Chronically implantable blood vessel cuff with sensor

• US 6,106,477 A
• Filed: 12/28/1998
• Issued: 08/22/2000
• Est. Priority Date: 12/28/1998
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Miesel, Keith A., Stylos, Lee
• Primary Examiner(s): Gilbert, Samuel G.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/221,059
• Time in Patent Office: 603 Days
• Field of Search: 600/486, 600/485, 600/488, 600/504, 623/1
• US Class Current: 600/486
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/6876 Blood vessel
• CPC Class Codes: A61B 5/6884 Clamps or clips

Abstract

A system for chronically measuring a physiologic parameter by an implantable device which has several forms is described. At its core a fixture for holding on to a blood vessel and forcing a sensor against a surface of the vessel is taught. Numerous adaptations and uses with various sensors are described.

Claims

1. A chronically implantable sensor device having tubular assembly with a first and second end and having a substantially circular passageway extending fully there through from said first to said second ends forming a passageway through said tubular assembly such that the internal surface of the passageway is coextensive with the external surface of the tubular assembly and wherein a slit extends along the axial length of the passageway from one opening of the passageway at said first end to another opening end of the passageway at said second end thus, said slit providing an access opening from said first opening end to said second opening end through said passageway wall and wherein on the interior surface of the passageway in said device, opposite from said slit, the interior surface has a substantially flat area into which a sensor is mounted.

17. An implantable medical device as set forth in any of claims 1-14 further comprising a cover member for covering said slit after a vessel has been secured in said tube.

18. An implantable medical device as set forth in any of claims 1-14 further comprising a cover member for covering said slit after a vessel has been secured in said tube, and wherein said cover member is a spring clip.

2. An implantable sensor fixture for chronic implant into a living body for chronically sensing physiologic measurement values within vessels of said body comprising a hard and substantially round interior tunnel shaped passageway for surrounding such a body vessel, having an interior space with a flat side and an slit side separate from said flat side, and having a sensor mounted into said interior of said tunnel for sensing said physiologic measurement values from within said vessel, and wherein a diameter of the interior tunnel shaped passage is measured as if said interior tunnel shaped passageway were closed across said slit side is slightly smaller than the normal external diameter of said vessel, thus causing said vessel to bulge slightly into an opening formed by said slit.

3. A fixture as set forth in claim 2 wherein said sensor is mounted into the flat side of said tunnel shaped passageway.

9. An implantable medical device comprising a fixture as set forth in claim 2 wherein said medical device further comprises

a sensor embedded into said fixture so as to be able to sense a physiologic condition in said vessel, wherein said sensor may sense a physiologic condition chosen from the list comprising;

pressure,

temperature,

blood oxygen saturation,

fluid flow,

fluid viscosity,

Doppler,

impedance.

10. An implantable medical device comprising a fixture as set forth in claim 2 wherein said medical device further comprises

a sensor embedded into said fixture so as to be able to sense a physiologic condition in said vessel, wherein said sensor may sense a physiologic condition by employing a transducer chosen from the list comprising;

pressure,

temperature,

optical,

Doppler,

impedance,

electromagnetism.

11. An implantable device as set forth in any of claims 2-10, wherein a plurality of sensors are arrayed within said fixture on an inner surface of said tunnel so as to be responsive to physiological conditions within a vessel when said vessel is within said tunnel.

32. An implantable medical device as set forth in claim 11 wherein said sensor is mounted in a sensor capsule mated to said tube.

33. An implantable medical device as set forth in claim 32 and said sensor capsule further comprises a power source for powering said sensor.

34. An implantable medical device as set forth in claim 32 and wherein said sensor comprises a Doppler transducer and receiver.

35. An implantable medical device as set forth in claim 34 wherein said Doppler transducer is mounted across said tube from said receiver.

36. An implantable medical device as set forth in claim 32 and wherein said sensor comprises:

infrared and red wavelength transmitters and a light measuring receiver.

37. An implantable medical device as set forth in claim 32 and wherein said sensor comprises:

a plurality of electrodes extending from said capsule.

38. An implantable medical device as set forth in claim 32 wherein at least one of said electrodes not contact said vessel, but instead connects to a conductor in said tube which in turn is connected to an electrode located on an inner surface of said tube for contacting said vessel.

39. An implantable medical device as set forth in claim 32 and wherein said sensor comprises:

a plurality of resistive elements, at least one of which can operate as a heater and another at least one of which can operate as a temperature sensor.

4. A fixture as set forth in clam 2 wherein said sensor is a pressure sensor.

5. An implantable medical device comprising a fixture as set forth in claim 4 wherein said pressure sensor has a pressure membrane plate surface coextensive with said flat side.

6. An implantable medical device comprising a fixture as set forth in claim 4 wherein said pressure sensor has a membrane plate means spaced apart form said flat surface by a tub member filled with a pressure transmission medium.

7. An implantable medical device as set forth in claim 6 and further comprising a circuit for reading said pressure sensor measurements and a memory circuit for storing said pressure sensor measurements.

8. An implantable medical device as set forth in claim 7 further comprising a reference sensor housed near said fixture but not in contact with said tunnel shaped passageway, for measuring pressure in said living body substantially unaffected by pressure in said vessel.

12. An implantable medical device comprising

a tube having a slit on one side thereof and a flat surface on a side other than said one side,

a sensor mounted for contact with a blood vessel to be held in place within said tube,

circuit means for reading signals produced by said sensor.

13. An implantable medical device as set forth in claim 12 wherein said sensor is mounted on said flat surface.

15. An implantable medical device as set forth in any of claims 12-14 wherein said tube has two opening sides and a middle portion, and wherein said middle portion is narrower than said opening sides.

16. An implantable medical device as set forth in any of claims 12-14 wherein said slit is not straight.

19. A chronically implantable medical device system comprising a first housing containing electronic circuits, said first housing spaced apart from a second implantable medical device as set forth in claim 12 and having a connection means for transferring signals from said sensor in said second implantable medical device to said electronic circuits in said first housing.

20. A chronically implantable medical device system as set forth in claim 19 wherein said connection means comprises a medical lead linking said first housing electronic circuits to said sensor.

21. A chronically implantable medical device system as set forth in claim 20 wherein said medical lead comprises two conductors at least one of which is coiled.

22. A chronically implantable medical device system as set forth in claim 20 wherein said medical lead comprises an optical pathway linking said first housing electronic circuits to said sensor.

23. An implantable medical device system as set forth in claim 19 wherein said first housing houses an implantable drug pump.

24. An implantable medical device system as set forth in claim 19 wherein said first housing houses a memory storage circuit for storing information related to said sensor signals.

25. An implantable medical device system as set forth in claim 19 wherein said first housing houses a memory storage circuit for storing information related to said sensor signals for later uplinking said information to an external device.

26. An implantable medical device as set forth in claim 25 further comprising a telemetry circuit means and processing circuit for uplinking information related to measurement made by said sensor means from said memory circuit to a device outside a body into which said implantable device may be implanted.

27. An implantable medical device system as set forth in claim 19, wherein said first housing houses a medical interventional device capable of delivering therapy to a body into which it may be implanted and further comprising a processing circuit for processing signals from said sensor so as to enable said processor circuit to alter therapy delivery characteristics by said medical interventional device.

28. An implantable medical device system as set forth in claim 19, wherein a processor associated with said memory can set a data flag in said memory based on measurements made by said sensor.

29. An implantable medical device system as set forth in claim 19, wherein a processor associated with said memory can trigger an alarm based on measurements made by said sensor.

30. An implantable medical device system as set forth in claim 19, having a plurality of second implantable medical devices for location at a plurality of regions in the body.

31. An implantable medical device system as set forth in claim 30 wherein said plurality of second implantable medical devices all measure blood pressure.

14. An implantable medical device comprising a tube constructed of materials substantially inflexible relative to blood vessel flexibility, and having a slit along one side thereof and a sensor mounted internally to said tube on a side other than said one side.

40. A sensor assembly for long term monitoring of conditions in a blood vessel of a living body comprising a rigid fixture for holding a blood vessel and a sensor capsule mated to said fixture.

41. A sensor assembly for long term monitoring of a condition in a blood vessel of a living body comprising a rigid fixture for holding a blood vessel having an interior surface for contacting said blood vessel outer wall, and having a sensor mounted on said interior surface so as to be in operative contact with said external wall of said blood vessel when in use.

42. A chronically implantable medical device comprising a fixture comprising a tube having two open ends and a slit opening through which to pass a blood vessel, and having mounted therein an optical sensor mounted so as to face an inner surface of said tube and to thus be in contact with said blood vessel, wherein said optical sensor comprises a light transmission means for transmitting light of more than one wavelength and a light sensitive means for measuring light returned.

43. An implantable medical device as set forth in claim 42 wherein at least a portion of said inner surface is reflective.