NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method

• US 6,096,002 A
• Filed: 11/18/1998
• Issued: 08/01/2000
• Est. Priority Date: 11/18/1998
• Status: Expired due to Term

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Incorporated
• Inventors: Landau, Sergio
• Primary Examiner(s): Dawson, Glenn K.
• Assistant Examiner(s): HAYES, MICHAEL J
• Application Number:
  US09/195,334
• Time in Patent Office: 622 Days
• Field of Search: 604/68, 604/69, 604/70, 604/71, 604/131, 604/140, 604/141, 604/143
• US Class Current: 604/68
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3106 Plugs for syringes without needle
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A needle-less hypodermic jet injection device includes a hand-held injector, and a drug injection cartridge which provides a cylinder of liquid medication to be injected, an injection orifice, and an injection piston forceful movement of which in the cylinder causes an injection jet of medication to be expelled from the orifice. The injection device also includes a gas pressure capsule which powers the jet injection and which also automatically resets the injection device during an injection in order to prepare it for a subsequent injection. A multi-function component of the device is effective to place it in a safe condition allowing the device to be prepared for a next injection, and to place the device in a ready condition for allowing a jet injection to be conducted by use of the device.

Claims

1. A needle-less hypodermic jet injection device comprising:

a hand piece assembly having a body for holding a drug injection cartridge with medication cylinder, injection nozzle, and drug-injection piston;

said hand piece assembly defining a first bore within said body for movably receiving a gas-power piston, a gas power piston movably received in said bore and having a ram portion extending into said drug injection cartridge to abut with said drug-injection piston, said body and gas-power piston cooperating to define a first variable-volume chamber in said first bore;

said body also defining an elongate second bore in gas communication with said first bore and separated therefrom by a center wall portion of said body, said body carrying a sealing member circumscribing said second bore and disposed along the length thereof so as to be sealingly engageable with a cylindrical gas capsule when said capsule is received into said second bore, said gas capsule having a penetrable wall section disposed toward said center wall, and said sealing member cooperating with said gas capsule to define a second variable-volume chamber in said second bore the volume of which varies in response to movement of said gas capsule in said body relative to said center wall;

said center wall carrying a penetrator means to penetrate said penetrable wall section of said gas capsule, and said hand piece assembly carrying a discharge mechanism including a trigger outwardly disposed on said body and a hammer movable in said body in response to actuation of said trigger to forcefully move said gas capsule in said second bore so as to impale said gas capsule at said penetrable wall section thereof upon said penetrator and to communicate pressurized gas to said first chamber;

whereby, said pressurized gas in said first chamber drives said gas-power piston to effect a hypodermic jet injection from said drug injection cartridge, and pressurized gas communicated from said gas capsule into said second chamber moves said gas capsule sealingly relative to said sealing member to push back said hammer and reset said trigger.

2. The jet injection device of claim 1 wherein said body includes a cylindrical section, and said trigger is tubular and is movable axially along said cylindrical body section.

3. The jet injection device of claim 2 wherein said trigger is axially movable along said body in a direction toward said drug injection cartridge in order to effect release of said discharge mechanism, so that manual force applied to said trigger also presses said injection device against the skin of a recipient for the injection.

4. The jet injection device of claim 1 wherein said body carries a multifunction safety member manually movable rotationally between first and second positions, said trigger and multifunction safety member cooperating in a first position of said multi-function safety member to allow said trigger to move to release said discharge mechanism and actuate said hammer to effect said injection, in a second position of said multi-function safety member said member blocking movement of said trigger.

5. The injection device of claim 4 wherein said body defines a fine-dimension vent hole opening outwardly from said first chamber to ambient, so that pressurized gas is vented via said vent opening to ambient following an injection.

6. The jet injection device of claim 5 wherein said multi-function safety member in said first position thereof sealingly obstructs said vent hole to permit gas pressure in said first chamber to effect said injection.

7. The injection device of claim 6 wherein said multi-function safety member in said second position thereof overlies said vent hole and outwardly of said body defines a fine-dimension gas-dispersion gap in cooperation with said body, whereby in said second position of said safety member, pressurized gas is vented controllably from said first chamber and from said second chamber via said penetrator.

8. The injection device of claim 4 wherein said body further includes a first body section and a second body section removably securing mutually to one another to bound said second chamber, said body sections being selectively removable from one another to open said second chamber and allow removal and replacement of said gas capsule.

9. The injection device of claim 8 wherein said first and second body sections cooperatively define a latch structure securing said body sections together, and said multifunction safety member includes a feature cooperating in said second position of said safety member with said latch structure to unlatch said body sections from one another and allow said second chamber to be opened by manual removal of said body sections from one another.

10. The injection device of claim 9 wherein said first body section and said second body section each define a thread portion mutually engageable with a matching thread portion of the other of these body sections to removably secure said body sections to one another.

11. The injection device of claim 10 wherein said latch structure includes one of said first and second body sections defining a resilient tongue extending axially toward and overlying the other of these body sections, said resilient tongue distally carrying a latching key receivable into a latching keyway of the other of these body sections, and said resilient tongue including an axially extending end termination portion which is engageable by said multi-function safety member in movement of said safety member from said first position thereof toward said second position thereof to lift said resilient tongue and disengage said latching key from said latching keyway.

12. The injection device of claim 11 wherein said multi-function safety member includes a circumferentially extending camming surface engageable with said end termination portion of said tongue.

13. The injection device of claim 12 wherein said multi-function safety member is configured as a sleeve rotationally carried upon said body and rotationally movable between said first and said second positions.

14. The injection device of claim 1 wherein said discharge mechanism includes a sear for engaging and holding said hammer in a first axial position storing energy in a coil compression spring preparatory to discharge of said injector device.

15. The injection device of claim 14 wherein said discharge mechanism sear includes a groove defined on said hammer, and a ball clutch carried in said injector and circumscribing said hammer, said ball clutch having at least one ball member releasably engageable into said groove of said hammer to retain the latter in said first axial position.

16. A needle-less hypodermic jet injection device for use with a drug injection cartridge having a cylinder for receiving liquid medication, an orifice for forming the liquid into a high-velocity hypodermic injection jet, and an injection piston sealingly movable in said cylinder to displace said liquid medication via said orifice;

said needle-less injection device comprising;

an injector hand piece including an injection piston ram defining an end abutment surface for abutting with an opposing end surface of said injection piston of said drug cartridge, said injection ram piston in response to communication of pressurized gas thereto forcefully driving the injection piston to form an injection jet of liquid medication held in said cylinder of said drug cartridge;

said injection device including a body defining a pair of bores one of which sealingly and movably receives said injection ram piston, and the other of which sealingly and movably receives a pressurized gas capsule, a penetrator confronting a penetrable wall section of said pressurized gas capsule, and a hammer movable in said body to impale said pressurized gas capsule upon said penetrator, a resilient member for driving said hammer to a position impaling said pressurized gas capsule upon said penetrator, and a trigger device for releasing said hammer to be moved by said resilient member;

said body cooperating with said pressurized gas capsule to define a chamber receiving pressurized gas from said capsule, and communication of pressurized gas from said capsule to said chamber moving said pressurized gas capsule to retract said hammer to store energy in said resilient member preparatory to a next subsequent release of said hammer member.

17. A method of operating a needle-less hypodermic jet injection device using an injection cartridge having a cylinder for receiving liquid medication, an orifice for forming the liquid into a high-velocity hypodermic injection jet, and an injection piston movable sealingly in said cylinder to displace said liquid medication via said orifice;

said method including steps of;

providing said device with a body defining a bore therein into which is sealingly and movably received a pressurized gas capsule;

utilizing said body and said pressurized gas capsule to define a variable-volume chamber; and

utilizing communication of pressurized gas from said pressurized gas capsule into said variable-volume chamber to move said pressurized gas capsule in order to movably prepare said jet injection device for a next successive injection.

18. The method of operating a needle-less injection device of claim 17 further including the step of utilizing a resilient member to drive a hammer impaling said pressurized gas capsule at a penetrable wall section thereof on a penetrator carried in said body.

19. The method of operating a needle-free injection device of claim 17 further including the step of utilizing pressurized gas communicated from said pressurized gas capsule to drive a piston moving said injection piston in said cylinder to displace said liquid medication via said orifice and thus to effect said hypodermic jet injection, substantially simultaneously with movement of said gas capsule relative to said body to thereby store actuation energy in said resilient member.