Disposable injector device

• US 6,102,896 A
• Filed: 09/08/1999
• Issued: 08/15/2000
• Est. Priority Date: 09/08/1999
• Status: Expired due to Fees

• Current Assignee: Nova Bio-Pharma Technologies Limited
• Original Assignee: Cambridge Biostability Limited (Nova Bio-Pharma Holdings Ltd.)
• Inventors: Roser, Bruce Joseph
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US09/392,293
• Time in Patent Office: 342 Days
• Field of Search: 604/218, 604/110, 604/201-205, 604/207, 604/210, 604/232, 604/187, 604/136, 604/137, 604/123, 604/124
• US Class Current: 604/218
• CPC Class Codes: A61M 2005/31508 provided on the piston-rod
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61M 5/2429 by telescoping of ampoules or carpules with the syringe body
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/422 Desensitising skin
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion
• CPC Class Codes: A61M 5/482 Varying injection pressure, e.g. by varying speed of injection

Abstract

The present invention is a single use injector device for injecting parenteral medications which operates by hand force. The injector device has a plunger section and a base. As hand force is applied to a moving portion of the plunger section, break tabs or a snap ring resist its motion toward the patient'"'"'s skin surface. The break tabs or snap ring release abruptly as the hand force reaches a snap point. The motion of the moving portion then drives the medication through the skin surface and into the body of the patient. If the medication is in liquid form, the actual injection may be carried out through a hollow needle attached to the plunger section. Alternatively, the suddenly increased pressure of the medication at the snap point may be used to form a liquid jet for needleless injection. Part or all of the medication may be contained in a glass needle which dissolves in the body after injection. The injector device requires little training to use, reduces perceived pain, and improves injection safety.

Claims

1. A single use injector device for injecting at least one parenteral medication into the body of a patient through a skin surface, the injector device operating by hand force, the injector device comprising:

a plunger section including a plunger, the plunger having a longitudinal axis, a first end, and a second end;

a base, the base being generally tubular and having a plunger end and a nozzle end, the base having a cavity and an outer surface, the cavity having a nozzle end and a longitudinal axis, the longitudinal axis of the cavity being coincident with the longitudinal axis of the plunger, the plunger being located at least partially within the cavity, the plunger sliding within the cavity parallel to the longitudinal axis of the cavity;

snap means for resisting movement of at least a moving portion of the plunger section from an initial position toward the skin surface as the hand force is applied to the moving portion of the plunger section, the snap means releasing the moving portion of the plunger section abruptly as a snap point is reached, the moving portion of the plunger section moving rapidly toward the skin surface after the snap point is reached, the snap means not including a spring; and

injection means for injecting the medication, the motion of the moving portion of the plunger section toward the skin surface after the snap point is reached driving the parenteral medication through the skin surface and into the body of the patient.

2. The injector device according to claim 1, wherein:

at least a part of the parenteral medication is a liquid medication;

the plunger section includes a barrel, the barrel is tubular and has a first end and a second end, the first end is at least partially closed, the barrel has a reservoir adapted to contain the liquid medication, the barrel has a longitudinal axis coincident with the longitudinal axis of the plunger, the barrel has an inner surface and an outer surface, the barrel is located at least partially within the cavity, and the barrel slides within the cavity parallel to the longitudinal axis of the cavity;

the first end of the plunger is located within the barrel and is adapted to contact the liquid medication, the first end has a periphery, the periphery of the first end of the plunger forms a sliding seal with the inner surface of the barrel, the seal is liquid-tight, and the plunger slides with respect to the barrel parallel to the longitudinal axis of the plunger; and

the motion of the moving portion of the plunger section toward the skin surface expels the liquid medication from the reservoir and injects the liquid medication into the body of the patient.

3. The injector device according to claim 2, wherein the moving portion of the plunger section includes the plunger and the barrel.

4. The injector device according to claim 3, wherein the first end of the barrel is located between the first end of the plunger and the nozzle end of the cavity.

5. The injector device according to claim 3, wherein the plunger is located between the first end of the barrel and the nozzle end of the cavity.

6. The injector device according to claim 1, wherein the moving portion of the plunger section includes the plunger, the first end of the plunger is located within the cavity, the cavity has a cavity surface, the first end of the plunger has a periphery, and the periphery of the first end of the plunger contacts the cavity surface.

7. The injector device according to claim 1, wherein the base includes a bore extending between the nozzle end of the cavity and the nozzle end of the base.

8. The injector device according to claim 7, wherein:

at least a part of the parenteral medication is a liquid medication, further comprising;

reservoir means for containing the liquid medication; and

wherein;

the injection means includes a hollow needle, the hollow needle is tubular and has an attachment end and a free end, the attachment end is attached to the plunger section, the free end is sharp, the interior of the hollow needle is in fluid communication with the reservoir means, the free end of the hollow needle is located within the bore when the plunger section is in the initial position, and the motion of the moving portion of the plunger section after the snap point is reached drives the free end of the hollow needle through the skin surface, so that the liquid medication is expelled from the reservoir means through the hollow needle into the body of the patient.

9. The injector device according to claim 7, wherein:

the plunger section includes a shaft, the shaft has an attachment end and a free end, the shaft extends parallel to the longitudinal axis of the plunger and toward the skin surface, the free end of the shaft is blunt, and the free end of the shaft is located within the bore when the plunger section is in the initial position; and

the injection means includes a glass needle, the glass needle is adapted to contain at least a part of the parenteral medication, the glass needle is located within the bore and between the shaft and the nozzle end of the base when the plunger section is in the initial position, and the motion of the moving portion of the plunger section after the snap point is reached drives the shaft toward the skin surface through the bore, the free end of the shaft striking the glass needle and driving the glass needle through the skin surface, so that the glass needle remains in the body of the patient and dissolves in the body of the patient.

10. The injector device according to claim 9, wherein the shaft is solid.

11. The injector device according to claim 9, wherein the shaft is tubular.

12. The injector device according to claim 11, wherein:

a part of the parenteral medication is a liquid medication;

further comprising;

reservoir means for containing the liquid medication; and

wherein;

the interior of the shaft is in fluid communication with the reservoir means, and the motion of the moving portion of the plunger section after the snap point is reached drives the free end of the shaft through the skin surface after the glass needle, so that the liquid medication is expelled from the reservoir means through the shaft and into the body of the patient after the glass needle.

13. The injector device according to claim 12, wherein:

the liquid medication is contained in the cavity; and

the shaft includes at least one perforation near the attachment end of the shaft, the interior of the shaft is in fluid communication with the cavity through the perforation.

14. The injector device according to claim 7, wherein:

at least a part of the parenteral medication is a liquid medication;

further comprising;

reservoir means for containing a part of the liquid medication; and

wherein;

at least a part of the liquid medication is contained in the bore, and the bore is in fluid communication with the reservoir means; and

the injection means includes jet injection means for injecting the liquid medication in the form of a liquid jet, the motion of the moving portion of the plunger section after the snap point is reached increases the pressure of the liquid medication within the reservoir means and the bore to form the liquid jet, and the liquid medication is expelled from the reservoir means through the bore and into the body of the patient.

15. The injector device according to claim 14, wherein:

the plunger section includes a shaft, the shaft has an attachment end and a free end, the shaft extends parallel to the longitudinal axis of the plunger and toward the skin surface, the shaft is tubular and has a free end, the free end of the shaft is located within the bore when the plunger section is in the initial position;

the bore has a nozzle end, the nozzle end of the bore includes a sealing membrane, and the bore includes a seal surrounding the shaft, the seal being liquid-tight; and

the nozzle end of the base includes a tapered nozzle.

16. The injector device according to claim 1, wherein the hand force is applied to the second end of the plunger.

17. The injector device according to claim 1, wherein the plunger section includes a cap, the cap has a central section and a peripheral section, the central section is generally planar and has a periphery, the peripheral section is attached to the periphery of the central section and extends approximately perpendicular to the central section and toward the skin surface, each of the central and peripheral sections has an outer surface and an inner surface, the hand force is applied to the central section of the cap, the inner surface of the peripheral section of the cap contacts the outer surface of the base, and the moving portion of the plunger section includes the cap.

18. The injector device according to claim 17, wherein the central section of the cap is flat.

19. The injector device according to claim 17, wherein the second end of the plunger is integrally attached to the central section of the cap.

20. The injector device according to claim 17, wherein the cap and the plunger are not integrally attached, the inner surface of the cap is near the second end of the plunger, the motion of the moving portion of the plunger section toward the skin surface after the snap point is reached brings the inner surface of the cap into contact with the second end of the plunger, and the contact of the inner surface of the cap and the second end of the plunger drives the plunger toward the skin surface.

21. The injector device according to claim 20, wherein the central section of the cap has a retaining projection extending from the inner surface of the central section, the retaining projection is tubular and has an inner surface, and the second end of the plunger is adjacent to the inner surface of the retaining projection after the snap point is reached.

22. The injector device according to claim 17, wherein:

at least a part of the parenteral medication is a liquid medication;

the plunger section includes a barrel, the barrel is tubular and has a first end and a second end, the first end is at least partially closed, the barrel has a reservoir adapted to contain the liquid medication, the barrel has a longitudinal axis parallel to the longitudinal axis of the plunger, the barrel has an inner surface and an outer surface, the barrel is located at least partially within the cavity, and the barrel slides within the cavity parallel to the longitudinal axis of the cavity;

the first end of the plunger is located within the barrel and is adapted to contact the liquid medication, the first end has a periphery, the periphery of the first end of the plunger forms a sliding seal with the inner surface of the barrel, the seal is liquid-tight, and the plunger slides with respect to the barrel parallel to the longitudinal axis of the plunger; and

the motion of the moving portion of the plunger section toward the skin surface expels the liquid medication from the reservoir and injects the liquid medication into the body of the patient.

23. The injector device according to claim 22, wherein the barrel is between the first end of the plunger and the cap, the cap and the barrel are not integrally attached, the inner surface of the cap is near the first end of the barrel, the motion of the cap toward the skin surface after the snap point is reached brings the inner surface of the cap into contact with the first end of the barrel, and the contact of the inner surface of the cap and the first end of the barrel drives the barrel toward the skin surface.

24. The injector device according to claim 1, wherein the cavity is gas-tight, the cavity contains a gas, the motion of the moving portion of the plunger section toward the skin surface after the snap point is reached compresses the gas within the cavity, and expansion of the gas after compression moves the moving portion of the plunger section back toward the initial position after injection of the parenteral medication.

25. The injector device according to claim 1, wherein the plunger section includes a spring, the motion of the moving portion of the plunger section toward the skin surface after the snap point is reached compresses the spring, and expansion of the spring after compression moves the moving portion of the plunger section back toward the initial position after injection of the parenteral medication.

26. The injector device according to claim 25, wherein the spring is a coil spring.

27. The injector device according to claim 26, wherein the coil spring is located within the cavity.

28. The injector device according to claim 26, wherein the coil spring is located between the second end of the plunger and the plunger end of the base.

29. The injector device according to claim 1, wherein the snap means includes at least one break tab, and the break tab is frangible.

30. The injector device according to claim 29, wherein the break tab breaks when the hand force is at least 10 N but not more than 40 N.

31. The injector device according to claim 29, wherein:

the plunger section includes a cap, the cap has a central section and a peripheral section, the central section is generally planar and has a periphery, the peripheral section is attached to the periphery of the central section and extends approximately perpendicular to the central section and toward the skin surface, each of the central and peripheral sections has an outer surface and an inner surface, the hand force is applied to the central section of the cap, and the moving portion of the plunger section includes the cap; and

the break tab includes at least one cap break tab, and the cap break tab projects from the inner surface of the peripheral section of the cap.

32. The injector device according to claim 31, wherein the cap break tab is adjacent to the plunger end of the base when the plunger section is in the initial position.

33. The injector device according to claim 32, wherein the peripheral section of the cap has a free end, the cap has at least one groove between the cap break tab and the free end of the peripheral section, the outer surface of the base has at least one base projection near the plunger end of the base, the base projection projects into the groove when the plunger section is in the initial position, and the base projection is adapted to prevent the cap from being removed from the base.

34. The injector device according to claim 32, wherein:

at least a part of the parenteral medication is a liquid medication;

the plunger section includes a barrel, the barrel is tubular and has a first end and a second end, the first end is at least partially closed, the barrel has a reservoir adapted to contain the liquid medication, the barrel has a longitudinal axis parallel to the longitudinal axis of the plunger, the barrel has an inner surface and an outer surface, the barrel is located at least partially within the cavity, and the barrel slides within the cavity parallel to the longitudinal axis of the cavity;

the first end of the plunger is located within the barrel and is adapted to contact the liquid medication, the first end has a periphery, the periphery of the first end of the plunger forms a sliding seal with the inner surface of the barrel, the seal is liquid-tight, and the plunger slides with respect to the barrel parallel to the longitudinal axis of the plunger; and

the motion of the moving portion of the plunger section toward the skin surface expels the liquid medication from the reservoir and injects the liquid medication into the body of the patient.

35. The injector device according to claim 34, wherein the break tab includes at least one barrel break tab, and the barrel break tab extends from the barrel toward the peripheral section of the cap when the plunger section is in the initial position.

36. The injector device according to claim 1, wherein the snap means includes at least one snap ring.

37. The injector device according to claim 36, wherein:

the plunger section includes a cap, the cap has a central section and a peripheral section, the central section is generally planar and has a periphery, the peripheral section is attached to the periphery of the central section and extends approximately perpendicular to the central section and toward the skin surface, each of the central and peripheral sections has an outer surface and an inner surface, the hand force is applied to the central section of the cap, and the moving portion of the plunger section includes the cap.

38. The injector device according to claim 37, wherein the snap means includes a cap snap ring, and the cap snap ring extends from the inner surface of the peripheral section of the cap.

39. The injector device according to claim 37, wherein the snap means includes a base snap ring, the base snap ring extends from the outer surface of the base near the plunger end of the base.

40. The injector device according to claim 36, wherein the snap means includes a plunger snap ring, the plunger snap ring is attached to the plunger and extends from the plunger toward the outer surface of the base, and the plunger snap ring is located near the first end of the plunger.

41. The injector device according to claim 36, wherein the snap means includes a plunger snap ring, the plunger snap ring is attached to the base and extends from the base toward the plunger, and the plunger snap ring is located near the plunger end of the base.

42. The injector device according to claim 1, wherein the injection means includes a glass needle.

43. The injector device according to claim 42, wherein the glass needle is composed at least partially of a glass selected from the group consisting of sugar glass, trehalose glass, trehalose octaacetate glass, glucose pentaacetate glass, silica glass, phosphate glass, metal carboxylate glass, and mannitol glass.

44. The injector device according to claim 43, wherein at least a part of the parenteral medication is incorporated into the glass.

45. The injector device according to claim 43, wherein the glass needle is tubular, and at least a part of the parenteral medication is contained in the interior of the glass needle.

46. The injector device according to claim 1, wherein the base and the plunger section are at least partially composed of plastic.

47. The injector device according to claim 46, wherein the base and the plunger section are composed of plastic.

48. The injector device according to claim 1, wherein:

the first end of the plunger is narrow, the cavity extends from the plunger end of the base to the nozzle end of the base, the first end of the plunger is blunt, and the first end of the plunger is located within the cavity when the plunger section is in the initial position; and

the injection means includes a glass needle, the glass needle is adapted to contain the parenteral medication, the glass needle is located within the cavity and between the plunger and the nozzle end of the base when the plunger section is in the initial position, and the motion of the moving portion of the plunger section after the snap point is reached drives the first end of the plunger toward the skin surface through the cavity, the first end of the plunger striking the glass needle and driving the glass needle through the skin surface, so that the glass needle remains in the body of the patient and dissolves in the body of the patient.

49. The injector device according to claim 1, wherein:

at least a part of the parenteral medication is a liquid medication; and

at least a part of the liquid medication is a suspension in perfluorocarbon.