Method of calibration and real-time analysis of particulates
First Claim
1. A method of analyzing particles for a plurality of species, comprising the steps of:
- (a) providing;
(i) a plurality of morphology types;
(ii) a plurality of spectrum types;
(iii) a plurality of target classes, each of said target classes corresponding to one of said morphology types and one of said spectrum types, and(iv) a relationship between a descriptor vector and a concentration vector, said descriptor vector including a plurality of elements, each element of said descriptor vector corresponding to a different one of said target classes, said concentration vector including a plurality of elements, each element of said concentration vector corresponding to a different one of the species;
(b) acquiring a plurality of images of the particles, each of said images being acquired at a different wavelength;
(c) inferring said descriptor vector from said plurality of images; and
(d) using said relationship to infer said concentration vector from said descriptor vector.
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Abstract
A method of analyzing particles for chemical or biological species. Spectral images of the particles are acquired. Targets are identified in the images and are classified according to morphology type and spectrum type. Each target is assigned a value of an extensive property. A descriptor vector is formed, each element of the descriptor vector being the sum of the extensive property values for one target class. The descriptor vector is transformed to a vector of mass concentrations of chemical species of interest, or of number concentrations of biological species of interest, using a relationship determined in a calibration procedure. In the calibration procedure, spectral images of calibration samples of known composition are acquired, and empirical morphology types and spectrum types are inferred from the spectral images. Targets are identified in the spectral images, classified according to morphology type and spectrum type, and assigned values of an extensive property. For each calibration sample, a calibration descriptor vector and a calibration concentration vector is formed. A collective relationship between the calibration descriptor vectors and the calibration concentration vectors is found, either by multivariate analysis or by training a neural network.
48 Citations
23 Claims
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1. A method of analyzing particles for a plurality of species, comprising the steps of:
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(a) providing; (i) a plurality of morphology types; (ii) a plurality of spectrum types; (iii) a plurality of target classes, each of said target classes corresponding to one of said morphology types and one of said spectrum types, and (iv) a relationship between a descriptor vector and a concentration vector, said descriptor vector including a plurality of elements, each element of said descriptor vector corresponding to a different one of said target classes, said concentration vector including a plurality of elements, each element of said concentration vector corresponding to a different one of the species; (b) acquiring a plurality of images of the particles, each of said images being acquired at a different wavelength; (c) inferring said descriptor vector from said plurality of images; and (d) using said relationship to infer said concentration vector from said descriptor vector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification