Multimodality instrument for tissue characterization

• US 6,109,270 A
• Filed: 02/02/1998
• Issued: 08/29/2000
• Est. Priority Date: 02/04/1997
• Status: Expired due to Term

• Current Assignee: Administrator of The National Aeronautics and Space Administration, National Aeronautics and Space Administration Administrator of The US Government As Represented By The
• Original Assignee: United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration
• Inventors: Mah, Robert W., Andrews, Russell J.
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): ROLLINS, ROSILAND STACIE
• Application Number:
  US09/017,519
• Time in Patent Office: 939 Days
• Field of Search: 600/562, 600/564, 600/566, 600/567, 600/568, 606/1, 606/130, 128/920, 128/923, 128/924, 128/925
• US Class Current: 606/130
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 2017/00022 Sensing or detecting at the treatment site
• CPC Class Codes: A61B 2017/3409 including needle or instrument drives
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 34/32 operating autonomously
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/386 Accessories or supplementary instruments therefor
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/4218 characterised by articulated arms
• CPC Class Codes: A61B 90/06 Measuring instruments not otherwise provided for
• CPC Class Codes: A61B 90/10 : for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: A61B 90/11 : with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: Y10S 128/924 : using artificial intelligence

Abstract

A system with multimodality instrument for tissue identification includes a computer-controlled motor driven heuristic probe with a multisensory tip. For neurosurgical applications, the instrument is mounted on a stereotactic frame for the probe to penetrate the brain in a precisely controlled fashion. The resistance of the brain tissue being penetrated is continually monitored by a miniaturized strain gauge attached to the probe tip. Other modality sensors may be mounted near the probe tip to provide real-time tissue characterizations and the ability to detect the proximity of blood vessels, thus eliminating errors normally associated with registration of pre-operative scans, tissue swelling, elastic tissue deformation, human judgement, etc., and rendering surgical procedures safer, more accurate, and efficient. A neural network program adaptively learns the information on resistance and other characteristic features of normal brain tissue during the surgery and provides near real-time modeling. A fuzzy logic interface to the neural network program incorporates expert medical knowledge in the learning process. Identification of abnormal brain tissue is determined by the detection of change and comparison with previously learned models of abnormal brain tissues. The operation of the instrument is controlled through a user friendly graphical interface. Patient data is presented in a 3D stereographics display. Acoustic feedback of selected information may optionally be provided. Upon detection of the close proximity to blood vessels or abnormal brain tissue, the computer-controlled motor immediately stops probe penetration.

Claims

1. A system comprising in combination:

(a) an instrument including;

(i) a probe-cannula assembly formed of a multimodality probe and a cannula, with said probe being lodged at least in part within said cannula; and

(ii) one or more sensors and tools housed at least in part within said probe; and

(b) a computer system including;

(i) an instrument control unit for generating instructions to said instrument, said instrument control unit being connected to said instrument;

(ii) a neural network module for adaptively learning information derived by said instrument and for providing at least near real-time modeling;

(iii) a central processing unit for acquiring data from said instrument and said neural network module, and for processing signals to said instrument, and neural network module.

2. The system according to claim 1 including:

(c) a retention device,

(d) an actuator mechanism secured to said retention device, and attached to said probe-cannula so as to make said probe-cannula automatically drivable by said actuator mechanism,

(e) control circuitry for powering said actuator mechanism, and

(f) an instrument control unit within said computer system for generating instructions to said control circuitry.

3. The system according to claim 2, wherein said actuator mechanism includes two motors that automatically drive said probe inside said cannula, and that further advance said probe-cannula assembly in a predetermined direction.

4. The system according to claim 3, wherein said retention device is a stereotactic device for mounting on a subject.

5. The system according to claim 4, wherein said instrument further includes a mounting structure;

a guide mechanism;

a probe mounting plate; and

a cannula mounting plate.

6. The system according to claim 5, wherein said mounting structure includes a base that removably and adjustably mates with said retention device.

7. The system according to claim 6, wherein said guide mechanism includes at least one guide rail for allowing said probe mounting plate to journey slidably in a predetermined direction.

8. The system according to claim 1, wherein said computer system further includes a fuzzy logic interface to said neural network module, said fuzzy logic interface providing means for incorporating expert medical knowledge.

9. The system according to claim 4, wherein said neural net provides means for processing information derived by said instrument including any of:

tissue resistance, color, pressure, tissue reflectance.

10. The system according to claim 9, wherein said computer system further includes a three-dimensional graphics interface.

11. The system according to claim 8, wherein said neural network module provides means for identifying abnormal tissue by detecting a change of one or more factors relative to previously learned models of abnormal tissue.

12. The system according to claim 11, wherein said one or more sensors and tools are selected from a group comprising:

a strain gauge;

a wick in needle pressure sensor;

a laser Doppler blood flow sensor;

an ultrasound probe;

an endoscope;

a partial pressure of oxygen sensor;

an optical sensor;

a temperature sensor;

an ion specific sensor;

a microelectrode;

a tissue ablation laser;

an effector.

13. The system according to claim 12, wherein from said one or more sensors and tools an effector is selected and wherein said effector includes any one of:

biopsy forceps;

malleable biopsy forceps;

grasping forceps;

micro-scissors;

a coagulator;

an irrigator.

14. The system according to claim 13, wherein based on said derived information, said computer system provides means for determining whether it has detected tissue property changes or blood vessels.

15. The system according to claim 14, wherein if said computer system has detected tissue property changes said neural network module provides means for comparing said information to previously learned information and properties.

16. The system according to claim 15, wherein said neural network module is provided with means for being trained by any one or a combination of neural networks, and a fuzzy logic interface to said neural network module is used to incorporate expert medical knowledge in the learning process.

17. The system according to claim 16, wherein said neural networks are selected from the group comprising:

back propagation;

self organizing maps;

cerebellum model arithmetic computer;

radial basis function.

18. The system according to claim 17, wherein said neural network module provides means for adaptively learning information derived by said instrument by further:

developing one or more envelopes corresponding to one or more specific properties learned; and

identifying properties of abnormal tissue.

19. The system according to claim 18, wherein when said computer system provides means for identifying abnormal tissue by comparison with previously learned models of abnormal tissues.

20. The system according to claim 11, wherein said neural network module provides means for adaptively learning information derived by said instrument by:

advancing said probe-cannula assembly into normal tissue;

advancing said probe-cannula assembly toward a predetermined target site;

said computer system continually checking to determine whether changes in tissue properties or blood vessels have been detected;

if said computer system does not detect property changes or blood vessels, it instructs said probe-cannula assembly to continue its travel toward said target site; and

if said computer system detects property changes or blood vessels, it instructs said probe-cannula assembly to stop advancing.

21. The system of claim 1, said probe-cannula assembly configured such that said probe is removable from the cannula assembly during an application and replaceable by a second probe having replacement one or more sensors and tools.