Coated implantable medical device
First Claim
1. An implantable medical device (10), comprising:
- a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being composed of a base material (14);
at least one layer (18) of a first bioactive material posited on one surface of the structure (12); and
at least one porous layer (20) posited over the bioactive material layer (18), wherein said at least one porous layer (20) is composed of a polymer and said polymer provides for a controlled release of the bioactive material through said at least one porous layer.
3 Assignments
0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.
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Citations
33 Claims
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1. An implantable medical device (10), comprising:
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a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being composed of a base material (14); at least one layer (18) of a first bioactive material posited on one surface of the structure (12); and at least one porous layer (20) posited over the bioactive material layer (18), wherein said at least one porous layer (20) is composed of a polymer and said polymer provides for a controlled release of the bioactive material through said at least one porous layer. - View Dependent Claims (2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 32)
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6. An implantable medical device (10), comprising:
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a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being comprised of a base material (14); at least one layer (18) of a bioactive material posited on the at least one surface of the structure (12); at least one porous layer (20) posited over the bioactive material layer (18), wherein the at least one porous layer (20) is comprised of a polymer and said polymer provides for a controlled release of the bioactive material therethrough; and at least one additional coating layer (16) between the structure (12) and the at least one bioactive material layer (18); wherein the at least one additional coating layer (16) is less porous than, but comprised of the same polymer as, the at least one porous layer (20). - View Dependent Claims (7)
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25. An implantable medical device, comprising:
a structure adapted for introduction into a patient, the structure having at least one surface and being comprised of a base material;
wherein the base material comprises apertures within a surface of the base material and containing at least one bioactive material within said apertures;
wherein at least one porous layer is posited over said base material and said at least one bioactive material contained within said apertures; and
wherein said at least one porous layer is comprised of a polymer and said polymer provides for a controlled release of the at least one bioactive material.- View Dependent Claims (26, 27, 28, 29, 33)
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30. An implantable medical device comprising:
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a structure adapted for introduction into a patient, the structure having at least one surface and being comprised of a base material;
wherein the base material comprises apertures within a surface of the base material and having at least one bioactive material within said apertures;
wherein at least one porous layer is posited over said base material and said at least one bioactive material is contained within said apertures; and
wherein said at least one porous, layer is comprised of a polymer and said polymer provides for a controlled release of said at least one bioactive material;wherein said apertures are selected from the group consisting of holes, slots, grooves or wells and may have a sectional shape of a half circle, a letter V or a truncated square; and wherein the base material comprises a substantially non-porous coating, and said at least one porous layer overlies the holes, grooves, slots or wells containing said at least one bioactive material. - View Dependent Claims (31)
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Specification