Probe and method to obtain accurate area measurements from cervical lesions
First Claim
1. A method of determining an area or length of a three-dimensional feature on a compliant body part from a two-dimensional image thereof, comprising the steps of:
- (a) providing an imaging system for producing two-dimensional image coordinate data including intensity values at each pixel, respectively, of a two-dimensional image of the body part;
(b) providing a transparent rigid body having a first major surface and an icon having a predetermined geometrical shape and lying in a plane having a predetermined relationship to the first major surface, the icon being on one of the first major surface and another surface having a predetermined relationship to the first major surface;
(c) pressing the first major surface of the rigid body against a portion of the body part including the feature so as to flatten the feature to the first major surface;
(d) operating the imaging system to produce a two-dimensional image of the feature and the icon;
(e) determining a slant angle of the first major surface by measuring lengths of at least two axes in the two-dimensional image of the icon and computing a ratio between the axes, and measuring an area or length in the two-dimensional image of the feature outlined by a pointing device; and
(f) correcting the area or length in the two-dimensional image of the feature in accordance with the slant angle of the body part at that pixel to obtain a corrected three-dimensional area or length.
1 Assignment
0 Petitions
Accused Products
Abstract
The area of a three-dimensional lesion on a cervix is determined from a two-dimensional image of the cervix. A transparent area fixation probe is used to flatten the lesion just prior to photography. The image is analyzed using a personal computer and dedicated imaging software program that calculates the cosine of the slant angle of the planar defining platform of the area fixation probe. This is accomplished by determining the apparent minor to major axis ratio of a standardization circular icon present on the planar defining platform. The lesion itself is outlined by using a mouse pointing device and the number of pixels within the outlined region are counted. The inverse of the cosine of the slant angle is then used as a correction factor to obtain the true area of the lesion by multiplying the number of pixels within the region by the correction factor.
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Citations
13 Claims
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1. A method of determining an area or length of a three-dimensional feature on a compliant body part from a two-dimensional image thereof, comprising the steps of:
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(a) providing an imaging system for producing two-dimensional image coordinate data including intensity values at each pixel, respectively, of a two-dimensional image of the body part; (b) providing a transparent rigid body having a first major surface and an icon having a predetermined geometrical shape and lying in a plane having a predetermined relationship to the first major surface, the icon being on one of the first major surface and another surface having a predetermined relationship to the first major surface; (c) pressing the first major surface of the rigid body against a portion of the body part including the feature so as to flatten the feature to the first major surface; (d) operating the imaging system to produce a two-dimensional image of the feature and the icon; (e) determining a slant angle of the first major surface by measuring lengths of at least two axes in the two-dimensional image of the icon and computing a ratio between the axes, and measuring an area or length in the two-dimensional image of the feature outlined by a pointing device; and (f) correcting the area or length in the two-dimensional image of the feature in accordance with the slant angle of the body part at that pixel to obtain a corrected three-dimensional area or length. - View Dependent Claims (2, 3, 4, 5)
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6. A method of determining an area or length of a three-dimensional feature on a compliant object from a two-dimensional image thereof, comprising the steps of:
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(a) providing an imaging system for producing two-dimensional image coordinate data including intensity values at each pixel, respectively, of a two-dimensional image of the object; (b) providing a transparent rigid body having a first major surface and an icon having a predetermined geometrical shape and lying in a plane having a predetermined relationship to the first major surface, the icon being on one of the first major surface and another surface having a predetermined relationship to the first major surface; (c) pressing the first major surface of the rigid body against a portion of the object including the feature so as to flatten the feature to the first major surface; (d) operating the imaging system to produce a two-dimensional image of the feature and the icon; (e) determining a slant angle of the first major surface by measuring lengths of at least two axes in the two-dimensional image of the icon and computing a ratio between the axes, and measuring an area or length in the two-dimensional image of the feature outlined by a pointing device; and (f) correcting the area or length in the two-dimensional image of the feature in accordance with the slant angle of the object at that pixel to obtain a corrected three-dimensional area or length.
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7. A system for determining an area or length of a three-dimensional feature on a compliant body part from a two-dimensional image thereof, comprising:
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(a) a processor-based imaging system for producing two-dimensional image coordinate data including intensity values at each pixel, respectively, of a two-dimensional image of the body part; (b) a transparent rigid body having a first major surface and an icon having a predetermined geometrical shape and lying in a plane parallel to the first major surface; (c) a member connected to apply a force on the rigid body to press a first major surface of the rigid body against a portion of the body part including the feature so as to flatten the feature against the first major surface, the imaging system operating to produce a two-dimensional image of the feature and the icon; and (e) a stored program in a processor of the imaging system operating to i. determine a slant angle of the first major surface relative to an optical axis of the imaging system by measuring lengths of at least two axes in the two-dimensional image of the icon and computing a ratio of the lengths of the axes, ii. measure an area or length of the two-dimensional image of the feature outlined by a pointing device, and iii. correct the area or length of the two-dimensional image of the feature in accordance with the slant angle of the body part to obtain a corrected three-dimensional area or length. - View Dependent Claims (8)
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9. A method of determining an area or length of a three-dimensional feature on a compliant body part from a two-dimensional image thereof, comprising the steps of:
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(a) providing an imaging system for producing two-dimensional image coordinate data including intensity values at each pixel, respectively, of a two-dimensional image of the body part; (b) providing a transparent rigid body having a first major surface and a force-transmitting member having a first end portion coupled to the rigid body, and providing a predetermined first angle between an axis of the force-transmitting member and the first major surface; (c) pressing the first major surface of the rigid body against a portion of the body part including the feature so as to flatten the feature to the first major surface, and maintaining a predetermined second angle between the axis of the force-transmitting member and an optical axis of the imaging system; (d) operating the imaging system to produce a two-dimensional image of the feature and the icon and measuring an area or length in the two-dimensional image of the feature outlined by a pointing device; (e) determining a slant angle of the first major surface from the first and second angles; and (f) correcting the area or length in the two-dimensional image of the feature in accordance with the slant angle of the body part at that pixel to obtain a corrected three-dimensional area or length. - View Dependent Claims (10, 11, 12)
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13. A method of determining a change in size of an area or length of a three-dimensional feature on a compliant body part of a subject from a two-dimensional image thereof, comprising the steps of:
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(a) providing an imaging system for producing two-dimensional image coordinate data including intensity values at each pixel, respectively, of a two-dimensional image of the body part; (b) providing a transparent rigid body having a first major surface and an icon having a predetermined geometrical shape and lying in a plane having a predetermined relationship to the first major surface, the icon being on one of the first major surface and another surface having a predetermined relationship to the first major surface; (c) pressing the first major surface of the rigid body against a portion of the body part including the feature so as to flatten the feature to the first major surface; (d) operating the imaging system to produce a two-dimensional image of the feature and the icon; (e) determining a slant angle of the first major surface by measuring lengths of at least two axes in the two-dimensional image of the icon and computing a relationship between the lengths of the axes, and measuring an area or length in the two-dimensional image of the feature outlined by a pointing device; (f) correcting the area or length in the two-dimensional image of the feature in accordance with the slant angle of the body part at that pixel to obtain a corrected three-dimensional area or length; (g) storing the two-dimensional image and the slant angle as baseline information for the subject; and (h) repeating steps (c) through (f) for the same feature at a later time and comparing a resulting updated corrected three-dimensional area or length of the feature to baseline corrected three-dimensional area or length of the feature.
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Specification