Multi-slide assembly including slide, frame and strip cap, and methods thereof
First Claim
1. A strip cap for use in sealing an opening in at least one reaction vessel having an internal wall defining the opening, the strip cap including:
- (a) a cap member having an external wall, a mating portion of which is configured to abut the internal wall of the reaction vessel around a perimeter of the opening; and
(b) a sealing ring circumscribing the external wall of the cap member, the sealing ring configured to form a compression seal with the internal wall of the reaction vessel.
3 Assignments
0 Petitions
Accused Products
Abstract
A multi-slide assembly includes various components that alone or in combination facilitate testing of test samples with minimal manipulation of assay components. Moreover, the various device components permit centrifugation, culturing and analysis of each test sample to be performed in the same assembly. A frame retains a plurality of reaction vessel assemblies between a pair of opposing channels that are configured to slidably receive the opposing ends of each reaction vessel assembly. A strip cap seals the openings in each reaction vessel using cap members having sealing rings circumscribing the external walls thereof to form compression seals with internal walls of the reaction vessels. Furthermore, in a method of making a multi-well slide assembly, an ultrasonic welding process removably bonds a plurality of wells to a slide plate to provide an adequate seal therebetween during centrifugation, yet still enable separation thereof by an operator.
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Citations
49 Claims
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1. A strip cap for use in sealing an opening in at least one reaction vessel having an internal wall defining the opening, the strip cap including:
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(a) a cap member having an external wall, a mating portion of which is configured to abut the internal wall of the reaction vessel around a perimeter of the opening; and (b) a sealing ring circumscribing the external wall of the cap member, the sealing ring configured to form a compression seal with the internal wall of the reaction vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A multi-well slide assembly, comprising:
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(a) a slide plate; (b) a plurality of wells coupled to the slide plate, each well including an internal wall defining an opening to the well; and (c) a strip cap, including; (1) a strip member; (2) a plurality of cap members coupled to the strip member, each cap member having an external wall, a mating portion of which is configured to abut the internal wall of one of the plurality of wells around a perimeter of the opening thereto; and (3) a plurality of sealing rings, each sealing ring circumscribing the external wall of one of the plurality of cap members, and each sealing ring configured to form a compression seal with the internal wall of one of the plurality of wells. - View Dependent Claims (15, 16, 17)
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18. A frame for use in retaining a plurality of reaction vessels, each reaction vessel of the type including opposing ends, the frame comprising;
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(a) a pair of opposing channels facing in different directions from one another, the pair of opposing channels including first and second ends and configured to slidably receive the opposing ends of each reaction vessel; and (b) first and second retaining mechanisms respectively disposed proximate the first and second ends of the pair of opposing channels and configured to retain each reaction vessel within the pair of opposing channels. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. An assembly, comprising:
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(a) a plurality of reaction vessels, each including opposing ends; and (b) a frame retaining the plurality of reaction vessels, the frame including; (1) a pair of opposing channels including first and second ends and configured to slidably receive the opposing ends of the plurality of reaction vessels; and (2) first and second retaining mechanisms respectively disposed proximate the first and second ends of the pair of opposing channels and configured to retain each reaction vessel within the pair of opposing channels. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46)
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47. A reaction vessel, comprising:
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(a) a slide plate; (b) a sidewall member including a sidewall including an end and having a thickness, and an energy director including a base coupled to an end of the sidewall and having a width; and (c) an ultrasonically-welded and controllably-weakened bond removably securing the sidewall member to the slide plate, the bond comprising a fused junction between the slide plate and the sidewall member and formed of substantially the entire energy director, wherein the slide plate and sidewall member form a mating surface having a width between the width of the energy director and the thickness of the sidewall. - View Dependent Claims (48, 49)
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Specification