Apparatus and method for noninvasive glucose measurement

• US 6,097,975 A
• Filed: 05/13/1998
• Issued: 08/01/2000
• Est. Priority Date: 05/13/1998
• Status: Expired due to Fees

• Current Assignee: Olga Spivak, Paul Spivak
• Original Assignee: BioSensors, Inc.
• Inventors: Pankevich, Miroslav Orestes, Slavina, Lubov Aleksandrovna, Izvarina, Natalia Leonidovna, Petrovsky, Gury Timofeevich, Slavin, Michail Davidovich
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/076,795
• Time in Patent Office: 811 Days
• Field of Search: 600/310, 600/316, 600/322, 600/473, 600/476, 600/326, 356/39
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

An apparatus and method for noninvasively measuring blood glucose concentration. The apparatus disclosed uses light pulses directed onto a patient'"'"'s skin and reflected back from the patient to measure blood glucose. Reflected light is passed through light filters that transmit a narrow bandwidth of light within a range of wavelengths that is absorbed by glucose and then measured. Unreflected light is passed through identical light filters and also measured. The two measurements are then compared and used to calculate the patient'"'"'s blood glucose concentration.

Claims

1. An apparatus for noninvasively measuring the glucose concentration in the blood of a patient, comprising;

(a) a light source,

(b) a test channel comprising (i) a first light filter capable of transmitting a narrow bandwidth of light within a range of wavelengths that is absorbed by glucose, (ii) a first photodetector capable of measuring the light passing the light filter, (iii) a first pulse amplifier, and (iv) a first analog-to-digital converter,

(c) a first optic unit comprising optical fibers and capable of transporting light pulses from the light source to the skin of a patient, receiving light reflected back from the patient, and transporting the reflected light to the test channel,

(d) a reference channel comprising (i) a second light filter, (ii) a second photodetector, (iii) a second pulse amplifier, and (iv) a second analog-to-digital converter, each identical to the corresponding elements in the test channel,

(e) a second optic unit capable of transporting light pulses from the light source to the reference channel, and

(f) a processing unit capable of comparing the output of the test channel to the output of the reference channel to quantify the intensity of light absorbed by the glucose in the blood of the patient.

2. The apparatus of claim 1, wherein the first and second light filters are capable of transmitting light having a bandwidth of about 20 nm or less.

3. The apparatus of claim 2, wherein the first and second light filters are capable of transmitting light within a range of wavelengths of between about 2080 nm to 2200 nm.

4. The apparatus of claim 3, wherein the optical fibers comprise pure silica glass core fibers or doped silica glass core fibers.

5. An apparatus for noninvasively measuring the glucose concentration in the blood of a patient, comprising:

(a) a light source,

(b) a light filter capable of transmitting a narrow bandwidth of light within a range of wavelengths that is absorbed by glucose,

(c) a first optic unit comprising optical fibers and capable of transporting light pulses from the light source to the skin of a patient, receiving light reflected back from the patient, and transporting the reflected light to the light filter,

(d) a second optic unit capable of transporting light pulses directly from the light source to the light filter,

(e) a photodetector capable of measuring the light passing the light filter,

(f) a processing unit capable of comparing the intensity of the reflected light passing through the light filter to the intensity of the light directly from the light source to quantify the intensity of light absorbed by the glucose in the blood of the patient.

6. The apparatus of claim 5, wherein the light filter is capable of transmitting light having a bandwidth of about 20 nm or less.

7. The apparatus of claim 6, wherein the light filter is capable of transmitting light within a range of wavelengths of between about 2080 nm to 2200 nm.

8. The apparatus of claim 5, wherein the optical fibers comprise pure silica glass core fibers or doped silica glass core fibers.

9. A method for noninvasively measuring the glucose concentration in the blood of a patient, comprising:

(a) projecting a pulse of light through a fiber optic device placed in direct contact with the patient'"'"'s skin,

(b) measuring the intensity of light reflected from the patient over a narrow bandwidth within a range of wavelengths that is absorbed by glucose,

(c) measuring the intensity of light projected onto the patient'"'"'s skin over the same bandwidth and wavelengths used in step (b), and

(d) comparing the measurements of light obtained in steps (b) and (c) to quantify the intensity of light absorbed by the glucose in the blood of the patient.

10. The method of claim 9, wherein the bandwidth of light measured in steps (b) and (c) is about 20 nm or less.

11. The method of claim 10, wherein the reflected light measured in steps (b) and (c) is within a range of wavelengths of between about 2080 nm to 2200 nm.

12. The method of claim 9, wherein the light projected onto the patient'"'"'s skin has a narrow bandwidth and is within a range of wavelengths that is absorbed by glucose.

13. The method of claim 9, wherein the light projected onto the patient'"'"'s skin has a bandwidth of about 20 nm or less.

14. The method of claim 13, wherein the light projected onto the patient'"'"'s skin is within a range of wavelengths of between about 2080 nm and 2200 nm.

15. The method of claim 14, wherein the light projected onto the patient'"'"'s is emitted from a laser diode.

16. The method of claim 9, wherein the light projected through the fiber optic device is not wavelength or intensity modulated.

17. A method for noninvasively measuring the glucose concentration in the blood of a patient, comprising:

(a) generating a pulse of light,

(b) projecting a first portion of the pulse of light through a fiber optic device placed in direct contact with the patient'"'"'s skin,

(c) passing the light reflected from the patient through a first light filter that transmits a narrow bandwidth of light within a range of wavelengths that is absorbed by glucose,

(d) passing a second portion of the pulse of light through a second light filter identical to first light filter,

(e) measuring the intensity of the light passing through the first and second light filters, and

(f) comparing the intensity of light passing through the first light filter to the intensity of light passing through the second light filter to quantify the intensity of light absorbed by the glucose in the blood of the patient.

18. The method of claim 17, wherein the first and second light filters transmit light having a bandwidth of about 20 nm or less.

19. The method of claim 18, wherein the first and second light filters transmit light within a range of wavelengths of between about 2080 nm to 2200 nm.

20. The method of claim 19, wherein the fiber optic device is placed on the lateral side of the patient'"'"'s ear lobe and a reflective device is placed on the medial side of the patient'"'"'s ear lobe.