Method for diagnosing malignancy in pelvic tumors

• US 6,112,108 A
• Filed: 09/12/1997
• Issued: 08/29/2000
• Est. Priority Date: 09/12/1997
• Status: Expired due to Term

• Current Assignee: Medico International Inc.
• Original Assignee: Ramot University Authority For Applied Research and Industrial Development Limited
• Inventors: Akselrod, Solange, Tepper, Ron
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/928,472
• Time in Patent Office: 1,082 Days
• Field of Search: 600/407, 600/410, 600/419, 600/454, 600/457, 600/504, 600/310, 600/455, 600/425, 600/427, 600/431, 600/436, 600/411, 600/473, 600/475, 600/476, 600/477
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/13 Tomography A61B8/10, A61B8/12 take precedence; tomography for radiation diagnosis A61B6/02

Abstract

A method for diagnosing malignancy in a tumor. A waveform representative of pulsatile blood flow in the tumor is measured, and the post-systolic portion of the wave form is fit with a mathematical function such as an exponential decay curve. A decay constant greater than about 48 pixels is diagnostic of malignancy.

Claims

1. A method for diagnosing a tumor, the method comprising the steps of:

(a) measuring a blood-flow waveform associated with the tumor, said waveform depicting pulsations of blood-flow associated with the tumor, said pulsations having systolic and diastolic components;

(b) fitting a post-systolic portion of said blood-flow waveform to a parameterized monotonic mathematical function; and

(c) inferring a likelihood of malignancy of said tumor from a parameter of said monotonic mathematical function.

2. The method of claim 1, further comprising the step of deriving said waveform from a measurement of a hemodynamic variable selected from the group consisting of blood velocity, blood pressure and blood flow rate.

3. The method of claim 2, wherein said hemodynamic variable is measured by a measurement technique selected from the group consisting of Doppler techniques, ultrasound techniques, Magnetic Resonance Imaging techniques, electromagnetic flow measurement techniques and intravascular catheterization techniques.

4. The method of claim 1, wherein said parameterized monotonic mathematical function is an exponential decay curve.

5. The method of claim 1, wherein said parameter of said monotonic mathematical function is a decay constant.

6. A method for diagnosing a pelvic tumor, the method comprising the steps of:

(a) measuring a blood-flow waveform associated with the pelvic tumor, said waveform dipicting pulsations of blood-flow associated with the pelvic tumor, said pulsations having systolic and diastolic components;

(b) fitting a post-systolic portion of said blood-flow waveform to a parameterized monotonic mathematical function; and

(c) inferring a likelihood of malignancy of said pelvic tumor from a parameter of said monotonic mathematical function.

7. The method of claim 6, further comprising the step of deriving said waveform from a measurement of a hemodynamic variable selected from the group consisting of blood velocity, blood flow rate, and blood pressure.

8. The method of claim 7, wherein said hemodynamic variable is measured by a measurement technique selected from the group consisting of Doppler techniques, ultrasound techniques, Magnetic Resonance Imaging techniques, electromagnetic flow measurement techniques and intravascular catheterization techniques.

9. The method of claim 6, wherein said parameterized monotonic mathematical function is an exponential decay curve.

10. The method of claim 6, wherein said parameter of said monotonic mathematical function is a decay constant.

11. A system for diagnosing a tumor, the system comprising:

(a) a mechanism for obtaining a pulsatile waveform for blood-flow associated with the tumor, said waveform having systolic and diastolic components to each pulsation,

(b) a mechanism for fitting a post-systolic portion of said blood-flow waveform to a parameterized monotonic mathematical function; and

(c) a mechanism for determining a parameter of said parameterized monotonic mathematical function, said parameter describing a likelihood of malignancy of said tumor.

12. The system of claim 11, wherein the mechanism for obtaining said blood-flow waveform includes a device selected from the group consisting of Doppler devices, ultrasound devices, Magnetic Resonance Imaging scanners, electromagnetic flow measurement devices and intravascular catheterization devices.

13. The system of claim 11, wherein the mechanism for fitting said post-systolic portion of said blood-flow waveform to said parameterized monotonic mathematical function includes a border detection algorithm.

14. A system for diagnosing a pelvic tumor, comprising:

(a) a mechanism for obtaining a pulsatile waveform for blood-flow associated with the pelvic tumor, said waveform having systolic and diastolic components to each pulsation;

(b) a mechanism for fitting a post-systolic portion of said blood-flow waveform to a parameterized monotonic mathematical function; and

(c) a mechanism for determining a parameter of said parameterized monotonic mathematical function, said parameter describing a likelihood of malignancy of said pelvic tumor.

15. The system of claim 14, wherein the mechanism for generating said blood-flow waveform includes a device selected from the group consisting of Doppler devices, ultrasound devices, Magnetic Resonance Imaging scanners, electromagnetic flow measurement devices and intravascular catheterization devices.

16. The system of claim 14, wherein the mechanism for fitting the post-systolic portion of said blood-flow waveform to said parameterized monotonic mathematical function is a border detection algorithm.