Cassette for measuring parameters of blood

• US 6,101,406 A
• Filed: 02/26/1998
• Issued: 08/08/2000
• Est. Priority Date: 02/27/1997
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Inventors: Holder, Ronald G., Gehrich, John L., Hacker, Thomas G.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/031,415
• Time in Patent Office: 894 Days
• Field of Search: 600/310, 600/322, 356/39, 356/244, 356/246, 422/44, 422/68.1, 422/55, 422/102, 422/104, 436/63, 436/66, 436/68, 436/172
• US Class Current: 600/322
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/362261 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362262 Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362263 Details of incorporated filters
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10

Abstract

A cassette useful for measuring one or more parameters of blood in, for example, a cardiopulmonary bypass circuit has a convex coupling for releasable connection with a mating, concave coupling of a measuring device. The coupling of the cassette includes flexible leg portions that can be moved toward each other under the influence of finger pressure to detach the cassette from the measuring device. Optionally, the cassette includes a body carrying one or more sensors, and also includes a casing that can be detached from the body when desired. A shunt circuit arrangement enables the cassette to be connected to the bypass circuit either before or during a surgical procedure.

Claims

1. A system for measuring one or more parameters of blood comprising:

a casing having walls defining a chamber for receiving a quantity of blood;

at least one sensor connected to said casing adjacent said chamber for sensing at least one parameter of the blood in said chamber;

a measuring device including a housing, at least one light source connected to the housing and at least one light detector connected to the housing; and

a connector for releasably coupling said casing to said housing, said connector including a first coupling connected to said casing and a second coupling connected to said housing, said first coupling having a convex configuration and said second coupling having a concave configuration.

2. The system of claim 1 wherein said first coupling and said second coupling have matching, generally U-shaped configurations.

3. The system of claim 1 wherein said first coupling includes at least one flexible leg portion with an outwardly extending tab, and wherein said second coupling includes at least one groove for receiving said tab.

4. The system of claim 1 wherein said first coupling has a generally U-shaped configuration with a central section and two leg portions that extend away from said central section, said leg portions each including at least one outer surface, said at least one outer surface of one of said leg portions and said at least one outer surface of the other of said leg portions extending in respective reference planes that are oriented at an angle in the range of about 28 degrees to about 32 degrees relative to each other.

5. The system of claim 4 wherein each of said leg portions includes an outwardly extending tab.

6. The system of claim 4 wherein said central section includes a recess and a generally oval-shaped rim surrounding said recess, and wherein said at least one sensor is located in said recess.

7. The system of claim 4 wherein said leg portions are movable toward each other under the influence of finger pressure.

8. The system of claim 7 wherein said leg portions each include at least one outwardly extending tab.

9. The system of claim 1 wherein said first coupling includes a central section having a recess and a generally oval-shaped rim surrounding said recess, and wherein said at least one sensor is located in said recess.

10. The system of claim 1 wherein said at least one sensor includes at least two sensors, wherein said first coupling includes a rim surrounding said at least two sensors, and wherein said first coupling includes an alignment key connected to said rim and extending between an adjacent pair of said at least two sensors.

11. The system of claim 1 wherein said at least one sensor includes a potassium sensor.

12. A cassette for measuring one or more parameters of blood comprising:

a casing having walls defining a chamber for receiving a quantity of blood;

at least one sensor connected to said casing adjacent said chamber for sensing at least one parameter of the blood in said chamber; and

a coupling for connecting said casing to a blood parameter measurement device, said coupling having a convex configuration with a central section, wherein said at least one sensor is located in said central section, and wherein said coupling includes at least one flexible leg portion with a tab for releasable connection to the blood parameter measurement device, said at least one leg portion extending in a direction away from said central section, said tab extending outwardly in a lateral direction from said at least one leg portion.

13. The cassette of claim 12 wherein said at least one leg portion includes two flexible leg portions that extend away from said central section, said two leg portions each including at least one outer surface, said at least one outer surface of one of said two leg portions and said at least one outer surface of the other of said two leg portions extending in respective reference planes that are oriented at an angle in the range of about 28 degrees to about 32 degrees relative to each other.

14. The cassette of claim 13 wherein each of said two leg portions includes an outwardly extending tab.

15. The cassette of claim 13 wherein said central section includes a recess and a generally oval-shaped rim surrounding said recess, and wherein said at least one sensor is located in said recess.

16. The cassette of claim 13 wherein said two leg portions are movable toward each other under the influence of finger pressure.

17. The cassette of claim 16 wherein said two leg portions are integrally connected to said central section.

18. The cassette of claim 12 wherein said at least one sensor includes at least two sensors, wherein said coupling includes a rim surrounding said at least two sensors, and wherein said coupling includes an alignment key connected to said rim and extending between an adjacent pair of said at least two sensors.

19. The cassette of claim 12 wherein said at least one sensor includes a potassium sensor.

20. The cassette of claim 12 wherein said chamber has a longitudinal axis and includes an inlet portion, an outlet portion and a middle portion between said inlet portion and said outlet portion, wherein said inlet portion and said outlet portion each have a generally circular configuration in reference planes perpendicular to said longitudinal axis, wherein said middle portion has a non-circular configuration in reference planes perpendicular to said longitudinal axis, said circular configurations of said inlet portion and said outlet portion each having respective areas that are each approximately equal to the area of said non-circular configuration of said middle portion.

21. The cassette of claim 12 wherein said coupling is releasably connected to said casing.

22. The cassette of claim 12 wherein said coupling is integrally connected to said casing.

23. A cassette for measuring one or more parameters of blood comprising:

a casing having walls defining a chamber for receiving a quantity of blood;

at least one sensor connected to said casing adjacent said chamber for sensing at least one parameter of the blood in said chamber; and

a coupling for connecting said casing to a blood parameter measurement device, said coupling having a convex configuration and having two outer surfaces extending in respective reference planes that are oriented at an angle in the range of about 28 degrees to about 32 degrees relative to each other.

24. The cassette of claim 23, wherein said reference planes are oriented at an angle of about 30 degrees relative to each other.

25. The cassette of claim 23, wherein said coupling includes two leg portions and at least one tab connected to at least one of said leg portions.

26. The cassette of claim 25, wherein said leg portions each have an outer end region, and wherein said at least one tab includes a pair of tabs extending away from each other, each of said tabs being coupled to a respective one of said outer end regions.

27. The cassette of claim 23, wherein said coupling includes a central section having a recess and a generally oval-shaped rim surrounding said recess, and wherein said at least one sensor is located in said recess.

28. The cassette of claim 23, wherein said at least one sensor includes at least two sensors, wherein said coupling includes a rim surrounding said at least two sensors, and wherein said coupling includes an alignment key connected to said rim and extending between an adjacent pair of said at least two sensors.

29. The cassette of claim 23, wherein said chamber has a longitudinal axis and includes an inlet portion, an outlet portion and a middle portion between said inlet portion and said outlet portion, wherein said inlet portion and said outlet portion each have a generally circular configuration in reference planes perpendicular to said longitudinal axis, wherein said middle portion has a non-circular configuration in reference planes perpendicular to said longitudinal axis, said circular configurations of said outlet portions having respective areas that are each approximately equal to the area of said non-circular configuration of said middle portion.

30. The cassette of claim 23, wherein said coupling is releasably connected to said casing.

31. The cassette of claim 23, wherein said coupling is integrally connected to said casing.

32. The cassette of claim 23, wherein said coupling includes two leg portions that are flexible for movement toward each other under the influence of finger pressure.

33. The cassette of claim 32, wherein said leg portions each include at least one outwardly extending tab.

34. The cassette of claim 23, wherein said at least one sensor includes a potassium sensor.

35. A cassette for measuring one or more parameters of blood comprising:

a casing having walls defining a chamber for receiving a quantity of blood;

at least one sensor connected to said casing adjacent said chamber for sensing at least one parameter of the blood in said chamber; and

a coupling having a convex configuration for connecting said casing to a blood parameter measurement device,

wherein said chamber has a longitudinal axis and includes an inlet portion, an outlet portion and a middle portion between said inlet portion and said outlet portion, wherein said inlet portion and said outlet portion each have a generally circular configuration in reference planes perpendicular to said longitudinal axis, wherein said middle portion has a non-circular configuration in reference planes perpendicular to said longitudinal axis, said circular configurations of said inlet portion and said outlet portion having respective areas that are each approximately equal to the area of said non-circular configuration of said middle portion.

36. The cassette of claim 35, wherein said non-circular configuration is an oval.

37. A cassette adapted for releasable coupling to a blood parameter measuring device for measuring one or more parameters of blood, said cassette comprising:

a body;

at least one sensor connected to said body for sensing at least one parameter of the blood;

a casing having walls sections at least partially defining a chamber, an inlet for admitting blood to said chamber and an outlet for discharging blood from said chamber; and

a connector for detachably coupling said body to said casing in such a manner that said at least one sensor is located next to said chamber for sampling one or more parameter of blood flowing through said chamber.

38. The cassette of claim 37, wherein said cassette includes a pair of leg portions connected to said body, and wherein said connector detachably couples said casing to said body at a location between said leg portions.

39. The cassette of claim 38, wherein said casing is elongated and has an external rib extending along its length.

40. The cassette of claim 38, wherein said leg portions each include at least one opening, and wherein said casing includes a pair of wings each having at least one protruding ear that is received in a respective one of said at least one openings when said casing is coupled to said body.

41. The cassette of claim 40, wherein said wings are flexible and movable toward each other under the influence of finger pressure.

42. The cassette of claim 38, including a membrane secured to said casing for communicating blood in said chamber with said at least one sensor.

43. The cassette of claim 42, wherein said casing has a side opening, wherein said membrane extends across said side opening, and wherein said casing includes a pair of flexible wings extending away from said chamber in a direction away from said side opening.

44. The cassette of claim 43, wherein said at least one sensor includes at least two sensors arranged along a reference axis, and wherein said side opening has a longitudinal axis that is parallel with said reference axis when said casing is connected to said body.

45. The cassette of claim 37, wherein said body includes a coupling having a convex configuration for connection to a blood parameter measuring device.

46. The cassette of claim 45, wherein said coupling includes at least one flexible leg portion with a tab for releasable connection to a blood parameter measurement device, said at least one leg portion extending in a direction away from said central section, said tab extending outwardly in a lateral direction from said at least one leg portion.

47. The cassette of claim 46, wherein said coupling includes a central section and wherein said at least one leg portion includes two flexible leg portions that extend away from said central section, said two leg portions each including at least one outer surface, said at least one outer surface of one of said two leg portions and said at least one outer surface of the other of said two leg portions extending in respective reference planes that are oriented at an angle in the range of about 28 degrees to about 32 degrees relative to each other.

48. The cassette of claim 47, wherein each of said two leg portions includes an outwardly extending tab.

49. The cassette of claim 37, wherein said coupling includes two outer surfaces extending in respective reference planes that are oriented at an angle in the range of about 28 degrees to about 32 degrees relative to each other.

50. The cassette of claim 37, wherein said body includes a central section with a recess and a generally oval-shaped rim surrounding said recess, and wherein said at least one sensor is located in said recess.

51. The cassette of claim 37, wherein said at least one sensor includes at least two sensors, wherein said coupling includes a rim surrounding said at least two sensors, and wherein said coupling includes an alignment key connected to said rim and extending between an adjacent pair of said at least two sensors.

52. The cassette of claim 37, wherein said at least one sensor includes a potassium sensor.

53. The cassette of claim 37, wherein said chamber has a longitudinal axis and includes an inlet portion, an outlet portion and a middle portion between said inlet portion and said outlet portion, wherein said inlet portion and said outlet portion each have a generally circular configuration in reference planes perpendicular to said longitudinal axis, wherein said middle portion has a non-circular configuration in reference planes perpendicular to said longitudinal axis, said circular configurations of said inlet portion and said outlet portion each having respective areas that are each approximately equal to the area of said non-circular configuration of said middle portion.

54. A cassette adapted for releasable coupling to a blood parameter measuring device for measuring one or more parameters of blood, said cassette comprising:

a body;

at least one sensor connected to said body for sensing at least one parameter of the blood; and

a casing detachably coupled to said body, said casing having walls defining an elongated chamber for receiving a quantity of blood, said casing also having an external rib extending along its length at a location remote from said body.

55. The cassette of claim 54, wherein said cassette includes two leg portions with outer surfaces that extend in respective reference planes that are oriented at an angle in the range of about 28 degrees to about 32 degrees relative to each other.

56. The cassette of claim 55, wherein said body includes an oval-shaped recess and wherein said at least one sensor is located in said recess.

57. The cassette of claim 55, wherein each of said two leg portions includes at least one outwardly extending tab.

58. The cassette of claim 57, wherein said at least one sensor includes at least two sensors, wherein said body includes a rim surrounding said at least two sensors, and wherein said body includes an alignment key connected to said rim and extending between an adjacent pair of said at least two sensors.

59. The cassette of claim 54, wherein said at least one sensor includes a potassium sensor.

60. The cassette of claim 54 wherein said body includes a coupling having a convex configuration for connection to a blood parameter measuring device.

61. The cassette of claim 54 wherein said casing includes a side opening, and wherein said cassette includes a membrane extending across said side opening.

62. A cassette for measuring one or more parameters of blood comprising:

a casing having walls defining a chamber for receiving a quantity of blood;

at least one sensor connected to said casing adjacent said chamber for sensing at least one parameter of blood in said chamber; and

a coupling for connecting said casing to a blood parameter measurement device, said coupling including a generally oval-shaped recess and wherein said at least one sensor is located in said recess.

63. The cassette of claim 62 wherein said at least one sensor includes at least two sensors and wherein said coupling includes an alignment key extending between an adjacent pair of sensors.

64. The cassette of claim 62 wherein said at least one sensor includes at least two sensors, wherein said coupling includes a rim surrounding said at least two sensors, and wherein said coupling includes an alignment key connected to said rim and extending between an adjacent pair of said at least two sensors.

65. The cassette of claim 62 wherein said at least one sensor includes a potassium sensor.

66. The cassette of claim 62 wherein said coupling is releasably connected to said casing.

67. The cassette of claim 62 wherein said coupling is integrally connected to said casing.