Method of treating addiction by brain infusion

• US 6,109,269 A
• Filed: 04/30/1999
• Issued: 08/29/2000
• Est. Priority Date: 04/30/1999
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Graves, Nina, Rise, Mark T.
• Primary Examiner(s): Yu, Mickey
• Assistant Examiner(s): CAMPEN, KELLY SCAGGS
• Application Number:
  US09/303,182
• Time in Patent Office: 487 Days
• Field of Search: 128/898, 607/2, 607/117, 607/45, 607/46, 607/48, 604/890.1, 604/891.1, 604/20, 604/65-67, 574/25, 600/595
• US Class Current: 128/898
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system

Abstract

Techniques using one or more drugs, electrical stimulation or both to treat addictions by means of an implantable signal generator and electrode and an implantable pump and catheter. A catheter is surgically implanted in selected sites in the brain to infuse the drugs, and one or more electrodes are surgically implanted in the brain at selected sites to provide electrical stimulation.

Claims

1. A method of using one or more drugs to therapeutically treat addictive disorders by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, as well as an electric signal generator and an implantable electrode having a proximal end and a stimulation portion, the method comprising the steps of:

surgically implanting the electrode so that the stimulation portion lies adjacent a predetermined stimulation site in brain tissue, the stimulation site chosen as a location that, when electrically stimulated, reduces symptoms of addictive disorders;

surgically implanting the catheter so that the discharge portion lies adjacent a predetermined infusion site in the brain tissue, the infusion site chosen as a location that, when therapeutic dosages of the one or more drugs are infused thereto, reduces symptoms of addictive disorders;

coupling the proximal end of the electrode to the signal generator;

operating the signal generator to stimulate the stimulation site;

operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site while the signal generator is stimulating the stimulation site, whereby addictive disorders are treated.

2. A method, as claimed in claim 1, wherein the stimulation site is selected from the group consisting of DORSAL MEDIAL THALAMUS, Pallido-thalamic axons (AL and LT), GPi/SNr, Subthalamic to pallidal fiber tracts, STN Nucleus, GPe, Neostriatum to Gpe fibers (i.e., border of nucleus), NUCLEUS ACCUMBENS and AMYGDALA.

3. A method, as claimed in claim 1, wherein the infusion site is selected from the group consisting of DORSAL MEDIAL THALAMUS, DORSAL MEDIAL THALAMUS, INTERNAL GLOBUS PALLIDUS (Gpi), SUBSTANTIA NIGRA RETICULATA (SNr), GPi/SNr, STN, EXTERNAL GLOBUS PALLIDUS (GPe), GPe, NUCLEUS ACCUMBENS, CENTRAL NUCLEUS OF THE AMYGDALA and LOCUS COERULEUS.

4. A method, as claimed in claim 1, wherein the one or more drugs is selected from the group consisting of GLUTAMATE ANTAGONIST, DEGRADING ENZYME, Anesthetic, ASPARTATE ANTAGONIST, GABA AGONIST, REUPTAKE BLOCKER, DEGRADING ENZYME BLOCKER, GLUTAMATE AGONIST, ASPARTATE AGONIST, GABA ANTAGONIST, DOPAMINE ANTAGONIST.

5. A method of using one or more drugs to therapeutically treat addictive disorders by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of:

surgically implanting the catheter so that the discharge portion lies adjacent a predetermined infusion site in the brain tissue, the infusion site chosen as a location that, when therapeutic dosages of the one or more drugs are infused thereto, reduces symptoms of addictive disorders; and

operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby the addictive disorders is treated.

6. A method as claimed in claim 5 wherein the infusion site is selected from the group consisting of DORSAL MEDIAL THALAMUS, DORSAL MEDIAL THALAMUS, INTERNAL GLOBUS PALLIDUS (Gpi), SUBSTANTIA NIGRA RETICULATA (SNr), GPi/SNr, STN, EXTERNAL GLOBUS PALLIDUS (GPe), GPe, NUCLEUS ACCUMBENS, CENTRAL NUCLEUS OF THE AMYGDALA and LOCUS COERULEUS.

7. A method as claimed in claim 6 wherein the one or more drugs is selected from the group consisting of GLUTAMATE ANTAGONIST, DEGRADING ENZYME, Anesthetic, ASPARTATE ANTAGONIST, GABA AGONIST, REUPTAKE BLOCKER, DEGRADING ENZYME BLOCKER, GLUTAMATE AGONIST, ASPARTATE AGONIST, GABA ANTAGONIST, DOPAMINE ANTAGONIST.

8. A method of using electrical stimulation to therapeutically treat addictive disorders by means of a signal generator and an implantable electrode having a proximal end and a stimulation portion, the method comprising the steps of:

surgically implanting the electrode so that the stimulation portion lies adjacent a predetermined stimulation site in brain tissue;

coupling the proximal end of the electrode to the signal generator; and

operating the signal generator to stimulate the stimulation site, whereby the addictive disorders is treated.

9. A method, as claimed in claim 8, wherein the stimulation site is selected from the group consisting of DORSAL MEDIAL THALAMUS, Pallido-thalamic axons (AL and LT), GPi/SNr, Subthalamic to pallidal fiber tracts, STN Nucleus, GPe, Neostriatum to Gpe fibers (i.e., border of nucleus), NUCLEUS ACCUMBENS and AMYGDALA.