Subdural electrode arrays for monitoring cortical electrical activity

• US 6,091,979 A
• Filed: 07/07/1998
• Issued: 07/18/2000
• Est. Priority Date: 07/07/1998
• Status: Expired due to Fees

• Current Assignee: Children's Medical Center Corporation
• Original Assignee: Children's Medical Center Corporation
• Inventors: Madsen, Joseph R.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): RUDDY, DAVID M
• Application Number:
  US09/111,328
• Time in Patent Office: 742 Days
• Field of Search: 600/372-378, 600/393, 600/544, 607/116, 607/117, 607/118, 607/119, 607/122, 607/129-141, 607/152, 607/11
• US Class Current: 600/377
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/293 Invasive
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy

Abstract

Electrodes arrays for monitoring in vivo electrical activity are disclosed. The arrays include a plurality of electrode contact pads in a predetermined spatial orientation held together by a structural matrix material that is preferably bioresorbable. The electrode pads are connected via lead wires to monitoring, analysis, and recording apparatus. The electrode arrays can be individually prepared, and configured (e.g., by irregular spacing between the electrode contact pads) to conform to the region undergoing analysis. Because the matrix material is substantially resorbed in the course of the protocol, the individual electrode cables will no long be attached to each other (or in the case of branching electrodes, the branches will no longer be fixed in position). In either instance, the electrode cables (or trunk and branches) can be removed without a second major operation.

Claims

1. An electrode array for cranial implantation comprising:

a plurality of electrode cables for detection of electrical activity in a patient'"'"'s body following implantation, and

a bioresorbable material connected to the plurality of electrode cables, for maintaining thc cables in an initial predetermined spatial relationship and having a degradation period that corresponds with the period of intended use of the array to facilitate removal of the array.

2. An electrode array as in claim 1, wherein the electrode cables comprise at least one electrode contact pad disposed within each cable, an electrode lead wire disposed within the electrode cable, and the electrode lead wire being in electrical communication with the electrode contact pad.

3. A electrode array as in claim 2 wherein the electrode contact pad is dimensioned such that the cross sectional area of the electrode cable is substantially smooth.

4. A electrode array as in claim 1 wherein the electrode cable is coated with a low friction surface material.

5. A electrode array as in claim 4 wherein the low friction coating material is a lubricating polymer selected from the group of hyaluronic acids, glycosaminoglycans and derivatives thereof.

6. A electrode array as in claim 1 wherein the electrode cable is comprised of a fluorocarbon.

7. A electrode as in claim 6 wherein the fluorocarbon is selected from the group consisting of polytetrafluoroethylene (PTFE) fluorinated ethylene propylene (FEP), perfluroalkoxy (PFA) and tetraethylenepropylene (TFP).

8. The electrode array as in claim 7 wherein the fluorocarbon is PTFE.

9. A electrode array as in claim 1 wherein the bioresorbable material is a hemostatic substance.

10. A electrode array as in claim 1 wherein the bioresorbable material is selected from the group of collagen, oxidized cellulose, poly-L-lactic acid, polylactic-coglycolic acid polymers, polycaprolactone and derivatives and combinations thereof.

11. A electrode array for cranial implantation comprising:

at least one electrode cable having a branching structure for detection of electrical activity in a patient'"'"'s body following implantation, and

a bioresorbable material connected to the branching structure of the electrode cable, for maintaining the cables in an initial predetermined spatial relationship and having a degradation period that corresponds with the period of intended use of the array to facilitate removal of the array,

whereby after the bioresorbable material is reabsorbed, said at least one electrode cable may be withdrawn percutaneously.

12. A electrode array as in claim 11 wherein the branching structure comprises:

a trunk electrode cable having at least one electrode contact pad disposed within the trunk electrode cable and an electrode lead wire disposed within the trunk electrode cable and in electrical communication with the electrode contact pad,

at least one branch electrode cable, the branch electrode having at least one electrode pad disposed within the branch electrode cable and an electrode lead wire disposed within the first branch electrode cable in electrical communication with the electrode pad,

the branch electrode cable being affixed to the trunk electrode cable, and communications therewith, such that the branch electrode cable makes an angle with the trunk electrode of between 90° and

-90°

.

13. A electrode array as in claim 12 wherein the branch electrode cable is coated with a low friction surface material.

14. A electrode array as in claim 13 wherein the low friction coating material is a lubricating polymer selected from the group of hyaluronic acids, glycosaminoglycans and derivatives thereof.

15. The electrode array as in claim 11 wherein the electrode cable is comprised of a fluorocarbon.

16. The electrode array as in claim 15 wherein the fluorocarbon is PTFE.

17. The electrode array as in claim 16 wherein the fluorocarbon is FEP.

18. The electrode array as in claim 16 wherein the fluorocarbon is PFA.

19. The electrode array as in claim 16 wherein the fluorocarbon is TFP.

20. A electrode array as in claim 11 wherein the bioresorbable material is a hemostatic substance.

21. A electrode array as in claim 11 wherein the bioresorbable material is selected from the group of collagen, oxidized cellulose, poly-L-lactic acid, polylactic-coglycolic acid polymers, polycaprolactone and derivatives and combinations thereof.