Anti-inflammatory-agent-loaded catheter and method for preventing tissue fibrosis

• US 6,110,155 A
• Filed: 04/30/1996
• Issued: 08/29/2000
• Est. Priority Date: 04/30/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Baudino, Michael D.
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): RODRIGUEZ, CRIS LOIREN
• Application Number:
  US08/643,145
• Time in Patent Office: 1,582 Days
• Field of Search: 604/265, 604/53, 604/93, 604/48, 604/19-22, 604/264, 604/891.1, 604/892.1, 604/890.1, 604/508, 604/93.01, 604/523
• US Class Current: 604/265
• CPC Class Codes: A61L 2300/222 Steroids, e.g. corticosteroids
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections

Abstract

At least a portion of a catheter which is intended to be in contact with bodily tissue for more than a nominal period of time is loaded with an anti-inflammatory agent such as dexamethasone sodium phosphate. The direct loading or compounding of the catheter with the agent resists inflammation and encapsulation of the catheter as a result of the tissue'"'"'s natural foreign-body response. The anti-inflammatory agent can be provided as a coating or bonded on the outside of the catheter or can be integrally compounded into the body of the catheter.

Claims

1. An infusion catheter having a body with an exterior surface and a distal end to be positioned adjacent to bodily tissue for the conduction of fluid thereto or therefrom, the distal end carrying dexamethasone sodium phosphate covalently bonded to the exterior surface at least at the distal end, the dexamethasone sodium phosphate forming the ultimate exterior surface of the catheter where the dexamethasone sodium phosphate is bonded to the body, the dexamethasone sodium phosphate to be leached therefrom when the distal end is in contact with bodily tissue and fluid to combat inflammation of the tissue and encapsulation of the catheter thereby.

2. An infusion catheter according to claim 1, wherein the body of the catheter is formed of a polymeric material, the anti-inflammatory agent being dispersed throughout the polymeric material.

3. An infusion catheter according to claim 2, wherein the polymeric material is selected from the group consisting of urethane and silicone.

4. An infusion catheter having a body with an exterior surface and a distal end to be positioned adjacent to bodily tissue for the conduction of fluid thereto or therefrom, the body and the exterior surface of the catheter being made of a polymeric material, the distal end having dexamethasone sodium phosphate covalently bonded directly to the polymeric material of the exterior surface at least at the distal end, the dexamethasone sodium phosphate forming the ultimate exterior surface of the catheter where the dexamethasone sodium phosphate is bonded to the body, the dexamethasone sodium phosphate to be leached into bodily tissue and fluid when the distal end is in contact with bodily tissue and fluid to combat inflammation of the tissue and encapsulation of the catheter thereby.

5. An infusion catheter according to claim 4, wherein the polymeric material is selected from the group consisting of urethane and silicone.