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Spectroscopic method and apparatus for optically detecting abnormal mammalian epithelial tissue

  • US 6,095,982 A
  • Filed: 12/11/1997
  • Issued: 08/01/2000
  • Est. Priority Date: 03/14/1995
  • Status: Expired due to Term
First Claim
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1. A method of detecting and quantifying abnormal tissue in a tissue sample, comprising:

  • providing a tissue sample;

    illuminating the tissue sample with electromagnetic radiation of a first wavelength selected to cause said tissue sample to produce a fluorescence intensity spectrum indicative of a first tissue abnormality property;

    detecting a first fluorescence intensity spectrum emitted from said tissue sample as a result of illumination with said first wavelength electromagnetic radiation;

    calculating from the first fluorescence intensity spectrum a probability of the tissue sample having the first tissue abnormality property;

    illuminating the tissue sample with electromagnetic radiation of a second wavelength selected to cause said tissue sample to produce a fluorescence intensity spectrum indicative of a second tissue abnormality property;

    detecting a second fluorescence intensity spectrum emitted from said tissue sample as a result of illumination with said second wavelength electromagnetic radiation;

    calculating from the second fluorescence intensity spectrum a probability of the tissue sample having the second tissue abnormality property; and

    quantifying the tissue sample from the first and second tissue abnormality property probability calculating steps.

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