Method and apparatus for detecting changes in electrocardiogram signals

• US 6,108,577 A
• Filed: 04/26/1999
• Issued: 08/22/2000
• Est. Priority Date: 04/26/1999
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Benser, Michael Eric
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/299,507
• Time in Patent Office: 484 Days
• Field of Search: 600/509, 600/515, 600/517, 600/521
• US Class Current: 600/517
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/353 Detecting P-waves
• CPC Class Codes: A61B 5/355 Detecting T-waves
• CPC Class Codes: A61B 5/358 Detecting ST segments
• CPC Class Codes: A61B 5/36 Detecting PQ interval, PR interval or QT interval
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

Method and apparatus for detecting changes in electrocardiogram signals. A first cardiac electrogram signal is sensed, where the first cardiac electrogram signal has a voltage and includes a first cardiac complex. A ventricular activation is detected in the first cardiac complex and a first timer is started, where the first timer times a first specified time. A first voltage value is measured from the first cardiac electrogram signal at the first specified time after the ventricular activation. A second voltage value is also measured from a defined portion of the first cardiac electrogram signal. A comparison value is then calculated from the first and second voltage values measured from the first cardiac electrogram signal. The first voltage value is recorded when the comparison value is greater than or equal to a predetermined value.

Claims

1. A method, comprising:

sensing a first cardiac electrogram signal, where the first cardiac electrogram signal has a voltage and includes a first cardiac complex;

detecting an occurrence of a ventricular activation from the first cardiac complex;

measuring a first voltage value of the first cardiac electrogram signal at a first specified time after the ventricular activation determined from the first cardiac complex;

measuring a second voltage value at a defined portion of the first cardiac electrogram signal;

calculating a comparison value from the first and second voltage values; and

recording the first voltage value when the comparison value is greater than or equal to a predetermined value.

2. The method of claim 1, wherein measuring the second voltage value includes measuring the second voltage value between a P-wave and a Q-wave of the first cardiac complex;

and

calculating the comparison value includes subtracting the second voltage value from the first voltage value.

3. The method of claim 1, including sensing a second cardiac complex in the first cardiac signal, wherein the second cardiac complex precedes the first cardiac complex;

calculating a ventricular activation interval from the first cardiac complex and the second cardiac complex; and

calculating the first specified time by taking a predetermined percentage of the ventricular activation interval.

4. The method of claim 3, wherein the predetermined percentage is between approximately 2 and 50 percent of the ventricular activation interval.

5. The method of claim 1, including sensing a second cardiac complex in the first cardiac electrogram signal;

determining an occurrence of the ventricular activation from the second cardiac complex;

measuring the second voltage value at the first specified time after the ventricular activation determined from the second cardiac complex;

calculating the comparison value from the first and second voltage values by calculating a rate of voltage change between the first and second voltage values.

6. The method of claim 1, including sensing a second cardiac complex in the first cardiac electrogram signal;

detecting an occurrence of the ventricular activation from the second cardiac complex;

measuring the first voltage value of the first cardiac electrogram signal at the first specified time after the ventricular activation determined from the second cardiac complex;

measuring the second voltage value at the defined portion of the first cardiac electrogram signal from the first cardiac complex;

measuring the second voltage value at the defined portion of the first cardiac electrogram signal from the second cardiac complex;

calculating the comparison value for the first cardiac complex from the first and second voltage values measured from the first cardiac complex;

calculating the comparison value for the second cardiac complex from the first and second voltage values measured from the second cardiac complex;

calculating a rate of voltage change between the comparison value for the first cardiac complex and the comparison value for the second cardiac complex; and

recording the first voltage value of both the first cardiac complex and the second cardiac complex when the rate of voltage change is greater than or equal to the predetermined value.

7. The method of claim 1, wherein determining the occurrence of ventricular activation includes sensing a near-field electrogram signal, where a maximum deflection point of the near-field electrogram signal sensed for the cardiac complex is taken as the occurrence of the ventricular activation.

8. The method of claim 7, wherein the first specified time after the ventricular activation is a predetermined value in the range of between 20 and 500 milliseconds.

9. The method of claim 1, including starting a first timer, wherein the first timer counts off a first predetermined time;

and

wherein measuring the first voltage value includes measuring the first voltage value once the first predetermined time expires.

10. The method of claim 9, including starting a second timer when the comparison value is greater than or equal to the predetermined value, wherein the second timer overrides the first timer and wherein the second timer counts off a second predetermined time that has a shorter duration than the first predetermined time;

calculating the comparison value from the first and second voltage values once the second predetermined time expires; and

restarting the second timer when the comparison value is greater than or equal to the predetermined value.

11. The method of claim 9, including starting a second timer when the comparison value is greater than or equal to the predetermined value, wherein the second timer counts off a second predetermined time that is of a shorter duration than the first predetermined time;

starting a duration timer, where the duration timer times an interval over which the second time period overrides the first time period; and

calculating the comparison value from the first and second voltage values once the second predetermined time expires; and

restarting the second timer once the second predetermined time expires for the interval of the duration timer.

12. The method of claim 1, wherein measuring the first voltage value includes acquiring two or more voltages of the first cardiac electrogram signal at a predetermined sampling frequency between the first specified time and a second specified time after the occurrence of the ventricular activation;

and

calculating the first voltage value from the two or more voltages.

13. The method of claim 1, including sensing a plurality of cardiac complexes in the first cardiac electrogram signal;

and

plotting the recorded voltage of each cardiac complex from the plurality of cardiac complexes as a function of time.

14. The method of claim 1, including positioning a first electrode in an intrathoracic space;

positioning a second electrode in a thoracic cavity; and

sensing the first cardiac signal between the first electrode and the second electrode.

15. The method of claim 1, including positioning a first electrode in a coronary vein;

positioning a second electrode in a thoracic cavity; and

sensing the first cardiac signal across the left ventricle between the first electrode and the second electrode.

16. The method of claim 1, including recording the first voltage value when the comparison value is less than the predetermined value.

17. An implantable cardiac rhythm management device, comprising:

a connector block having at least a first input/output socket; and

control circuitry within an implantable housing, the control circuitry including;

a ventricular activation detector circuit coupled to the first input/output socket, where the ventricular activation detector circuit receives a first cardiac signal through the first input/output socket and analyzes the first cardiac signal for the occurrence of a ventricular activation in a first cardiac complex;

a cardiac morphology detector circuit coupled to the first input/output socket, wherein the cardiac morphology detector circuit is coupled to the ventricular activation detector circuit, and wherein the cardiac morphology detector circuit receives the first cardiac signal through the first input/output socket, analyzes the first cardiac signal for the occurrence of the first cardiac complex, measures a first voltage value from the first cardiac signal at a first specified time after the ventricular activation in the first cardiac complex, and measures a second voltage value of the first cardiac electrogram signal at a defined portion of the first cardiac complex;

a cardiac data processing circuit coupled to the ventricular activation detector circuit and the cardiac morphology detector circuit, wherein the cardiac data processing circuit calculates a comparison value from the first and second voltage values; and

a microcontroller coupled to the cardiac data processing circuit the ventricular activation detector circuit and the cardiac morphology detector circuit, wherein a memory circuit is coupled to the microcontroller and wherein the microcontroller receives the comparison value from the cardiac data processing circuit and records the first voltage value in the memory when the comparison value is greater than or equal to a predetermined value.

18. The implantable cardiac rhythm management device of claim 17, wherein the cardiac morphology detector circuit measures the second voltage value between a P-wave and a Q-wave of the first cardiac complex.

19. The implantable cardiac rhythm management device of claim 17, wherein the ventricular activation detector circuit analyzes the first cardiac signal for the occurrence of ventricular activation in a second cardiac complex, wherein the second cardiac complex precedes the first cardiac complex;

the cardiac morphology detector circuit calculates a ventricular activation interval from the ventricular activation of the first cardiac complex and the ventricular activation of the second cardiac complex, and calculates the first specified time by taking a predetermined percentage of the ventricular activation interval.

20. The implantable cardiac rhythm management device of claim 17, wherein the ventricular activation detector circuit analyzes the first cardiac signal for the occurrence of ventricular activation in a second cardiac complex;

the cardiac morphology detector circuit analyzes the first cardiac signal for the occurrence of the second cardiac complex, measures the second voltage value from the first cardiac signal at the first specified time after the ventricular activation in the second cardiac complex; and

the cardiac data processing circuit calculates the comparison value as a rate of voltage change between the first and second voltage values.

21. The implantable cardiac rhythm management device of claim 17, wherein the ventricular activation detector circuit analyzes the first cardiac signal for the occurrence of ventricular activation in a second cardiac complex;

the cardiac morphology detector circuit analyzes the first cardiac signal for the occurrence of the second cardiac complex, measures the first voltage value of the first cardiac signal at the first specified time after the ventricular activation in the second cardiac complex, measures the second voltage value at the defined portion of the first cardiac signal from the first cardiac complex, and measures the second voltage value at the defined portion of the first cardiac signal from the second cardiac complex;

the cardiac data processing circuit calculates the comparison value for the first cardiac complex from the first and second voltage values measured from the first cardiac complex, calculates the comparison value for the second cardiac complex from the first and second voltage values measured from the second cardiac complex, and calculates a rate of voltage change between the comparison value for the first cardiac complex and the comparison value for the second cardiac complex; and

the microcontroller records the first voltage value of both the first cardiac complex and the second cardiac complex when the rate of voltage change is greater than or equal to the predetermined value.

22. The implantable cardiac rhythm management device of claim 17, wherein the first specified time after the ventricular activation is a predetermined value in the range of between 20 and 500 milliseconds.

23. The implantable cardiac rhythm management device of claim 17, wherein the microcontroller contains a first timer which counts off a first predetermined time, and signals the ventricular activation detector circuit and the cardiac morphology detector circuit to analyze the first cardiac signal for the occurrence of the ventricular activation in the first cardiac complex, to measure the first voltage value, and to measure the second voltage value after the first predetermined time expires.

24. The implantable cardiac rhythm management device of claim 23, wherein the microcontroller contains a second timer which overrides the first timer and counts off a second predetermined time, the second predetermined time having a shorter duration than the first predetermined time, and wherein the microcontroller starts the second timer when the comparison value is greater than or equal to the predetermined value such that the microcontroller signals the ventricular activation detector circuit and the cardiac morphology detector circuit to analyze the first cardiac signal for the occurrence of the ventricular activation in the first cardiac complex, to measure the first and second voltage values after the second predetermined time expires, and the microprocessor restarts the second timer when the comparison value is greater than or equal to a predetermined value.

25. The implantable cardiac rhythm management device of claim 23, wherein the microcontroller contains a duration timer which counts off a duration interval and a second timer which counts of a second predetermined time, where the second timer functions to override the first timer and where the second predetermined time has a shorter duration than the first predetermined time, and wherein the microcontroller starts the duration timer and the second timer when the comparison value is greater than or equal to the predetermined value such that the microcontroller signals the ventricular activation detector circuit and the cardiac morphology detector circuit to analyze the first cardiac signal for the occurrence of the ventricular activation in the first cardiac complex, to measure the first and second voltage values after the second predetermined time expires, and the microprocessor restarts the second timer once the second predetermined time expires for the interval of the duration timer.

26. The implantable cardiac rhythm management device of claim 17, where the cardiac morphology detector circuit measures two or more voltages of the first cardiac electrogram signal at a predetermined sampling frequency between the first specified time and a second specified time after the occurrence of the ventricular activation, and calculates the first voltage value of the first cardiac electrogram signal from the two or more voltages.