Method and apparatus for treating subcutaneous histological features

• US 6,104,959 A
• Filed: 07/31/1997
• Issued: 08/15/2000
• Est. Priority Date: 07/31/1997
• Status: Expired due to Fees

• Current Assignee: Microwave Medical Corp. (Dynamic Associates, Inc.), miraDry, Inc. (Sientra Incorporated)
• Original Assignee: Microwave Medical Corp. (Dynamic Associates, Inc.)
• Inventors: Spertell, Robert Bruce
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): CARTER, RYAN CHRISTOPHER
• Application Number:
  US08/904,175
• Time in Patent Office: 1,111 Days
• Field of Search: 607/100-102, 607/115, 607/154, 607/156, 606/27-34, 606/41-42, 606/9-13, 128/898
• US Class Current: 607/101
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00029 open
• CPC Class Codes: A61B 2018/00035 with return means
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61N 2005/007 for cooling the patient
• CPC Class Codes: A61N 5/025 Warming the body, e.g. hyperthermia treatment
• CPC Class Codes: A61N 5/04 Radiators for near-field treatment

Abstract

A system and method for treating subcutaneous histological features without affecting adjacent tissues adversely employs microwave energy of selected power, frequency and duration to penetrate subcutaneous tissue and heat target areas with optimum doses to permanently affect the undesirable features. The frequency chosen preferentially interacts with the target as opposed to adjacent tissue, and the microwave energy is delivered as a short pulse causing minimal discomfort and side effects. By distributing microwave energy at the skin over an area and adjusting power and frequency, different conditions, such as hirsuitism and telangiectasia, can be effectively treated.

Claims

1. The method of effecting a pathological change with microwave energy in a subsurface area below human skin level without damaging the skin itself comprising the steps of:

delivering, toward the skin surface adjacent the subsurface area, a pulse of microwave radiation in the frequency range of 10-20 GHz at an energy level and for a time sufficient to deliver 10-30 Joules of energy;

shaping the radiation pattern of the pulse to distribute substantial energy throughout an area of greater than about 20 mm² ; and

cooling the skin'"'"'s surface during at least a portion of the pulse delivery interval period.

2. The method as set forth in claim 1, above, wherein the pulse duration is less than 200 milliseconds, and wherein the subsurface area is raised to a temperature in the range of about 55°

C. to 70°

C.

3. The method as set forth in claim 2, above, wherein the pulse of microwave radiation is delivered to the skin surface across a transmission distance in excess of about 0.05 cm, and further including the step of injecting coolant in the transmission distance and against the skin surface.

4. The method as set forth in claim 3, above, wherein the coolant is delivered by expending a compressed gas in the volume including the transmission distance.

5. The method as set forth in claim 2, above, wherein the surface is cooled by conducting heat away from the surface by contact.

6. The method of effecting pathological change in a subcutaneous histological target region by external application comprising the steps of:

selecting a microwave frequency in the range of 10-20 GHz in which the loss factor for the histological target is greater than that for skin;

generating a signal at the selected microwave frequency;

propagating the generated microwave signals onto an area of the skin adjacent the subcutaneous region and greater than about 20 mm² in area while spreading the signal energy across the chosen area of the skin; and

maintaining the propagated signals for a time and until the impinging signal energy has reached a magnitude of about 10 to 30 Joules.

7. The method as set forth in claim 6, above, further including the step of cooling the chosen area of the skin during at least a portion of the duration of the interval of application of the microwave signals.

8. The method as set forth in claim 6, wherein the step of propagating microwave signals onto an area of the skin is effected by launching the microwave energy at a selected spacing from the skin surface, and wherein the skin cooling is effected by injecting a cooling gas into the space between the point of launching and the skin surface.

9. A method as set forth in claim 6, above, wherein the microwave frequency is about 14 GHz, wherein the chosen area of the skin is in the range of 20 to 125 mm² and wherein the gap between the point of launching and the skin surface is in the range of 0.25 to 0.75 mm.

10. A method as set forth in claim 6, above, wherein the target region comprises a plurality of hair follicles in the chosen area, and wherein the energy delivered is in the range of 10 to 20 Joules.

11. A method as set forth in claim 6, above, wherein the target region comprises blood vessels at depths of about 5 mm or less and wherein the energy delivered is in the range of 20-30 Joules.

12. A method as set forth in claim 6, above, further including the steps of preliminarily determining the reflected energy loss for the selected frequency, and tuning the frequency to reduce the reflection to less than about 5%.