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Methods for fabricating microarrays of biological samples

DC
  • US 6,110,426 A
  • Filed: 12/30/1997
  • Issued: 08/29/2000
  • Est. Priority Date: 06/17/1994
  • Status: Expired due to Term
First Claim
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1. A method of forming a microarray of discrete analyte-assay regions on a solid support, where each discrete region in the microarray has a select(d, analyte-specific reagent, said method comprising,(a) loading a solution of a selected analyte-specific reagent in a reagent-dispensing device having an elongate capillary channel adapted to hold a quantity of the reagent solution and having a tip region at which the channel is open-sided and the solution in the channel forms a meniscus,(b) tapping the tip of the dispensing device against a solid support at a defined position on the surface, with an impulse effective to break the meniscus in the capillary channel and deposit a selected volume of solution on the surface, and(c) repeating steps (a) and (b) until said microarray is formed.

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