PH-sensitive polymer containing sulfonamide and its synthesis method
First Claim
1. A method for preparing sulfonamide group-containing pH-sensitive polymers, in which sulfonamide derivatives are converted into polymerizable sulfonamide monomers, and coupled directly to polymers or copolymerized with other monomers.
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Abstract
There are disclosed pH-sensitive polymers containing sulfonamide groups, which can be changed in physical properties, such as swellability and solubility, depending on pH and which can be applied for a drug-delivery system, bio-material, sensor, etc, and a preparation method therefor. The pH-sensitive polymers are prepared by introduction of sulfonamide groups, various in pKa, to hydrophilic groups of polymers either through coupling to the hydrophilic groups, such as acrylamide, N,N-dimethylacrylamide, acrylic acid, N-isopropylacrylamide, etc, of polymers or copolymerization with other polymerizable monomers. These pH-sensitive polymers may have a structure of linear polymer, grafted copolymer, hydrogel or interpenetrating network polymer.
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5 Claims
- 1. A method for preparing sulfonamide group-containing pH-sensitive polymers, in which sulfonamide derivatives are converted into polymerizable sulfonamide monomers, and coupled directly to polymers or copolymerized with other monomers.
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