Controlled release oral tablet having a unitary core
DC CAFCFirst Claim
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1. A controlled release pharmaceutical tablet comprising:
- (a) a core comprising;
(i) 50-98% of an antihyperglycemic drug;
(ii) 0-40% of a binding agent;
(iii) 0-20% of an absorption enhancer; and
(b) a semipermeable membrane coating covering said core wherein the membrane is permeable to the passage of water and biological fluids and is impermeable to the passage of the antihyperglycemic drug wherein said coating comprises 50-99% of a polymer;
0-40% of a flux enhancer and 0-25% of a plasticizer; and
(c) at least one passageway in the semipermeable membrane for the release of the antihyperglycemic drug.
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Abstract
A controlled release antihyperglycemic tablet that does not contain an expanding polymer and comprising a core containing the antihyperglycemic drug, a semipermeable membrane coating the core and at least one passageway in the membrane.
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Citations
29 Claims
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1. A controlled release pharmaceutical tablet comprising:
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(a) a core comprising; (i) 50-98% of an antihyperglycemic drug; (ii) 0-40% of a binding agent; (iii) 0-20% of an absorption enhancer; and (b) a semipermeable membrane coating covering said core wherein the membrane is permeable to the passage of water and biological fluids and is impermeable to the passage of the antihyperglycemic drug wherein said coating comprises 50-99% of a polymer;
0-40% of a flux enhancer and 0-25% of a plasticizer; and(c) at least one passageway in the semipermeable membrane for the release of the antihyperglycemic drug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A controlled release antihyperglycemic tablet comprising:
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(a) a core consisting essentially of; (i) metformin or a pharmaceutically acceptable salt thereof; (ii) a water soluble binding agent; and (iii) an absorption enhancer; and (b) a semipermeable membrane coating covering said core comprising; (i) cellulose acetate; (ii) a flux enhancer; and (iii) a plasticizer; and (c) at least one passageway in the semipermeable membrane. - View Dependent Claims (28)
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29. A controlled release pharmaceutical tablet consisting essentially of:
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(a) a core comprising; (i) 75-95% of an antihyperglycemic drug; (ii) 3-15% of a binding agent; and (iii) 2-15% of an absorption enhancer; and (b) a semipermeable membrane coating covering said core wherein the semipermeable membrane is permeable to the passage of water and biological fluids and is impermeable to the passage of the antihyperglycemic drug and comprises; (i) 75-95% of a polymer; (ii) 2-20% of a flux enhancer; (iii) 2-15% of a plasticizer; and (c) at least one passageway in the semipermeable membrane for the release of the antihyperglycemic drug.
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Specification