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Multispecific chimeric receptors

  • US 6,103,521 A
  • Filed: 05/30/1995
  • Issued: 08/15/2000
  • Est. Priority Date: 02/06/1995
  • Status: Expired due to Fees
First Claim
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1. A DNA molecule encoding a chimeric membrane bound protein, said protein comprising in the N-terminal to C-terminal direction:

  • at least two extracellular inducer-responsive clustering domains in tandem to form a multispecific extracellular inducer-responsive clustering domain that binds specifically to at least one inducer molecule which results in the dimerization or oligomerization of said multispecific extracellular domain;

    a transmembrane domain; and

    a cytoplasmic signaling domain comprising a ζ

    or η

    chain of the T-cell receptor, or a Janus kinase,wherein when said membrane bound protein is expressed in a selected host cell under conditions suitable for expression, said membrane bound protein initiates a signal in said host cell on binding to said at least one inducer molecule.

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