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Capillary assays involving separation of free and bound species

  • US 6,103,537 A
  • Filed: 09/30/1998
  • Issued: 08/15/2000
  • Est. Priority Date: 10/02/1997
  • Status: Expired due to Term
First Claim
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1. A method for detecting the presence of an analyte in a sample employing capillary electroseparation in a microfluidic device where the binding of specific binding pair members results in an inhomogeneous complex, said method comprising:

  • combining in an assay mixture particles of uniform dimension to which one member of said specific binding pair is bound, said sample suspected of containing said analyte and a labeled compound which binds to said bound member of said specific binding pair or to said analyte;

    subjecting said assay mixture to capillary electroseparation to provide a sharp band of particles; and

    detecting labeled member bound to said particles, as indicative of the presence of said analyte.

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