Radioisotope stent with non-radioactive end sections

• US 6,099,455 A
• Filed: 11/25/1998
• Issued: 08/08/2000
• Est. Priority Date: 11/25/1998
• Status: Expired due to Fees

• Current Assignee: Isostent, Inc. (Cardinal Health, Inc.)
• Original Assignee: Isostent, Inc. (Cardinal Health, Inc.)
• Inventors: Columbo, Antonio, Fischell, Robert E.
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): MCPHERSON, CATHERINE E
• Application Number:
  US09/198,966
• Time in Patent Office: 622 Days
• Field of Search: 600/1-8, 606/78, 606/108, 606/191, 606/194, 606/195, 606/198
• US Class Current: 600/3
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy

Abstract

A radioisotope stent that is made radioactive for most of the stent'"'"'s length at a center section of the stent, but is not radioactive for a limited length at each end section of the stent. Such a stent design would have a negligible radiation level at the extreme ends of the stent. Therefore, there will not be any portion of the dilated stenosis that has no mechanical support from the stent and is also exposed to a moderate level of radiation. Furthermore, all portions of the dilated stenosis that are exposed to a high or moderate level of radiation will be mechanically supported by the stent so as to preclude the phenomena of late vascular contraction. Thus it is an object of this invention to have a stent that is designed with a comparatively high level of radioactivity at a longitudinally central section of the stent and would be free of any radioactivity at each of the two end sections of the stent.

Claims

1. A stent having a thin-walled, cylindrical structure for implantation at the site of a vascular stenosis, the stent having a proximal end section that extends longitudinally for a length L2, a distal end section that extends longitudinally for a length L3, and a central section extending longitudinally for a length L1, the central section being situated longitudinally between the proximal end section and the distal end section, the central section of the stent being radioactive and both the proximal end section and the distal end section being non-radioactive.

2. The stent of claim 1 wherein the length of the proximal end section is approximately equal to the length of the distal end section.

3. The stent of claim 1 wherein the central section is made radioactive by the inclusion of a beta particle emitting radioisotope.

4. The stent of claim 3 wherein the beta particle emitting radioisotope is phosphorous-32.

5. The stent of claim 4 wherein the length of either end section is between 2 and 5 mm.

6. The stent of claim 4 wherein the phosphorous-32 has a radioactivity level between 1.0 and 50 microCuries.

7. The stent of claim 3 wherein the beta particle emitting radioisotope is yttrium-90.

8. The stent of claim 7 wherein the length of either end section is between 3 and 6 mm.

9. The stent of claim 7 wherein the yttrium-90 has a radioactivity level between 2.0 and 100 microCuries.

10. The stent of claim 1 wherein the central section of the stent is made radioactive by the inclusion of a radioisotope that is predominately a gamma ray emitter.

11. The stent of claim 1 wherein the central section of the stent is made radioactive by the inclusion of a radioisotope that is predominantly an x-ray emitter.

12. The stent of claim 1 wherein the stent has a distal end and a proximal end and a longitudinal center that is situated centrally between the distal end and the proximal end, and at the stent'"'"'s outer surface, the level of radioactivity at the distal and proximal ends of the stent is between 1% and 30% of the level of radioactivity at the longitudinal center of the stent.

13. The stent of claim 1 wherein the length of the central section is between 20 and 90 percent of the total length of the stent.

14. The stent of claim 1 wherein the length of either end section is between 5 and 40 percent of the total length of the stent.

15. The stent of claim 1 wherein the stent is a balloon expandable stent.

16. The stent of claim 1 wherein the stent is a self-expandable stent.