mechanism, wherein the fluence onto the eye is between 50 mJ/cm² and 200 mJ/cm², said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 70 ns.

50. A method for performing a corneal ablation procedure based on a photospallation mechanism, wherein the threshold fluence for obtaining ablation less than about 100 mJ/cm², said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 70 ns.

51. A method for performing a corneal ablation procedure based on a photospallation mechanism, wherein the thermal damage zone generated by the ablation procedure is less than 2 um, said method comprising the steps of:

generating a laser beam in the mid-infrared range corresponding approximately to an absorption peak of said tissue using an erbium-doped laser rod;

oscillating said beam in a resonator cavity; and

controlling said oscillation using a Q-switch to produce pulses of said laser beam, wherein the length of said resonator cavity is sufficiently short to provide pulse durations shorter than 70 ns.