Drug coating with topcoat
First Claim
1. A medical device having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens.
2 Assignments
0 Petitions
Accused Products
Abstract
A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.
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Citations
27 Claims
- 1. A medical device having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens.
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18. A method of using an implantable stent prosthesis comprising:
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(a) providing an implantable stent prosthesis having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens; (b) implanting the device into the body of a patient; and (c) allowing the biologically active material to be released such that the topcoat limits the burst release of the biologically active material. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification