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Miniaturized planar columns in novel support media for liquid phase analysis

  • US 6,093,362 A
  • Filed: 02/11/1999
  • Issued: 07/25/2000
  • Est. Priority Date: 10/19/1994
  • Status: Expired due to Term
First Claim
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1. A method of forming a plurality of identical miniaturized column devices, comprising the steps of:

  • (a) providing a master support body having a substantially planar interior surface, wherein the master support body is comprised of a material other than silicon and silicon dioxide;

    (b) forming a master copy of a miniaturized column device by;

    forming a microchannel directly in the interior surface of the master support body;

    (c) forming a mold insert by;

    (i) coating the interior surface of the master copy with a layer of a metal;

    (ii) depositing a metal thereon to fill the microchannel formed in the interior surface; and

    (iii) separating the mold insert from the master support body, whereby a mold insert is provided; and

    (d) preparing additional miniaturized column devices identical to the master copy by filling the mold insert with a suitable polymeric or ceramic material, whereby a miniaturized column device thus formed can be covered with a plate over the microchannel of the additional miniaturized column device to form a device having a microchannel for a fluid to pass therethrough.

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