Osmotic drug delivery system
First Claim
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1. An osmotic pharmaceutical delivery system comprising (a) a semipermeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough;
- and (b) a composition within said wall, which composition comprises (i) a pharmaceutical agent that has a limited solubility in water or physiological environments;
(ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutical agent;
(iii) at least one non-swelling ostmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition, said composition being free of an agent that provides a physical force other than by osmotic pressure for delivering the pharmaceutical agent whereby the pharmaceutical agent is delivered through the passageway by osmosis rather than by another force.
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Abstract
An osmotic drug delivery system, preferably in tablet form, which dispenses a therapeutic agent having limited water solubility in solubilized form. The delivery system comprises a core that is free of swellable polymers and comprises nonswelling solubilizing agents and wicking agents. The solubilized therapeutic agent is delivered through a passageway in the semipermeable coating of the tablet.
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Citations
28 Claims
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1. An osmotic pharmaceutical delivery system comprising (a) a semipermeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough;
- and (b) a composition within said wall, which composition comprises (i) a pharmaceutical agent that has a limited solubility in water or physiological environments;
(ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutical agent;
(iii) at least one non-swelling ostmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition, said composition being free of an agent that provides a physical force other than by osmotic pressure for delivering the pharmaceutical agent whereby the pharmaceutical agent is delivered through the passageway by osmosis rather than by another force. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- and (b) a composition within said wall, which composition comprises (i) a pharmaceutical agent that has a limited solubility in water or physiological environments;
Specification