Mammalian cell surface antigens; related reagents
First Claim
Patent Images
1. An isolated or recombinant polynucleotide that:
- a) hybridizes under stringent hybridization conditions of at least 55°
C. and less than 400 mM salt to the open reading frame of SEQ ID NO;
1 or 3; and
b) encodes a polypeptide that;
i) is expressed on activated T cells; and
ii) specifically binds a polyclonal antibody generated against 12 contiguous amino acids of SEQ ID NO;
2 or 4.
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Abstract
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
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Citations
36 Claims
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1. An isolated or recombinant polynucleotide that:
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a) hybridizes under stringent hybridization conditions of at least 55°
C. and less than 400 mM salt to the open reading frame of SEQ ID NO;
1 or 3; andb) encodes a polypeptide that; i) is expressed on activated T cells; and ii) specifically binds a polyclonal antibody generated against 12 contiguous amino acids of SEQ ID NO;
2 or 4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An isolated or recombinant polynucleotide encoding a polypeptide that
has a conservative amino add substitution of a mature polypeptide of SEQ ID NO: - 2 or 4 that lacks an N terminal leader sequence.
- View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A recombinant or isolated polynucleotide that hybridizes to the open reading frame of SEQ ID NO:
- 1 or 3 under stringent hybridization and wash conditions of at least 55°
C., a salt concentration of less than 250 mM, and 50% formamide. - View Dependent Claims (31, 32, 33, 34, 35, 36)
- 1 or 3 under stringent hybridization and wash conditions of at least 55°
Specification