Quantitative electroencephalographic (QEEG) process and apparatus for assessing attention deficit hyperactivity disorder

• US 6,097,980 A
• Filed: 12/24/1998
• Issued: 08/01/2000
• Est. Priority Date: 12/24/1998
• Status: Expired due to Term

• Current Assignee: Joel F. Lubar, Vincent J. Monastra
• Original Assignee: Joel F. Lubar, Vincent J. Monastra
• Inventors: Lubar, Joel F., Monastra, Vincent J.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): CARTER, RYAN CHRISTOPHER
• Application Number:
  US09/220,719
• Time in Patent Office: 586 Days
• Field of Search: 600/544
• US Class Current: 600/544
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A simplified, quantitative electroencephalographic (QEEG) technique and apparatus for testing and assessing individuals for Attention Deficit Hyperactivity Disorder (ADHD) is described. The simplified procedure and apparatus is consistent with emerging neuroanatomical models of the etiology of ADHD, makes the testing affordable to the public, and allows for practitioners to conduct the testing on an outpatient basis within their offices. The process comprises a new scanning method that obtains quantitative EEG data from an electrode placed at a single, active cranial site (Cz, the vertex). Multiple short periods (90 seconds) of digitized EEG are obtained. The electrophysiological power in two frequency bands (theta: 4-8 Hz; beta: 13-21 Hz) is examined. A computer that is programmed with the capacity to conduct a Fast Fourier Transformation selects and statistically analyzes the power in these specific EEG frequency bands. A baseline neurometric index is obtained by calculating the ratio of the electrophysiological power recorded within the theta band by that recorded in the beta band while the individual maintains an eyes open, fixed gaze. Thereafter, the individual being tested for ADHD is evaluated under conditions requiring attentive behavior (reading, listening, drawing). A theta/beta power ratio is calculated for each of these tasks. Finally, an average of the power ratios across the baseline, reading, listening and drawing tasks is calculated and an Attentional Index is obtained and compared to a database obtained through the evaluations of a normative sample of individuals not having ADHD or any other neurological disorder. The assessment of the presence and severity of ADHD is determined from this comparison.

Claims

1. A quantitative electroencephalographic technique for testing and assessing individuals for Attention Deficit Hyperactivity Disorder (ADHD), comprising the steps of:

a) placing an electrode at a single cranial site of an individual to be tested for ADHD;

b) obtaining digitized EEG data in two frequency bands;

theta (4-8 Hz) and beta (13-21 Hz);

c) obtaining a baseline neurometric index comprising a ratio of the electrophysiological power recorded in the theta band divided by the electrophysiological power recorded in the beta band obtained in step (b);

d) thereafter, testing said individual in accordance with steps (b) and (c) under conditions requiring attentive behavior;

e) obtaining an overall Attentional Index for said individual which represents the average theta/beta power ratio calculated during said baseline and said attentive behavior tasks; and

f) comparing said Attentional Index obtained in step (e) to a normative database of individuals without ADHD to determine presence and severity of said individual'"'"'s ADHD.

2. The quantitative technique for testing and assessing individuals for ADHD in accordance with claim 1, wherein said behavioral testing in step (d) comprises testing said individual during a reading task.

3. The quantitative technique for testing and assessing individuals for ADHD in accordance with claim 1, wherein said behavioral testing in step (d) comprises testing said individual during a listening task.

4. The quantitative technique for testing and assessing individuals for ADHD in accordance with claim 1, wherein said behavioral testing in step (d) comprises testing said individual during a drawing task.

5. The quantitative technique for testing and assessing individuals for ADHD in accordance with claim 1, further comprising the step of:

g) utilizing a fast Fourier analysis to transform said data obtained in step (b).

6. The quantitative technique for testing and assessing individuals for ADHD in accordance with claim 1, wherein said baseline neurometric index is obtained while said individual gazes fixedly at a point.

7. The quantitative technique for testing and assessing individuals for ADHD in accordance with claim 1, further comprising the step of:

g) placing at least one reference ear electrode on said individual.

8. Apparatus for quantitative testing and assessing individuals for Attention Deficit Hyperactivity Disorder (ADHD), comprising:

a monitor for displaying EEG data;

an EEG device operatively connected to said monitor and to an individual under evaluation for ADHD, said EEG device providing signals representative of the cortical electrophysiological activity of said individual;

a processor disposed between said monitor and said EEG device, said processor being programmed to process said signals and to provide a neurometric Attentional Index for said individual; and

storage means operatively connected to said processor for providing a comparison between a normative database and the said Attentional Index for said individual, to determine the presence and to quantify the severity of ADHD thereof.

9. The apparatus for quantitative testing and assessing individuals for ADHD in accordance with claim 8, further comprising an analog-to-digital converter disposed between said processor and said EEG device.

10. The apparatus for quantitative testing and assessing individuals for ADHD in accordance with claim 8, further comprising a digital processing card disposed between said processor and said EEG machine.

11. The apparatus for quantitative testing and assessing individuals for ADHD in accordance with claim 8, wherein said individual is connected to said EEG device at a single active cranial site.

12. The apparatus for quantitative testing and assessing individuals for ADHD in accordance with claim 11, wherein said single, active cranial site comprises the Cz site, the vertex.

13. The apparatus for quantitative testing and assessing individuals for ADHD in accordance with claim 11, wherein said individual is connected to said EEG device at at least one ear lob for obtaining a reference signal.