Anti-inflammatory-agent-loaded catheter and method for preventing tissue fibrosis
First Claim
1. An infusion catheter having a body with an exterior surface and a distal end to be positioned adjacent to bodily tissue for the conduction of fluid thereto or therefrom, the distal end carrying dexamethasone sodium phosphate covalently bonded to the exterior surface at least at the distal end, the dexamethasone sodium phosphate forming the ultimate exterior surface of the catheter where the dexamethasone sodium phosphate is bonded to the body, the dexamethasone sodium phosphate to be leached therefrom when the distal end is in contact with bodily tissue and fluid to combat inflammation of the tissue and encapsulation of the catheter thereby.
1 Assignment
0 Petitions
Accused Products
Abstract
At least a portion of a catheter which is intended to be in contact with bodily tissue for more than a nominal period of time is loaded with an anti-inflammatory agent such as dexamethasone sodium phosphate. The direct loading or compounding of the catheter with the agent resists inflammation and encapsulation of the catheter as a result of the tissue'"'"'s natural foreign-body response. The anti-inflammatory agent can be provided as a coating or bonded on the outside of the catheter or can be integrally compounded into the body of the catheter.
-
Citations
5 Claims
- 1. An infusion catheter having a body with an exterior surface and a distal end to be positioned adjacent to bodily tissue for the conduction of fluid thereto or therefrom, the distal end carrying dexamethasone sodium phosphate covalently bonded to the exterior surface at least at the distal end, the dexamethasone sodium phosphate forming the ultimate exterior surface of the catheter where the dexamethasone sodium phosphate is bonded to the body, the dexamethasone sodium phosphate to be leached therefrom when the distal end is in contact with bodily tissue and fluid to combat inflammation of the tissue and encapsulation of the catheter thereby.
- 4. An infusion catheter having a body with an exterior surface and a distal end to be positioned adjacent to bodily tissue for the conduction of fluid thereto or therefrom, the body and the exterior surface of the catheter being made of a polymeric material, the distal end having dexamethasone sodium phosphate covalently bonded directly to the polymeric material of the exterior surface at least at the distal end, the dexamethasone sodium phosphate forming the ultimate exterior surface of the catheter where the dexamethasone sodium phosphate is bonded to the body, the dexamethasone sodium phosphate to be leached into bodily tissue and fluid when the distal end is in contact with bodily tissue and fluid to combat inflammation of the tissue and encapsulation of the catheter thereby.
Specification