Stomach submucosa derived tissue graft
First Claim
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1. A composition capable of inducing the formation of endogenous tissue when implanted at a site in need of endogenous tissue growth comprising stomach submucosa delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
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Abstract
A tissue graft composition comprising stomach submucosal tissue delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate is described. The graft composition can be or implanted into a host to replace or support damaged or diseased tissues.
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Citations
13 Claims
- 1. A composition capable of inducing the formation of endogenous tissue when implanted at a site in need of endogenous tissue growth comprising stomach submucosa delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
- 8. The use of stomach submucosa for the preparation of a tissue graft construct useful for inducing endogenous tissue growth when implanted in warm-blooded vertebrates, said stomach submucosa being delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
- 11. A method for inducing the formation of endogenous tissue at a site in need of endogenous tissue growth in a warm blooded vertebrate, said method comprising contacting said site with a graft composition comprising stomach submucosa in an amount effective to induce endogenous tissue growth at the site the composition is administered.
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