Isotope seeding system that releases radioactive seeds for treatment of cancerous cells

• US 6,095,967 A
• Filed: 03/25/1998
• Issued: 08/01/2000
• Est. Priority Date: 03/25/1998
• Status: Expired due to Term

• Current Assignee: Surgical Specialties Corporation Limited (Ssc Holdco Ltd)
• Original Assignee: Manan Medical Products, Inc.
• Inventors: Black, Wayne J., Mittermeier, Manfred
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): Kearney, R.
• Application Number:
  US09/047,715
• Time in Patent Office: 860 Days
• Field of Search: 600/7, 600/8, 604/57, 604/59, 604/60, 604/61, 604/62, 604/63, 604/64, 604/44, 604/20
• US Class Current: 600/7
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

An isotope seeding system that controls the release of radioactive seeds for treatment of cancerous cells during cancer treatment procedures. The isotope seeding system comprises at least one seed that is chargeable with radioactive isotopes. At least one dissolvable web netting may alternatively be positioned about the at least one seed, and a seed deployment assembly is utilized for delivering the at least one seed, with or without the dissolvable web netting, into an organism'"'"'s tissue, to surround cancerous cells. The seed deployment assembly includes an elongated cannula, a hub assembly and an obturator. The hub assembly includes an initial inner diameter at its proximal end and an operable length between the proximal end of the hub assembly and the proximal end of the cannula, the ratio of the initial inner diameter relative to the operable length being in the range of 0.075 to 0.175, to preclude against jamming of the at least one seed, with or without the at least one dissolvable web netting wrapped thereabout, within the hub assembly and/or to further preclude against inadvertent migration of such seeds from the web netting when such netting is utilized.

Claims

1. An isotope seeding system that controls the release of radioactive seeds for treatment of cancerous cells to preclude against jamming and inadvertent migration of said radioactive seeds curing cancer treatment procedures, said system comprising:

at least one seed that is chargeable with radioactive isotopes;

a seed deployment assembly for locating and delivering said at least one seed into the tissue of an organism, proximate to said cancerous cells;

said deployment assembly including an elongated cannula having a proximal and a distal end, said distal end opposite said proximal end and a conduit positioned therebetween;

a hub assembly attached to the elongated cannula at the proximal end of said cannula, the hub assembly including a proximal and distal end, and an interior region, said distal end of said hub assembly operably associated with the proximal end of said elongated cannula for staging and directing said at least one seed through said elongated cannula from said cannula proximal end to said cannula distal end and, in turn, into said tissue at a desired location proximate said cancerous cells;

an obturator for telescopic projection of said at least one seed through both said hub assembly and said elongated cannula; and

said hub assembly having an initial inner diameter at its proximal end and an operable length between said proximal end of said hub assembly and said proximal end of said cannula, said ratio of said initial inner diameter at the proximal end of said hub assembly, relative to the operable length of said hub assembly, being in the range of 0.075 to 0.175, to ensure against the inadvertent migration and jamming of said at least one seed in said hub assembly; and

the interior region of said hub assembly including a first substantially conical section having a length and a second substantially conical section having a length, the length of the first conical section being at least 50% of the combined length of the first and second conical sections.

2. The invention of claim 1 in which said system further comprises at least one dissolvable web netting operably associated with and positioned about said at least one seed for housing and maintaining the at least one seed in a substantially linear arrangement prior to positioning and arrangement of said at least one dissolvable web netting and, in turn, said at least one seed positioned therewithin, about selected ones of said cancerous cells, said seed deployment assembly further locating and delivering said at least one seed and said at least one dissolvable web netting positioned thereabout into said organism'"'"'s tissue, proximate to said cancerous cells, in which both said at least one seed and at least one dissolvable web netting are staged and directed through said hub assembly by said obturator towards the projected release of both from the distal end of said elongated cannula.

3. The system according to claim 1 wherein the first substantially conical section includes a first conical proximal and distal end, said first conical section tapering inwardly from said first conical proximal end to said first conical distal end, and the second, distinct substantially conical section operably positioned between said distal end of said first conical section and said proximal end of said elongated cannula, said first conical section tapering inwardly from said first conical proximal end toward said first conical distal end to define a substantially continuous first slope, said first slope not exceeding 1°

30'"'"'.

4. The system according to claim 3 wherein the first conical section extends from said proximal end of said hub assembly for at least half of the operable length of said hub assembly.

5. The system according to claim 3 wherein the second conical section includes a substantially continuous second slope tapering inwardly between said distal end of said first conical section and said proximal end of said elongated cannula, said second slope not less than 7°

30'"'"'.

6. The system according to claim 5 wherein said length of said second conical section extends for less than half of the operable length of said hub assembly.

7. The system according to claim 1 wherein said elongated cannula comprises an 18 gauge cannula member.

8. The system according to claim 1 wherein said elongated cannula includes a stylus, said stylus being positioned at the distal end of said elongated cannula, said stylus facilitates insertion of the elongated cannula into said organism'"'"'s tissue.

9. The system according to claim 1 wherein the distal end of said hub assembly telescopically receives and secures the proximal end of said cannula therewithin.

10. The system according to claim 1 wherein the elongated cannula includes equidistantly-spaced, radiologically visible markings for denominating divisions of length.

11. The system according to claim 1 wherein the obturator includes equidistantly-spaced, radiologically visible markings for denominating divisions of length.

12. The system according to claim 1 wherein the length of the obturator is at least as long as the collective length of said elongated cannula and said hub assembly.

13. The system according to claim 1 wherein the outer surface of said hub assembly is substantially rectangular.

14. The system according to claim 1 wherein the hub assembly is formed of a plastic material.

15. The system according to claim 1 wherein said hub assembly has an initial inner diameter at its proximal end and an operable length between said proximal end of said hub assembly and said proximal end of said cannula, said ratio of said initial inner diameter at the proximal end of said hub assembly, relative to the operable length of said hub assembly, being in the range of 0.075 to 0.175, to ensure against the inadvertent migration and jamming of said at least one seed in said hub assembly.

16. The system according to claim 1 wherein the length of the first substantially conical section ranges between 75% to 85% of the combined length of the first and second conical sections.