Pulse inversion doppler ultrasonic diagnostic imaging

• US 6,095,980 A
• Filed: 09/17/1998
• Issued: 08/01/2000
• Est. Priority Date: 10/02/1997
• Status: Expired due to Term

• Current Assignee: Sunnybrook Health Sciences Centre
• Original Assignee: Sunnybrook Health Sciences Centre
• Inventors: Hope-Simpson, David, Burns, Peter N.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US09/156,097
• Time in Patent Office: 684 Days
• Field of Search: 600/443, 600/447, 600/453, 600/458, 600/454-456
• US Class Current: 600/453
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: G01S 15/104 wherein the transmitted pulses use a frequency- or phase-modulated carrier wave
• CPC Class Codes: G01S 15/8959 using coded signals for correlation purposes
• CPC Class Codes: G01S 15/8963 using pulse inversion
• CPC Class Codes: G01S 15/8981 Discriminating between fixed and moving objects or between objects moving at different speeds, e.g. wall clutter filter
• CPC Class Codes: G01S 7/52036 using analysis of echo signal for target characterisation
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target
• CPC Class Codes: G01S 7/52039 exploiting the non-linear response of a contrast enhancer, e.g. a contrast agent diagnostic techniques involving the use of contrast agents A61B8/481
• CPC Class Codes: G01S 7/52068 Stereoscopic displays; Three-dimensional displays; Pseudo 3D displays G01S15/8993 takes precedence
• CPC Class Codes: G01S 7/52069 Grey-scale displays

Abstract

An ultrasonic diagnostic imaging method and apparatus are presented which separates broadband linear and nonlinear echo signal components while simultaneously distinguishing the effects of motion. The inventive method maps ultrasonic echo signals in the r.f. (time) domain to Doppler shift frequencies in the Doppler domain in a way that depends upon the linearity of the echoes. The inventive method does this by analyzing the phase shifts between successive echoes. Apparatus is described in which a Doppler echo ensemble is acquired by a transmit sequence of cyclically phase-varying waveforms. When the echoes of the ensemble are combined during Doppler processing, the resulting Doppler spectrum is divided into separate regions, with odd harmonics (e.g., linear signal components) residing in one region and even harmonics (e.g., second harmonic signal components) residing in another region. In a preferred embodiment a Doppler wall filter is used to delineate a particular type of signal information for processing, such as tissue motion, harmonic contrast agent, or tissue harmonic imaging information.

Claims

1. A method for ultrasonically analyzing linear or nonlinear ultrasonic echo signal components comprising the steps of:

transmitting a sequence of phase-varying ultrasonic waves into the body;

receiving a sequence of ultrasonic echo signals in response to said phase-varying ultrasonic waves;

analyzing the phase shifts between successive echoes to separate the phase shifts of odd and even harmonic signal components; and

utilizing at least one of said separate odd and even harmonic signal components.

2. The method of claim 1, wherein said step of transmitting comprises transmitting a sequence of ultrasonic waves which vary in phase by 180°

from one wave to the next.

3. The method of claim 1, wherein said step of analyzing comprises Doppler processing said sequence of ultrasonic echo signals.

4. The method of claim 3, wherein said step of Doppler processing includes filtering Doppler shift signals with a predetermined filter characteristic.

5. The method of claim 1, wherein said step of utilizing comprises producing an ultrasonic image using said separated harmonic signal components.

6. The method of claim 1, wherein said step of utilizing comprises displaying a quantified Doppler measurement using said separated harmonic signal components.

7. The method of claim 1, wherein said step of receiving comprises receiving a sequence of temporally distinct echoes from a given target location.

8. The ultrasonic diagnostic imaging system of claim 1, wherein said sequence of ultrasonic echo signals comprises a sequence of three or more echo signals.

9. A method for mapping r.f. ultrasonic echo signal information to the Doppler domain in a manner which separates linear and nonlinear signal information comprising the steps of:

transmitting a sequence of phase-varying ultrasonic waves into the body;

receiving an ensemble of ultrasonic echo signals in response to said phase-varying ultrasonic waves; and

Doppler processing said ensemble of echo signals to produce Doppler phase shift information separated in accordance with the linearity of the echo signals.

10. The method of claim 9 wherein said step of transmitting comprises transmitting a sequence of ultrasonic waves which vary in phase by 180°

from one wave to the next.

11. The method of claim 10, wherein said step of Doppler processing includes filtering Doppler shift signals with a predetermined filter characteristic.

12. The method of claim 11, wherein said step of filtering comprises wall filtering said ultrasonic echo signals.

13. The method of claim 9, wherein said step of receiving comprises receiving an ensemble of temporally distinct echoes from a given target location.

14. The method of claim 9, wherein said step of Doppler processing comprises Doppler processing an ensemble of echo signals from tissue.

15. The method of claim 9, wherein said step of Doppler processing comprises Doppler processing an ensemble of echo signals from moving tissue.

16. The method of claim 9, wherein said step of Doppler processing comprises Doppler processing an ensemble of echo signals from tissue which contain second harmonic signal components.

17. The method of claim 9, wherein said step of Doppler processing comprises Doppler processing said ensemble of echo signals to produce velocity information.

18. The method of claim 9, wherein said step of Doppler processing comprises Doppler processing said ensemble of echo signals to produce power Doppler information.

19. A method for differentiating linear and nonlinear ultrasonic echo signal components comprising the steps of:

transmitting a modulated sequence of three or more ultrasonic waves into the body to generate phase distinctions in resulting ultrasonic echoes;

receiving an ensemble of three or more ultrasonic echo signals in response to said transmitted sequence; and

analyzing said ensemble of echo signals to separate phase shift information of linear and nonlinear echo signal components in the presence of motion.

20. The method of claim 19, wherein said step of transmitting comprises transmitting ultrasonic waves which are modulated from pulse to pulse.

21. The method of claim 20, wherein said transmit pulse modulation introduces a phase separation between linear and nonlinear signal components.

22. The method of claim 20, wherein said modulation occurs at the Nyquist limit of the rate of said transmit pulses.

23. The method of claim 20, wherein said modulation comprises a 180°

phase variation from pulse to pulse, an amplitude modulation from pulse to pulse, or a combination of phase and amplitude modulation from pulse to pulse.

24. The method of claim 19, wherein said step of analyzing comprises differentially detecting linear and nonlinear signal components.

25. The method of claim 24, wherein said step of differentially detecting comprises power Doppler processing said ensemble.

26. The method of claim 24, wherein said step of differentially detecting comprises colorflow processing said ensemble.

27. A method for differentially phase modulating linear and nonlinear ultrasonic echo signal components comprising the steps of:

transmitting a modulated sequence of ultrasonic waves into the body to generate phase distinctions in resulting ultrasonic echoes;

receiving an ensemble of ultrasonic echo signals in response to said transmitted sequence; and

analyzing said ensemble to separate phase shift information of linear and nonlinear signal components,

wherein said step of transmitting comprises transmitting ultrasonic waves which are modulated from pulse to pulse,

wherein said modulation comprises a 180°

phase variation from pulse to pulse, an amplitude modulation from pulse to pulse, or a combination of phase and amplitude modulation from pulse to pulse, and

wherein said step of analyzing comprises Doppler processing said ensemble of echo signals to produce Doppler phase shift information separated in accordance with the linearity of the echo signals.

28. The method of claim 27, wherein said step of Doppler processing includes filtering Doppler shift signals with a predetermined filter characteristic.

29. The method of claim 28, wherein said step of filtering comprises wall filtering said ultrasonic echo signals.

30. A method of separating linear and nonlinear ultrasonic signal components comprising the steps of:

transmitting a sequence of ultrasonic waves into the body which are differently amplitude or phase modulated from one wave to another;

receiving an ensemble of ultrasonic echo signals in response to said modulated ultrasonic waves, each of which contains both linear and nonlinear echo signal components; and

processing said received ensemble of echoes to produce separated nonlinear phase shift components in the presence of motion.

31. The method of claim 30, wherein said step of processing comprises Doppler processing an ensemble of echo signals from moving tissue.

32. The method of claim 30, wherein said step of processing comprises Doppler processing an ensemble of echo signals from tissue which contain second harmonic signal components.

33. The method of claim 30, wherein said step of processing comprises Doppler processing said ensemble of echo signals to produce velocity information.

34. The method of claim 30, wherein said step of processing comprises Doppler processing said ensemble of echo signals to produce power Doppler information.

35. The method of claim 30, wherein said step of processing produces a spectrum comprising separate frequency bands of odd harmonic component frequencies and even harmonic component frequencies.

36. The method of claim 30, wherein said step of receiving comprises receiving an ensemble of three or more ultrasonic echo signals.

37. An ultrasonic diagnostic imaging system which separates odd and even harmonic ultrasonic echo information comprising:

an ultrasonic wave transmitter which transmits a sequence of phase-varying ultrasonic waves into a subject;

an ultrasonic wave receiver which receives a sequence of ultrasonic echo signals in response to said phase-varying ultrasonic waves; and

a phase shift processor which processes said sequence of echo signals on the basis of relative phase characteristics to separate received echo information into odd and even harmonic signal components.

38. The ultrasonic diagnostic imaging system of claim 37, wherein said transmitter transmits a sequence of ultrasonic waves which vary in phase by 180°

from one wave to the next.

39. The ultrasonic diagnostic imaging system of claim 37, wherein said phase shift processor comprises a Doppler processor.

40. The ultrasonic diagnostic imaging system of claim 39, wherein said Doppler processor includes a Doppler shift filter.

41. The ultrasonic diagnostic imaging system of claim 37, further comprising an image processor for producing an ultrasonic image using said separated harmonic signal components.

42. The ultrasonic diagnostic imaging system of claim 37, further comprising an image processor which displays a quantified Doppler measurement using said separated harmonic signal components.

43. The ultrasonic diagnostic imaging system of claim 37, wherein said receiver receives a sequence of temporally distinct echoes from a given target location.

44. The ultrasonic diagnostic imaging system of claim 37, wherein said sequence of ultrasonic echo signals comprises a sequence of three or more echo signals.

45. An ultrasonic diagnostic imaging system which separates linear and nonlinear ultrasonic signal information comprising:

an ultrasonic wave transmitter which transmits a sequence of phase-varying ultrasonic waves into a subject;

a receiver which receives an ensemble of ultrasonic echo signals in response to said phase-varying ultrasonic waves; and

a Doppler processor which processes said ensemble of echo signals to produce Doppler phase shift information delineated in accordance with the linearity of said ultrasonic echo signals.

46. The ultrasonic diagnostic imaging system of claim 45, wherein said Doppler processor includes a Doppler shift filter.

47. The ultrasonic diagnostic imaging system of claim 46, wherein said filter comprises a wall filter.

48. The ultrasonic diagnostic imaging system of claim 45, wherein said Doppler processor processes an ensemble of echo signals from tissue.

49. The ultrasonic diagnostic imaging system of claim 45, wherein said Doppler processor processes an ensemble of echo signals from moving tissue.

50. The ultrasonic diagnostic imaging system of claim 45, wherein said Doppler processor processes an ensemble of echo signals from tissue which contain second harmonic signal components.

51. The ultrasonic diagnostic imaging system of claim 45, wherein said Doppler processor processes said ensemble of echo signals to produce velocity information.

52. The ultrasonic diagnostic imaging system of claim 45, wherein said Doppler processor processes said ensemble of echo signals to produce power Doppler information.

53. An ultrasonic diagnostic imaging system which distinguishes linear and nonlinear ultrasonic echo signal components comprising:

an ultrasonic wave transmitter which transmits a modulated sequence of ultrasonic waves into a subject;

a receiver which receives an ensemble of ultrasonic echo signals in response to said modulated transmit sequence of ultrasonic waves; and

a processor responsive to said ensemble which separates linear echo signal components including those resulting from motion and nonlinear echo signal components.

54. The ultrasonic diagnostic imaging system of claim 53, wherein said transmitter transmits ultrasonic waves which are modulated from pulse to pulse.

55. The ultrasonic diagnostic imaging system of claim 54, wherein said transmit pulse modulation introduces a phase separation between linear and nonlinear signal components.

56. The ultrasonic diagnostic imaging system of claim 54, wherein said modulation occurs at the Nyquist limit of the rate of said transmit pulses.

57. The ultrasonic diagnostic imaging system of claim 54, wherein said modulation comprises a 180°

phase variation from pulse to pulse, an amplitude modulation from pulse to pulse, or a combination of phase and amplitude modulation from pulse to pulse.

58. The ultrasonic diagnostic imaging system of claim 53, wherein said processor comprises a differential processor which differentially detects linear and nonlinear signal components.

59. The ultrasonic diagnostic imaging system of claim 53, wherein said ensemble of ultrasonic echo signals comprises an ensemble of three or more echo signals.

60. An ultrasonic diagnostic imaging system which distinguishes linear and nonlinear ultrasonic echo signal components comprising:

an ultrasonic wave transmitter which transmits a modulated sequence of ultrasonic waves into a subject;

a receiver which receives an ensemble of ultrasonic echo signals in response to said modulated transmit sequence of ultrasonic waves; and

a processor which separates phase shift information of said echoes into linear and nonlinear signal components,

wherein said processor comprises a differential processor which differentially detects linear and nonlinear signal components, and

wherein said processor comprises a power Doppler processor.

61. An ultrasonic diagnostic imaging system which distinguishes linear and nonlinear ultrasonic echo signal components comprising:

an ultrasonic wave transmitter which transmits a modulated sequence of ultrasonic waves into a subject;

a receiver which receives an ensemble of ultrasonic echo signals in response to said modulated transmit sequence of ultrasonic waves; and

a processor which separates phase shift information of said echoes into linear and nonlinear signal components,

wherein said processor comprises a differential processor which differentially detects linear and nonlinear signal components, and

wherein said processor comprises a colorflow processor.

62. An ultrasonic diagnostic imaging system which distinguishes the harmonic signal effects of moving tissue comprising:

a transmitter which transmits a sequence of phase-varying ultrasonic waves into a subject;

a receiver which receives an ensemble of echoes in response to said ultrasonic waves; and

a tissue Doppler processor which processes said ensemble to distinguish a spectrum of the odd or even harmonic signal effects of moving tissue.

63. The ultrasonic diagnostic imaging system of claim 62, wherein said transmitted waves introduce a phase shift of 180°

into Doppler signal information.

64. The ultrasonic diagnostic imaging system of claim 63, wherein said introduced phase shift translates odd harmonic signal components to a different region of said Doppler spectrum than that occupied by even harmonic signal components.

65. The ultrasonic diagnostic imaging system of claim 62, wherein said ensemble of echoes comprises an ensemble of three or more echo signals.

66. An ultrasonic diagnostic imaging system which distinguishes the harmonic signal effects of moving tissue or harmonic contrast agents comprising:

a transmitter which transmits a sequence of phase-varying ultrasonic waves into a subject;

a receiver which receives an ensemble of echoes in response to said ultrasonic waves; and

a power Doppler processor which processes said ensemble to distinguish a spectrum of the odd or even harmonic signal effects of moving tissue or of a harmonic contrast agent.

67. The ultrasonic diagnostic imaging system of claim 66, wherein said transmitter transmits a sequence of ultrasonic waves which vary in phase from one wave to the next.

68. The ultrasonic diagnostic imaging system of claim 66, wherein said transmitted waves introduce a phase shift of 180°

into Doppler signal information.

69. The ultrasonic diagnostic imaging system of claim 68, wherein said introduced phase shift translates odd harmonic signal components to a different region of said Doppler spectrum than that occupied by even harmonic signal components.

70. The ultrasonic diagnostic imaging system of claim 69, wherein each of said regions includes a range of frequencies corresponding to velocities of even or odd harmonic reflectors, including zero velocities.

71. An ultrasonic diagnostic imaging system which separates odd and even harmonic ultrasonic signal information comprising:

an ultrasonic wave transmitter which transmits a sequence of phase-varying ultrasonic waves into a subject;

a receiver which receives an ensemble of ultrasonic echo signals in response to said phase-varying ultrasonic waves; and

a Doppler processor which processes said ensemble of echo signals to produce Doppler phase shift information; and

first and second filters which pass odd harmonic Doppler phase shift information and even harmonic Doppler phase shift information, respectively.

72. The ultrasonic diagnostic imaging system of claim 71, further comprising a ratio circuit coupled to said first and second filters for computing a ratio of odd and even harmonic phase shift information.

73. The ultrasonic diagnostic imaging system of claim 72, wherein said ratio comprises the ratio of nonlinear signal information to linear signal information.

74. The ultrasonic diagnostic imaging system of claim 71, further comprising an image processor coupled to said first and second filters for producing an image containing odd and even harmonic phase shift information.

75. The ultrasonic diagnostic imaging system of claim 71, wherein said filters comprise wall filters.

76. The ultrasonic diagnostic imaging system of claim 75, wherein said filters comprise a maxtrix filter which produces two matrix results.