Release rate modulator and method for producing and using same

• US 6,109,537 A
• Filed: 02/18/1999
• Issued: 08/29/2000
• Est. Priority Date: 02/18/1999
• Status: Expired due to Fees

• Current Assignee: United States Department Of Agriculture
• Original Assignee: United States Department Of Agriculture
• Inventors: Heath, Robert R.
• Primary Examiner(s): Morris, Lesley D.
• Application Number:
  US09/252,945
• Time in Patent Office: 558 Days
• Field of Search: 239/51.5, 239/49, 239/44, 239/56, 239/55, 239/53, 239/59, 239/58, 239/57, 239/6, 239/34, 43/107, 43/129, 43/131, 43/132.1, 428/905
• US Class Current: 239/6
• CPC Class Codes: A61L 9/042 with the help of a macromolecular compound as a carrier or diluent A61L9/048 takes precedence
• CPC Class Codes: A61L 9/12 Apparatus, e.g. holders, therefor

Abstract

A release rate modulator for use with membrane-based formulations systems to control the release of a substance. The release rate modulator is formed from perforated polypropylene containing approximately 36 holes/cm². Each hole is approximately 1 mm² in size. The flow of substance passes through the holes and the membrane before reaching the surrounding environment. The use of the modulator improves the duration of substance release and provides a more constant release of the substance compared to unpredictable release rates obtained when the formulations systems did not contain the modulator.

Claims

1. A device for releasing a volatile substance to a surrounding environment, comprising:

a. a receptacle having an interior for containing the substance, wherein the receptacle is formed from a material essentially nonpermeable to the substance with at least one first opening to allow communication between the interior of the receptacle and the surrounding environment;

b. a membrane selectively permeable to the volatile substance, wherein the membrane is contained within the receptacle;

c. a release rate modulator positioned between the membrane and the substance, wherein the modulator comprises a perforated plate with a plurality of holes; and

d. filter paper onto which the volatile substance is pipetted, wherein the filter paper is contained within the receptacle.

2. The device of claim 1, further comprising a tape covering with a second opening therethrough, wherein the tape covering is nonpermeable to the substance and is placed over the membrane with the second opening in communication with the first opening.

3. The device of claim 2, wherein the tape covering comprises a metal film.

4. The device of claim 3, wherein the metal film is an aluminum film.

5. The device of claim 2, wherein the second opening is smaller than the first opening.

6. The device of claim 1, wherein the receptacle comprises an envelope with two panels.

7. The device of claim 1, wherein the substance is a volatile material selected from the group consisting of insecticide compositions, herbicide compositions, perfume compositions, animal repellent compositions, air freshener compositions, pheromone compositions, odor maskant compositions, deodorant compositions, insect repellent compositions, compositions for the evaluation of olfactory functioning in humans as well as in animals and compositions for the treatment of disease of humans and animals through olfactory functioning.

8. The device of claim 1, wherein the membrane comprises a semipermeable membrane selected from the group consisting of high density polyethylene (HDPE) film and low density polyethylene (LDPE) film.

9. The device of claim 1, wherein the perforated plate comprises polypropylene.

10. The device of claim 1, wherein the perforated plate has a thickness between about 0.5 and 1.5 mm.

11. The device of claim 1, wherein the perforated plate is generally rectangular and the plurality of holes are distributed over the perforated plate in an array.

12. The device of claim 1, wherein the perforated plate is generally rectangular and the plurality of holes are distributed over the perforated plate diagonally.

13. The device of claim 1, wherein the perforated plate is generally circular and the plurality of holes are distributed over the perforated plate radially.

14. The device of claim 1, wherein the perforated plate is generally elliptic and the plurality of holes are distributed over the perforated plate radially.

15. The device of claim 1, wherein the plurality of holes are distributed over the perforated plate with a density between about 30 to 42 holes/cm².

16. The device of claim 1, wherein each of the plurality of holes is about 0.5 to 1.5 mm² in size cross-sectionally.

17. A device for transfer of a substance to a surrounding environment, comprising:

a. a receptacle containing the substance on filter paper, wherein the receptacle has at least one opening; and

b. a plate covering the substance on filter paper, wherein the plate has a plurality of holes providing channels for the substance to pass into the surrounding environment through the opening in a relatively consistent flow.

18. The device of claim 17 further comprising a membrane cooperating with the plate to modulate the passage of the substance, wherein the membrane is selectively permeable to the substance.

19. The device of claim 17, wherein the receptacle is formed from a material essentially nonpermeable to the substance.

20. The device of claim 17, wherein the plurality of holes are distributed over the plate with a density between about 30 to 42 holes/cm².

21. The device of claim 17, wherein each of the holes is about 0.5 to 1.5 mm² in size cross-sectionally.

22. The device of claim 17, wherein the plate has a thickness between about 0.5 and 1.5 mm.

23. A method for releasing a substance to a surrounding environment, comprising:

a. providing a receptacle having an interior adapted to contain the substance and at least one first opening between the interior and the surrounding environment;

b. loading the substance onto filter paper and placing the filter paper into the receptacle or installing filter paper into the receptacle and loading the substance onto the filter paper; and

c. installing a perforated plate having a plurality of holes therethrough, the perforated plate substantially covering the substance, whereby release of the substance from the interior of the receptacle through the at least one first opening is modulated by the perforated plate.

24. The method of claim 23, further comprising a step of positioning a membrane next to the perforated plate, wherein the membrane is selectively permeable to the substance.

25. The method of claim 23, further comprising a step of placing a film with a second opening on top of the first opening, wherein the second opening communicates with the first opening.

26. The method of claim 23, wherein the plurality of holes are distributed over the perforated plate with a density in the range of about 30 to 42 holes/cm².

27. The method of claim 23 wherein each of the plurality of holes is about 0.5 to 1.5 mm² in size cross-sectionally.

28. The method of claim 23, wherein the perforated plate has a thickness in the range of about 0.5 to 1.5 mm.