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Electrostatic enzyme biosensor

  • US 6,096,497 A
  • Filed: 07/07/1998
  • Issued: 08/01/2000
  • Est. Priority Date: 06/15/1998
  • Status: Expired due to Fees
First Claim
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1. A biosensor for detecting the presence and/or concentration of an analyte based on the physical change in position of immobilized enzyme molecules in the presence of said analyte, comprising:

  • (i) a multilayer sensor comprising a conducting or semiconducting layer and an optional self-assembled monolayer or other chemical entity directly or indirectly bound to this layer;

    (ii) enzyme molecules bound to or coordinated with the conducting or semiconducting layer of the multilayer substrate either through their interaction with the self-assembled monolayer/chemical entity or their interaction with the conducting or semiconducting support itself; and

    (iii) a means for measuring directly or indirectly electrostatic effects that result from motions of the immobilized enzyme molecules during their contact with analyte.

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