System and method for atrial autocapture in single-chamber pacemaker modes using far-field detection

• US 6,101,416 A
• Filed: 07/29/1998
• Issued: 08/08/2000
• Est. Priority Date: 07/29/1998
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Sloman, Laurence S.
• Primary Examiner(s): Schaetzle, Kennedy J.
• Application Number:
  US09/124,811
• Time in Patent Office: 741 Days
• Field of Search: 607/28, 607/9, 607/27, 607/62, 600/509, 600/521
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/3714 Atrial capture

Abstract

An implantable pacemaker automatically verifies atrial capture and performs atrial stimulation energy assessment when atrial capture is absent. The pacemaker delivers a stimulation pulse in the atrial chamber of the heart and samples the resulting far-field signal from the ventricular chamber during a predetermined far-field interval window. The pacemaker then compares the far-field signal sample to a predetermined far-field signal recognition template. If the far-field signal sample is approximately equal to the far-field signal recognition template, then atrial capture is deemed verified; otherwise, the pacemaker performs an atrial stimulation energy determination. Optionally, the pacemaker automatically determines the timing of the far-field interval window and defines the far-field signal recognition template.

Claims

1. A system for detecting capture in an atrial chamber of a patient'"'"'s heart and implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the system comprising:

pulse generating means for generating a stimulation pulse for delivery to the atrial chamber through the lead to trigger a subsequent contraction in a ventricular chamber of the heart so as to produce a far-field signal;

first sampling means for generating a far-field signal sample by sampling the produced far-field signal during a far-field interval window;

window generating means for periodically determining the far-field interval window; and

first control means for comparing the far-field signal sample to a predetermined far-field signal recognition template, such that;

(i) when the far-field signal sample is approximately equal to the predetermined far-field signal recognition template, the first control means generates a first signal indicative of presence of atrial capture, and

(ii) when the far-field signal sample is not approximately equal to the predetermined far-field signal recognition template, the first control means generates a second signal indicative of absence of atrial capture.

2. The system of claim 1, further comprising sensing means, connected to the lead and to the first sampling means, for sensing the produced far-field signal through the lead.

3. The system of claim 1, wherein the far-field interval window is sized so as to be of sufficient duration to accommodate sampling of the produced far-field signal when the subsequent ventricular contraction occurs within a predetermined period after the stimulation pulse is generated.

4. The system of claim 3, wherein the window generating means for periodically determining the far-field interval window comprises:

testing means for determining an approximate AV conduction time value by performing an atrioventricular conduction test in the heart;

first memory means for storing the determined approximate conduction time value; and

second control means for;

(i) repeatedly and sequentially triggering the testing means and the first memory means to generate and store by the first memory means a predetermined plurality of the AV conduction time values;

(ii) determining an average AV conduction time value by averaging the plural AV conduction time values; and

(iii) defining a time interval defining the far-field interval window having a predetermined duration and positioning the far-field interval window so that the time interval is substantially centered at a time delay measured from the generation of the stimulation pulse, the delay being approximately equal to the average AV conduction time value.

5. The system of claim 4, further comprising template generating means for generating the predetermined far-field signal recognition template, the template generating means comprising:

third control means for causing the pulse generating means to generate a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(i) produce a response signal in the atrial chamber, and

(ii) produce the far-field signal caused by the subsequently triggered contraction in the ventricular chamber of the heart;

second sampling means for;

(i) generating a response sample by sampling the response signal; and

(ii) generating a far-field signal sample by sampling the far-field signal after a time delay following the generation of the stimulation pulse, the delay being substantially equal to the predetermined AV conduction time value;

second memory means for storing the response sample and far-field signal sample; and

fourth control means for;

(i) repeatedly and sequentially triggering the third control means, the second sampling means, and the second memory means to generate and store by the second memory means a predetermined plurality of the response samples and a predetermined plurality of the far-field signal samples;

(ii) determining an average response by averaging the plural response samples;

(iii) determining an average far-field signal by averaging the plural far-field signal samples; and

(iv) determining the far-field signal recognition template by comparing the average response from the average far-field signal.

6. The system of claim 1, further comprising:

pacing energy determination means responsive to the first control means for determining, when the first control means generates the second signal, an atrial pacing energy in the atrial chamber.

7. A system for determining a far-field signal recognition template for use in identification of a far-field signal originating from a ventricle of a patient'"'"'s heart, the system being implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the system comprising:

pulse generating means for generating a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(i) produce a response signal in the atrial chamber, and

(ii) produce a far-field signal caused by a subsequently triggered contraction in a ventricular chamber of the heart;

sampling means for;

(i) generating a response sample by sampling the produced response signal; and

(ii) generating a far-field signal sample by sampling the produced far-field signal after a delay following the generation of the stimulation pulse, the delay being substantially equal to a predefined AV conduction time value;

memory means for storing the produced response and far-field signal samples; and

control means for;

(i) repeatedly and sequentially triggering the pulse generating means, the sampling means, and the memory means to generate and store by the memory means a predetermined plurality of the response samples and a predetermined plurality of the far-field signal samples;

(ii) determining an average response by averaging the plural response samples;

(iii) determining an average far-field signal by averaging the plural far-field signal samples; and

(iv) determining a far-field signal recognition template by comparing the average response from the average far-field signal.

8. The system of claim 7, further comprising sensing means, connected to the lead and to the first sampling means, for sensing the produced far-field signal through the lead.

9. A system for detecting capture in an atrial chamber of a patient'"'"'s heart and implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the system comprising:

a pulse generator that generates a stimulation pulse for delivery to the atrial chamber through the lead to trigger a subsequent contraction in a ventricular chamber of the heart so as to produce a far-field signal;

a signal sampler operatively connected to the pulse generator, that generates a far-field signal sample by sampling the produced far-field signal during a far-field interval window;

a window generator for periodically determining the far-field interval window; and

a controller operatively connected to the pulse generator and the signal sampler that compares the far-field signal sample to a predetermined far-field signal recognition template, such that;

(i) when the far-field signal sample is approximately equal to the predetermined far-field signal recognition template, the controller generates a first signal indicative of presence of atrial capture, and

(ii) when the far-field signal sample is not approximately equal to the predetermined far-field signal recognition template, the controller generates a second signal indicative of absence of atrial capture.

10. The system of claim 9, further comprising a sensor, operatively connected to the lead and to the first signal sampler, that senses the produced far-field signal through the lead.

11. The system of claim 9, wherein the far-field interval window is sized so as to be of sufficient duration to accommodate sampling of the produced far-field signal when the subsequent ventricular contraction occurs within a predetermined period after the stimulation pulse is generated.

12. The system of claim 9, further comprising stimulation energy determination circuitry operatively connected to the controller that determines, when the controller generates the second signal, an atrial stimulation energy in the atrial chamber.

13. The system of claim 9 wherein the window generator comprises testing circuitry that determines an approximate AV conduction time value by performing an atrioventricular conduction test in the heart and a memory that stores the determined approximate conduction time value, and wherein the window generator is operable to cause the controller to:

(i) repeatedly and sequentially trigger the testing circuitry and the memory to generate and store in the memory a predetermined plurality of the AV conduction time values;

(ii) determine an average AV conduction time value by averaging the plural AV conduction time values; and

(iii) define a time interval defining the far-field interval window having a predetermined duration and positioning the far-field interval window so that the time interval is substantially centered at a time delay measured from the generation of the stimulation pulse, the delay being approximately equal to the average AV conduction time value.

14. (Amended) The system of claim 9, further comprising a template generator that generates the predetermined far-field signal recognition template, the template generator comprising:

a memory; and

pulse trigger circuitry operable to cause the pulse generator to generate a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(i) produce a response signal in the atrial chamber, and

(ii) produce a far-field signal caused by the subsequently triggered contraction in the ventricular chamber of the heart;

sampling trigger circuitry operable to cause the signal sampler to;

(i) generate a response sample by sampling the response signal; and

(ii) generate a far-field signal sample by sampling the far-field signal after a time delay following the generation of the stimulation pulse, the delay being substantially equal to a predetermined AV conduction time value; and

wherein

the template generator is operable to cause the controller to;

(i) repeatedly and sequentially trigger the pulse trigger circuitry, the sampling trigger circuitry and the memory, to generate and store in the memory a predetermined plurality of the response samples and a predetermined plurality of the far-field signal samples;

(ii) determine an average response by averaging the plural response samples;

(iii) determine an average far-field signal by averaging the plural far-field signal samples; and

(iv) determine the far-field signal recognition template by comparing the average response from the average far-field signal.

15. A system for determining a far-field signal recognition template for use in identification of a far-field signal originating from a ventricle of a patient'"'"'s heart, the system being implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the system comprising:

a pulse generator that generates a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(i) produce a response signal in the atrial chamber, and

(ii) produce a far-field signal caused by a subsequently triggered contraction in a ventricular chamber of the heart;

a signal sampler that;

(i) generates a response sample by sampling the produced response signal; and

(ii) generates a far-field signal sample by sampling the produced far-field signal after a delay following the generation of the stimulation pulse, the delay being substantially equal to a predefined AV conduction time value;

a memory that stores the response and far-field signal samples; and

a controller that;

(i) repeatedly and sequentially triggers the pulse generator, the signal sampler, and the memory to generate and store in the memory a predetermined plurality of the response samples and a predetermined plurality of the far-field signal samples;

(ii) determines an average response by averaging the plural response samples;

(iii) determines an average far-field signal by averaging the plural far-field signal samples; and

(iv) determines the far-field signal recognition template by comparing the average response from the average far-field signal.

16. The system of claim 15, further comprising a sensor, connected to the lead and to the signal sampler, for sensing the produced far-field signal through the lead.

17. A method for detecting capture in an atrial chamber of a patient'"'"'s heart and implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the method comprising the steps of:

(a) generating, by a pulse generator, a stimulation pulse for delivery to the atrial chamber through the lead to trigger a subsequent contraction in a ventricular chamber of the heart so as to produce a far-field signal;

(b) generating, by a signal sampler, a far-field signal sample by sampling the produced far-field signal during a far-field interval window, wherein the far-field interval window is periodically determined; and

(c) comparing, by a controller, the far-field signal sample to a predetermined far-field signal recognition template, and

(1) when the far-field signal sample is approximately equal to the predetermined far-field signal recognition template, generating a first signal indicative of presence of atrial capture, and

(2) when the far-field signal sample is not approximately equal to the predetermined far-field signal recognition template, generating a second signal indicative of absence of atrial capture.

18. The method of claim 17, further comprising a step following step (a) of sensing the produced far-field signal by a sensor and through the lead.

19. The method of claim 17, wherein the far-field interval window is sized so as to be of sufficient duration to accommodate sampling of the produced far-field signal when the subsequent ventricular contraction occurs within a predetermined period after step (a).

20. The method of claim 17, further comprising the step of, when the second signal is generated at step (c), determining, by stimulation energy determination circuitry, an atrial stimulation energy.

21. The method of claim 17, further comprising the steps of:

(d) determining, by the controller, an approximate AV conduction time value by performing an atrioventricular conduction test in the heart;

(e) storing, in a memory, the determined approximate conduction time value;

(f) generating a predetermined plurality of stored AV conduction time values by repeating, by the controller, steps (d) through (e) for a predetermined number of repetitions;

(g) determining, by the controller, an average AV conduction time value by averaging the plural AV conduction time values; and

(h) determining, by the controller, a time interval defining the far-field interval window having a duration and positioning the far-field interval window so that the time interval is substantially centered at a time delay measured from the generation of the stimulation pulse at step (a), the delay being approximately equal to the average AV conduction time value.

22. The method of claim 17, further comprising the steps of:

(i) generating, by the pulse generator prior to step (a), a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(1) produce a response signal in the atrial chamber, and

(2) produce the far-field signal caused by the subsequently triggered contraction in the ventricular chamber of the heart;

(j) generating, by the signal sampler, a response sample by sampling the produced response signal;

(k) generating, by the signal sampler, a far-field signal sample by sampling the produced far_-- field signal after a delay following step (a), the delay being substantially equal to a predetermined AV conduction time value;

(l) storing, in a memory, the response and far-field signal samples;

(m) generating, a predetermined plurality of the stored response samples and a predetermined plurality of the stored far-field signal samples by repeating, by the controller, steps (i) through (l) for a predetermined number of repetitions;

(n) determining, by the controller, an average response by averaging the plural response samples;

(o) determining, by the controller, an average far-field signal by averaging the plural far-field signal samples; and

(p) determining, by the controller, the far-field signal recognition template by subtracting the average response from the average far-field signal.

23. A method for determining a far-field signal recognition template for use in identification of a far-field signal originating from a ventricle of a patient'"'"'s heart, the method being implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the method comprising the steps of:

(a) generating, by a pulse generator, a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(1) produce a response signal in the atrial chamber, and

(2) produce a far-field signal caused by a subsequently triggered contraction in a ventricular chamber of the heart;

(b) generating, by a signal sampler, a response sample by sampling the produced response signal;

(c) generating, by the signal sampler, a far-field signal sample by sampling the produced far-field signal after a delay following step (a), the delay being substantially equal to a predetermined AV conduction time value;

(d) storing, in a memory, the response and far-field signal samples;

(e) generating, a predetermined plurality of the stored response samples and a predetermined plurality of the stored far-field signal samples by repeating, by a controller, steps (a) through (d) for a predetermined number of repetitions;

(f) determining, by the controller, an average response by averaging the plural response samples;

(g) determining, by the controller, an average far-field signal by averaging the plural far-field signal samples; and

(h) determining, by the controller, the far-field signal recognition template by subtracting the average response from the average far-field signal.

24. The method of claim 23, further comprising a step of sensing after step (a), by a sensor and through the lead, the produced far-field signal.

25. A system for detecting capture in an atrial chamber of a patient'"'"'s heart and implemented in an implantable pacemaker implanted in the patient and connected to the atrial chamber via a lead, the system comprising:

a pulse generator that generates a stimulation pulse for delivery to the atrial chamber through the lead to trigger a subsequent contraction in a ventricular chamber of the heart so as to produce a far-field signal;

a signal sampler operatively connected to the pulse generator, that generates a far-field signal sample by sampling the produced far-field signal during a predetermined far-field interval window;

a template generator for periodically determining a far-field signal recognition template; and

a controller operatively connected to the pulse generator and the signal sampler that compares the far-field signal sample to the far-field signal recognition template, such that;

(i) when the far-field signal sample is approximately equal to the far-field signal recognition template, the controller generates a first signal indicative of presence of atrial capture, and

(ii) when the far-field signal sample is not approximately equal to the far-field signal recognition template, the controller generates a second signal indicative of absence of atrial capture.

26. The system of claim 25 further comprising a sensor, operatively connected to the lead and to the first signal sampler, that senses the produced far-field signal through the lead.

27. The system of claim 25 wherein the predetermined far-field interval window is sized so as to be of sufficient duration to accommodate sampling of the produced far-field signal when the subsequent ventricular contraction occurs within a predetermined period after the stimulation pulse is generated.

28. The system of claim 25 further comprising stimulation energy determination circuitry operatively connected to the controller that determines, when the controller generates the second signal, an atrial stimulation energy in the atrial chamber.

29. The system of claim 25 further comprising a window generator that generates the predetermined far-field window, the window generator comprising testing circuitry that determines an approximate AV conduction time value by performing an atrioventricular conduction test in the heart and a memory that stores the determined approximate conduction time value, wherein the window generator is operable to cause the controller to:

(i) repeatedly and sequentially trigger the testing circuitry and the memory to generate and store in the memory a predetermined plurality of the AV conduction time values;

(ii) determine an average AV conduction time value by averaging the plural AV conduction time values; and

(iii) define a time interval defining the far-field interval window having a predetermined duration and positioning the far-field interval window so that the time interval is substantially centered at a time delay measured from the generation of the stimulation pulse, the delay being approximately equal to the average AV conduction time value.

30. The system of claim 25 wherein the template generator comprises:

pulse trigger circuitry operable to cause the pulse generator to generate a stimulation pulse for delivery to the atrial chamber through the lead so as to;

(i) produce a response signal in the atrial chamber, and

(ii) produce a far-field signal caused by the subsequently triggered contraction in the ventricular chamber of the heart;

sampling trigger circuitry operable to cause the signal sampler to;

(i) generate a response sample by sampling the response signal; and

(ii) generate a far-field signal sample by sampling the far-field signal after a time delay following the generation of the stimulation pulse, the delay being substantially equal to a predetermined AV conduction time value; and

wherein

the template generator is operable to cause the controller to;

(i) repeatedly and sequentially trigger the pulse trigger circuitry, the sampling trigger circuitry, and the memory to generate and store in the memory a predetermined plurality of the response samples and a predetermined plurality of the far-field signal samples;

(ii) determine an average response by averaging the plural response samples;

(iii) determine an average far-field signal by averaging the plural far-field signal samples; and

(iv) determine the far-field signal recognition template by comparing the average response from the average far-field signal.