Recombinant adenovirus
First Claim
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1. A recombinant adenovirus comprising a genome with a deficiency in the E1 region, a gene encoding a functional adenoviral DNA polymerase, and a mutation in the major late promoter such that said major late promoter is attenuated within a cell other than a packaging cell.
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Abstract
The present invention provides a recombinant adenovirus having a genome with a deficiency in the E1 region and a mutation in the MLP. The invention also provides stocks of such viruses and compositions including the inventive viruses. The invention also provides cell lines for propagating the recombinant adenoviruses.
116 Citations
16 Claims
- 1. A recombinant adenovirus comprising a genome with a deficiency in the E1 region, a gene encoding a functional adenoviral DNA polymerase, and a mutation in the major late promoter such that said major late promoter is attenuated within a cell other than a packaging cell.
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14. A recombinant cell line, which produces adenoviral E1 gene products and a mutant form of the TATA-binding protein that recognizes a mutant TATA sequence.
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15. A recombinant cell line, which produces adenoviral E1 gene products and the NF-AT1 gene product.
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16. A recombinant cell line, which produces adenoviral E1 and L1-L5 gene products.
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