Therapeutic microdevices and methods of making and using same
First Claim
1. A suspension of microdevices for use in delivering a therapeutic compound to the interstitial space of a target region which is characterized by a target-specific marker on a basement membrane forming a vasculature of the target region, comprisinga suspension of microdevices in an aqueous medium, said microdevices (i) having a selected non-spherical shape, uniform dimensions and a selected maximum dimension in a range of 0.1 and 3 microns and (ii) composed of at least two separate bodies, including a support having at least one planar surface, and a therapeutic agent attached to the support, said therapeutic agent being in a form such that the activity of the therapeutic agent is expressed in direct response to a chemical or biochemical interaction that occurs upon exposure of the microdevice to a biochemical environment of a target site after administration of the microdevices to a subject, said microdevices containing a surface-bound marker-binding molecule effective to bind to such marker, and an enzyme effective to lyse the basement membrane.
1 Assignment
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Accused Products
Abstract
A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am range. Also disclosed are microfabrication methods for making such microdevices.
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Citations
7 Claims
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1. A suspension of microdevices for use in delivering a therapeutic compound to the interstitial space of a target region which is characterized by a target-specific marker on a basement membrane forming a vasculature of the target region, comprising
a suspension of microdevices in an aqueous medium, said microdevices (i) having a selected non-spherical shape, uniform dimensions and a selected maximum dimension in a range of 0.1 and 3 microns and (ii) composed of at least two separate bodies, including a support having at least one planar surface, and a therapeutic agent attached to the support, said therapeutic agent being in a form such that the activity of the therapeutic agent is expressed in direct response to a chemical or biochemical interaction that occurs upon exposure of the microdevice to a biochemical environment of a target site after administration of the microdevices to a subject, said microdevices containing a surface-bound marker-binding molecule effective to bind to such marker, and an enzyme effective to lyse the basement membrane.
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5. A suspension of microdevices for use in administering a therapeutic agent to a selected target site in a subject, comprising
a suspension of microdevices in an aqueous medium, said microdevices (i) having a selected non-spherical shape and uniform dimensions and (ii) composed of at least two separate bodies, including a support having at least one planar surface, and a therapeutic agent attached to the support, said therapeutic agent being in a form such that an activity of the therapeutic agent is expressed in direct response to a chemical or biochemical interaction that occurs upon exposure of the microdevice to a biochemical environment of the target site after administration of the microdevices to the subject, wherein the microdevices are substantially disc-shaped, and have a laminated structure containing first and second disc-shaped layers forming said support and therapeutic agent, respectively.
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7. A suspension of microdevices for use in administering a therapeutic agent to a selected target site in a subject, comprising
a suspension of microdevices in an aqueous medium, said microdevices (i) having a selected non-spherical shape and uniform dimensions and (ii) composed of at least two separate bodies, including a support having at least one planar surface, and a therapeutic agent attached to the support, said therapeutic agent being in a form such that an activity of the therapeutic agent is expressed in direct response to a chemical or biochemical interaction that occurs upon exposure of the microdevice to a biochemical environment of the target site after administration of the microdevices to the subject, wherein the microdevices have substantially disk-shaped supports having radially-disposed regions which contain said therapeutic agent.
Specification