Modulation of the sensitivity of tumor cells to chemotherapeutics
First Claim
1. A method for improving the activity of cancer chemotherapeutic agents which comprises:
- (a) combining said chemotherapeutic agent with one or more of(i) lymph node lymphocytes which have been cultured under mitogenic stimulation conditions, or(ii) supernatant of said mitogenically stimulated cultured lymph node lymphocytes,wherein said lymph node lymphocytes that are cultured under said mitogenic stimulation conditions are cancer patient excised lymph node lymphocytes enriched in tumor reactive cells, and(b) administering such combination to said cancer patient.
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Abstract
Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the patient is administered mitogenically stimulated lymph node lymphocytes or the supernatant therefrom. The lymph node lymphocytes are patient excised lymph node lymphocytes enriched in tumor reactive cells, such as CD4+ tumor reactive cells. Radiolabeled locators (e.g., antibodies) can be used along with a portable radiation detector to intraoperatively determine which lymph nodes bear lymph node lymphocytes enriched in tumor reactive cells. The patient excised lymph node lymphocytes enriched in tumor reactive cells then are subjected to mitogenic stimulation for their expansion and administration to the patient.
23 Citations
20 Claims
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1. A method for improving the activity of cancer chemotherapeutic agents which comprises:
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(a) combining said chemotherapeutic agent with one or more of (i) lymph node lymphocytes which have been cultured under mitogenic stimulation conditions, or (ii) supernatant of said mitogenically stimulated cultured lymph node lymphocytes, wherein said lymph node lymphocytes that are cultured under said mitogenic stimulation conditions are cancer patient excised lymph node lymphocytes enriched in tumor reactive cells, and (b) administering such combination to said cancer patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for improving the treatment of a cancer patient which is undergoing chemotherapeutic treatment with a chemotherapeutic agent, which comprises:
- co-administering said chemotherapeutic agent to said patient along with one or more of;
(i) lymph node lymphocytes which have been cultured under mitogenic stimulation conditions, or (ii) supernatant of said mitogenically stimulated cultured lymph node lymphocytes, wherein said lymph node lymphocytes that are cultured under said mitogenic stimulation conditions are cancer patient excised lymph node lymphocytes enriched in tumor reactive cells. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
- co-administering said chemotherapeutic agent to said patient along with one or more of;
Specification