Intraparenchymal infusion catheter system

• US 6,093,180 A
• Filed: 08/18/1997
• Issued: 07/25/2000
• Est. Priority Date: 04/28/1995
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Elsberry, Dennis D.
• Primary Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/912,379
• Time in Patent Office: 1,072 Days
• Field of Search: 604/8, 604/9, 604/19, 604/20, 604/48, 604/508, 604/510, 604/514, 604/515, 604/516, 604/517, 604/73, 604/93, 604/117, 604/123, 604/131, 604/151-153, 604/264-266, 604/275 , 604/523, 604/892.1, 604/506, 604/528, 604/530, 604/531, 604/533, 604/534-536, 128/DIG. 12, 128/898
• US Class Current: 604/506
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/001 Forming the tip of a catheter, e.g. bevelling process, join or taper
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0069 Tip not integral with tube
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular portion terminating in a free distal end. The distal end of the catheter bears a rounded tip, a portion of which is slidably disposed within the lumen of the tubular portion. The tip is porous for discharging an agent or drug to a selected site. The tip has a microporosity of less than or equal to 0.22 microns. The tubular portion is composed from a material that will expand from its nominal size when exposed to a stimulus such as heat or a solvent and return to its nominal size when the stimulus is withdrawn. By expanding the tubular portion, a physician can select the amount of the tip that is exposed to the organism, thereby customizing the catheter to the structural size of the selected site within the body.

Claims

1. A method of delivering a therapeutic agent to a selected site within brain tissue of an organism utilizing a catheter comprising a first tubular portion that has a lumen and a second tubular portion partially disposed within the lumen, comprising the steps of:

a) adjusting the length of the second tubular portion to conform to the dimensions of a selected site in an organism;

b) placing the catheter in the organism so that the second tubular portion is placed at the selected site;

c) coupling the catheter to a pump for delivering therapeutic agent to the site; and

d) actuating the pump to deliver the therapeutic agent to the site.

2. The method of claim 1 wherein the step of adjusting the length of the second tubular portion comprises the steps of:

a) heating the first tubular portion until the diameter of the lumen increases in diameter a sufficient amount to enable relative sliding movement between the first tubular portion and the second tubular portion;

b) sliding the second tubular portion in the lumen relative to the first tubular portion to provide a preselected length of the second tubular portion that extending distally beyond the distal end of the first tubular portion; and

c) cooling the first tubular portion until the first tubular portion and the second tubular portion are no longer capable of relative sliding movement.

3. The method of claim 1 wherein the step of adjusting the length of the second tubular portion comprises the steps of:

a) exposing the first tubular portion to a solvent that increases the diameter of the lumen a sufficient amount to permit relative sliding movement of the second tubular portion in the lumen;

b) sliding the second tubular portion in the lumen to obtain a preselected length of the second tubular portion extending distally beyond the distal end of the first tubular portion; and

c) ceasing to expose the first tubular portion to the solvent whereby the diameter of the first tubular portion decreases until relative sliding movement between the first tubular portion and the second tubular portion is prevented.

4. The method of claim 1 wherein the tissue comprises a malignant mass.

5. A method of delivering a therapeutic agent to a selected site within an organism utilizing a catheter comprising a first tubular portion that has a lumen and a second tubular portion partially disposed within the lumen, comprising the steps of:

a) adjusting the length of the second tubular portion to conform to the dimensions of a selected site in an organism according to the steps of;

1) heating the first tubular portion until the diameter of the lumen increases in diameter a sufficient amount to enable relative sliding movement between the first tubular portion and the second tubular portion;

2) sliding the second tubular portion in the lumen relative to the first tubular portion to provide a preselected length of the second tubular portion that extending distally beyond the distal end of the first tubular portion; and

3) cooling the first tubular portion until the first tubular portion and the second tubular portion are no longer capable of relative sliding movement;

b) placing the catheter in the organism so that the second tubular portion is placed at the selected site;

c) coupling the catheter to a pump for delivering therapeutic agent to the site; and

d) actuating the pump to deliver the therapeutic agent to the site.

6. A method of delivering a therapeutic agent to a selected site within an organism utilizing a catheter comprising a first tubular portion that has a lumen and a second tubular portion partially disposed within the lumen, comprising the steps of:

a) adjusting the length of the second tubular portion to conform to the dimensions of a selected site in an organism according to the steps of;

1) exposing the first tubular portion to a solvent that increases the diameter of the lumen a sufficient amount to permit relative sliding movement of the second tubular portion in the lumen;

2) sliding the second tubular portion in the lumen to obtain a preselected length of the second tubular portion extending distally beyond the distal end of the first tubular portion; and

3) ceasing to expose the first tubular portion to the solvent whereby the diameter of the first tubular portion decreases until relative sliding movement between the first tubular portion and the second tubular portion is prevented;

b) placing the catheter in the organism so that the second tubular portion is placed at the selected site;

c) coupling the catheter to a pump for delivering therapeutic agent to the site; and

d) actuating the pump to deliver the therapeutic agent to the site.

7. A method of delivering a therapeutic agent to a selected site within tissue of an organism utilizing a catheter comprising a first tubular portion that has a lumen and a second tubular portion partially disposed within the lumen, comprising the steps of:

a) adjusting the length of the second tubular portion to conform to the dimensions of a selected site in an organism according to the steps of;

1) heating the first tubular portion until the diameter of the lumen increases in diameter a sufficient amount to enable relative sliding movement between the first tubular portion and the second tubular portion;

2) sliding the second tubular portion in the lumen relative to the first tubular portion to provide a preselected length of the second tubular portion that extending distally beyond the distal end of the first tubular portion; and

3) cooling the first tubular portion until the first tubular portion and the second tubular portion are no longer capable of relative sliding movement;

b) placing the catheter in the organism so that the second tubular portion is placed at the selected site;

c) coupling the catheter to a pump for delivering therapeutic agent to the site; and

d) actuating the pump to deliver the therapeutic agent to the site.

8. A method of delivering a therapeutic agent to a selected site within tissue of an organism utilizing a catheter comprising a first tubular portion that has a lumen and a second tubular portion partially disposed within the lumen, comprising the steps of:

a) adjusting the length of the second tubular portion to conform to the dimensions of a selected site in an organism according to the steps of;

1) exposing the first tubular portion to a solvent that increases the diameter of the lumen a sufficient amount to permit relative sliding movement of the second tubular portion in the lumen;

2) sliding the second tubular portion in the lumen to obtain a preselected length of the second tubular portion extending distally beyond the distal end of the first tubular portion; and

3) ceasing to expose the first tubular portion to the solvent whereby the diameter of the first tubular portion decreases until relative sliding movement between the first tubular portion and the second tubular portion is prevented;

b) placing the catheter in the organism so that the second tubular portion is placed at the selected site;

c) coupling the catheter to a pump for delivering therapeutic agent to the site; and

d) actuating the pump to deliver the therapeutic agent to the site.