Bonding bio-active materials to expanded polytetrafluoroethylene or polyethylene terephthalate via an isocyanate-terminated spacer
First Claim
1. A method of preparing a bio-active coating comprising:
- a) providing a hydrophobic, bio-compatible polymeric substrate selected from the group consisting of expanded polytetrafluoroethylene and polyethylene terephthalate;
b) providing reactive OH or NH2 functionality on a surface of said substrate, said reactive functionality being bonded to said substrate through a reactive carbon atom therein;
c) reacting said reactive OH or NH2 reactive functionality of said bio-compatible polymeric substrate with a hydrophilic spacer having at least one reactive isocyanate functional group at its first and second ends by reacting said at least one reactive isocyanate functional group at said first end of said spacer with said reactive OH or NH2 functionality on said bio-compatible polymeric substrate to bond said spacer thereto; and
d) reacting said at least one reactive isocyanate functional group at said second end of said spacer with a bio-active agent to bond said bio-reactive agent to said spacer.
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Accused Products
Abstract
A bio-active material such as heparin, urokinase or streptokinase is bonded via a hydrophilic spacer to a functionality on the surface of a hydrophobic, bio-compatible polymeric substrate to provide a coating of the bio-active material on the surface. The substrate surface is preferably the surface of an implantable medical device such as a vascular graft. An amine and/or hydroxyl functionality on the substrate surface is reacted with an isocyanate group at an end of the hydrophilic spacer to bond the spacer to the substrate, and the bio-active material is reacted with an isocyanate group at another end of the spacer to bond the bio-active material to the spacer. Polymeric substrates include expanded polytetrafluoroethylene and polyethylene terephthalate, and the hydroxyl and/or amine functionality may be provided on the substrate surface by plasma glow discharge. A preferred spacer is an isocyanate end-blocked poly(ethylene oxide). Reaction of the functionality of the substrate with the isocyanate group of the spacer may be catalyzed with dibutyltindilaurate, and reaction of the bio-active material with the isocyanate group of the spacer may be catalyzed with 1-(3 -dimethylaminopropyl)-3-ethylcarbodiimide.
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Citations
9 Claims
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1. A method of preparing a bio-active coating comprising:
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a) providing a hydrophobic, bio-compatible polymeric substrate selected from the group consisting of expanded polytetrafluoroethylene and polyethylene terephthalate; b) providing reactive OH or NH2 functionality on a surface of said substrate, said reactive functionality being bonded to said substrate through a reactive carbon atom therein; c) reacting said reactive OH or NH2 reactive functionality of said bio-compatible polymeric substrate with a hydrophilic spacer having at least one reactive isocyanate functional group at its first and second ends by reacting said at least one reactive isocyanate functional group at said first end of said spacer with said reactive OH or NH2 functionality on said bio-compatible polymeric substrate to bond said spacer thereto; and d) reacting said at least one reactive isocyanate functional group at said second end of said spacer with a bio-active agent to bond said bio-reactive agent to said spacer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification