Method and apparatus for electrical stimulation of the gastrointestinal tract

• US 6,115,635 A
• Filed: 03/31/1999
• Issued: 09/05/2000
• Est. Priority Date: 12/15/1997
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Bourgeois, Ivan
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/282,184
• Time in Patent Office: 524 Days
• Field of Search: 607/40
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

A method and apparatus for providing electrical stimulation of the gastrointestinal tract. The apparatus features an implantable pulse generator which may be coupled to the gastric system through one or more medical electrical leads. In the preferred embodiment the leads couple to the circular layer of the stomach. The pulse generator preferably features sensors for sensing gastric electrical activity, and in particular, whether peristaltic contractions as occurring. One embodiment particularly solves the problem of accurately detecting gastric arrhythmias by periodically reverting into a sensed intrinsic gastric rhythm mode. In this mode the output of electrical stimulation is adjusted to only occur at an exceedingly slow rate. This slow rate of stimulation thus permits the gastro-intestinal tissues to undergo an intrinsic depolarization so that the underlying intrinsic slow wave rate may be detected.

Claims

1. An apparatus for providing electrical stimulation to the gastrointestinal tract comprising:

means for electrically coupling to the gastrointestinal tract;

a pulse generator coupled to the means for electrically coupling to the gastrointestinal tract, the pulse generator emitting stimulation pulse trains at a first rate;

means for periodically inhibiting the emission of stimulation pulse trains at the first rate and emitting stimulation pulse trains at a second rate, the second rate slower than the first rate; and

means for sensing slow wave gastrointestinal electrical activity, the slow wave sensor coupled to the means for electrically coupling to the gastrointestinal tract, the slow wave sensor emitting a slow wave gastrointestinal electrical activity signal upon the sensing of slow wave gastrointestinal electrical activity within a preset frequency range.

2. The apparatus of claim 1 further comprising means responsive to the sensing means for adjusting the first rate.

3. The apparatus of claim 1 wherein the means for sensing slow wave gastrointestinal electrical activity further comprise means for sensing tachygastric activity, the means for sensing tachygastric activity emitting a tachygastric activity signal upon the sensing of intrinsic tachygastric activity.

4. The apparatus of claim 3 wherein the pulse generator further comprises tachygastric stimulation means for emitting tachygastric stimulation in response to the emission of the tachygastric activity signal.

5. The apparatus of claim 4 wherein the tachygastric stimulation means emits tachygastric stimulation at a rate greater than a rate of the tachygastria activity signal.

6. The apparatus of claim 1 wherein the pulse trains emitted at the first rate comprises a pulse train, the pulse train having an amplitude, a pulsewidth and an inter pulse interval.

7. The apparatus of claim 6 wherein the interpulse interval is between approximately 6-600 ms in length.

8. The apparatus of claim 7 wherein the interpulse interval is approximately 60 ms.

9. The apparatus of claim 6 wherein the amplitude is between approximately 1-50 milliamps.

10. The apparatus of claim 9 wherein the amplitude is approximately 5 milliamps.

11. The apparatus of claim 6 wherein the pulsewidth is between approximately 3-1000 microseconds.

12. The apparatus of claim 11 wherein the pulsewidth is approximately 330 microseconds.

13. The apparatus of claim 6 wherein the pulse train having between approximately 1-100 pulses.

14. An apparatus for providing electrical stimulation to the gastrointestinal tract comprising:

means for electrically coupling to the gastrointestinal tract;

a tachygastric sensor for sensing intrinsic tachygastric activity, the tachygastric sensor coupled to the means for electrically coupling to the gastrointestinal tract, the tachygastric sensor generating a tachygastric activity signal for transmission through the electrical coupling means upon the sensing of intrinsic tachygastric activity;

a non-tachygastric sensor for sensing intrinsic non-tachygastric activity, the non-tachygastric sensor coupled to the means for electrically coupling to the gastrointestinal tract, the non-tachygastric sensor generating a non-tachygastric activity signal for transmission through the electrical coupling means upon the sensing of intrinsic non-tachygastric activity;

a pulse generator coupled to the means for electrically coupling to the gastrointestinal tract, the pulse generator, in response to receiving the tachygastric activity signal through the electrical coupling means, emitting tachygastric stimulation pulse trains, the pulse generator, in response to receiving the non-tachygastric activity signal through the electrical coupling means, inhibiting the emission of tachygastric stimulation pulse trains.