Drug delivery arrangement

• US 6,116,233 A
• Filed: 02/28/1995
• Issued: 09/12/2000
• Est. Priority Date: 09/11/1992
• Status: Expired due to Term

• Current Assignee: Profile Drug Delivery Limited
• Original Assignee: Medic-Aid Limited
• Inventors: McGuinness, Kevin, Denyer, Jonathan Stanley Harold
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US08/396,277
• Time in Patent Office: 2,023 Days
• Field of Search: 128/200.14, 128/200.18, 128/203.12, 128/204.23, 128/204.26
• US Class Current: 128/200.18
• CPC Class Codes: A61M 11/002 by flow deviation causing inertial separation of transported particles
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2205/42 Reducing noise

Abstract

An arrangement for delivering a drug aerosol comprises a sensor (3) which detects turbulent air flow during inhalation and causes the nebulizer (8,9,10,11,12,13) to generate the aerosol only during the inhalation phase of the breathing cycle. Airflow is diverted from the sensor during exhalation.

Claims

1. A drug delivery arrangement for delivering a drug aerosol to the respiratory system of a patient, comprising:

a) duct means having a first inlet, the first inlet being open to the atmosphere, the duct means being arranged to convey from said first inlet an airstream inhaled by the patient;

b) nebulizer means communicating with said duct means and arranged to generate a drug aerosol in said airstream, said nebulizer means having a second external inlet for connection to a compressed air supply;

c) means for generating turbulence in said airstream due to inhalation by the patient;

d) a microphone selectively responsive to said turbulence due to inhalation to generate a control signal; and

e) control means coupled to said nebulizer means and responsive to said control signal to cause said nebulizer means to generate said aerosol selectively during said inhalation phase of the breathing cycle.

2. A drug delivery arrangement according to claim 1, which comprises a directional valve which is located in the path of and operated by said airstream and arranged to direct the airstream to said microphone during a predetermined phase of the breathing cycle.

3. A drug delivery arrangement according to claim 1, wherein the turbulence generating means comprises a chamber in which the microphone is located, the chamber having an aperture that is exposed to forward and reverse airflow of said airstream during the inhalation and exhalation phases of the breathing cycle and is so disposed that it responds selectively to either the forward or reverse airflow of said airstream, the aperture being approximately parallel to the axis of the airflow.

4. A drug delivery arrangement according to claim 1, wherein said control means is arranged to smooth the output of said microphone, to compare the instantaneous output of the microphone with the smoothed output of the microphone and to generate said control signal in response to the comparison of said outputs.

5. A drug delivery arrangement according to claim 1, wherein said control means is responsive to changes in the amplitude of the output of the microphone so as to mitigate the effects of continuous background noise.

6. A drug delivery arrangement according to claim 1, wherein said control means includes gating means which is arranged to inhibit the generation of said control signal unless said microphone generates an output signal for longer than a predetermined period.

7. A drug delivery arrangement according to claim 6, wherein said gating means includes a non-retriggerable monostable multivibrator and a retriggerable monostable multivibrator connected to a common input and having their outputs connected to respective inputs of a logic gate.

8. A drug delivery arrangement according to claim 1, wherein said microphone is coupled by a flexible tube to a further tube through which the patient breathes.

9. A method of delivering a drug aerosol to the respiratory system of a patient, comprising the steps of:

a) generating turbulence in an airstream inhaled by a patient;

b) selectively detecting said turbulence due to inhalation with a microphone and generating a control signal in response thereto; and

c) in response to said control signal selectively generating a drug aerosol in said airstream during the inhalation phase of a patient'"'"'s breathing cycle.

10. A method as claimed in claim 9, wherein said airstream is conveyed through a duct which has an inlet open to the atmosphere.