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Dopamine receptor ligands

  • US 6,103,715 A
  • Filed: 08/25/1998
  • Issued: 08/15/2000
  • Est. Priority Date: 12/23/1993
  • Status: Expired due to Fees
First Claim
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1. A compound of Formula I:

  • ##STR30## wherein;

    A and B independently are both benzene optionally substituted with 1 or 2 substituents selected independently from hydroxyl, halo, selected independently from hydroxyl, halo, C1-4 alkyl, amino, nitro, cyano, halo-substituted C1-4 alkyl, C1-4 alkoxy, halo-substituted C1-4 alkoxy, C1-4 alkoxycarbonyl, C1-4 acyl, halo-substituted C1-4 acyl cyclo-C1-7 alkyl, thio-C1-4 alkylene, C1-4 alkylthio, halo-substituted C1-4 alkylthio, cyanothio, tetrazolyl, N-piperidinyl, N-piperazinyl, N-morpholinyl, acetamido, C1-4 alkylsulfonyl, halosulfonyl, halo-substituted C1-4 alkylsulfonyl, C1-4 alkylsulfoxyl, sulfonamido C1-4 alkylseleno, and OSO3 H;

    X1 is selected from NH, N--C1-4 alkyl and N-acetyl,X2 is N=Y is selected from CH and N;

    R1 represents C1-4 alkyl;

    n is 0, 1 or 2;

    q is 1 or 2;

    R2 is C1-6 alkylene optionally incorporating an intervening or terminating heteroatom selected from N, O and S;

    D is cyclohexane or benzene; and

    E is a saturated or unsaturated 5- or 6-membered heterocycle incorporating 1, 2 or 3 heteroatoms selected from O, N, and S, wherein E is optionally substituted with 1 or 2 substituents selected from halogen, C1-4 alkyl and halogen-substituted C1-4 alkyl;

    and acid addition salts, solvates or hydrates thereof.

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