Potentiation of immune responses with liposomal adjuvants
First Claim
1. A method of potentiating an immune response in an animal which comprises administering to the animal a dosage form comprising:
- (a) a liposome which comprises;
(i) a lipid consisting essentially of an organic acid derivative of a sterol; and
,(ii) an antigenic peptide; and
,(b) a pharmaceutically acceptable carrier,wherein said organic acid is selected from the group consisting of a carboxylic, dicarboxylic, polycarboxylic, hydroxy, amino and polyamino acid attached to said sterol at a hydroxyl group by an ether or ester linkage, and wherein the liposome is present in the dosage form in an immunization dose.
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Accused Products
Abstract
A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.
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Citations
16 Claims
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1. A method of potentiating an immune response in an animal which comprises administering to the animal a dosage form comprising:
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(a) a liposome which comprises; (i) a lipid consisting essentially of an organic acid derivative of a sterol; and
,(ii) an antigenic peptide; and
,(b) a pharmaceutically acceptable carrier, wherein said organic acid is selected from the group consisting of a carboxylic, dicarboxylic, polycarboxylic, hydroxy, amino and polyamino acid attached to said sterol at a hydroxyl group by an ether or ester linkage, and wherein the liposome is present in the dosage form in an immunization dose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification