Metered dose inhaler agitator

• US 6,116,234 A
• Filed: 02/01/1999
• Issued: 09/12/2000
• Est. Priority Date: 02/01/1999
• Status: Expired due to Fees

• Current Assignee: Kos Life Sciences, Inc. (Abbvie Incorporated)
• Original Assignee: IEP Pharmaceutical Devices, Inc.
• Inventors: Jewett, Warren R, Genova, Perry A.
• Primary Examiner(s): Dawson, Glenn K.
• Application Number:
  US09/241,010
• Time in Patent Office: 589 Days
• Field of Search: 128/200.16, 128/200.14, 128/200.23, 128/203.12, 222/402.1, 366/108, 366/110-116, 366/241, 366/605, 239/102.2
• US Class Current: 128/200.23
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/001 using ultrasonic means
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08

Abstract

A metered dose inhaler including a mechanism for agitating the medicament formulation prior to its separation in a measured dose, for administration to a mammal, including a human. The separated dose is a homogeneous mixture of prescribed medicine in a fluid carrier.

Claims

1. An assembly for administration to the respiratory tract of a mammal orally or intranasally, a pharmaceutically active medication, which comprises;

(a) a hollow tube having

(i) a first open end adapted by size and configuration to receive an aerosol canister containing a plurality of unit doses of the medication;

(ii) a second open end adapted by size and configuration to couple with the oral or nasal cavities of a mammal;

(iii) a hollow defined by the tube wall between the first and second open ends;

(b) an aerosol canister having a top and a bottom and a metering valve on the canister top for the release of a predetermined dose of a contained medication for administration to a mammal, positioned in the first open end of the tube;

(c) means for the valved release of a unit dose of medication from the aerosol canister; and

(d) means for agitating the medication in the aerosol canister, whereby a homogeneous mixture of the aerosol is obtained for release.

2. The assembly of claim 1 wherein the means for agitating comprises acoustic pressure waves transmitted to the aerosol contents of the canister.

3. The assembly of claim 1 wherein agitation of the aerosol contents takes place during the valved release of a dose of the pharmaceutically active medication.

4. The assembly of claim 1 which further comprises as the means for agitating, a piezoelectric crystal mounted in the hollow of the tube, a power source and electrical means connecting the power source to the crystal, said crystal functioning to transmit acoustic pressure waves.

5. The assembly of claim 1, wherein the means for agitating functions upon operation of the means for valved release of a unit dose.

6. The assembly of claim 5, wherein the means for valved release comprises a spray-directing stem mounted in the hollow of the tube in alignment with the axis of the tube hollow.

7. An assembly for administration to the respiratory tract of a mammal orally or intranasally, a pharmaceutically active medication, which comprises;

(a) a hollow tube having

(i) a first open end adapted by size and configuration to receive an aerosol canister containing a plurality of unit doses of the medication;

(ii) a second open end adapted by size and configuration to couple with the oral or nasal cavities of a mammal;

(iii) a hollow defined by the tube wall between the first and second open ends;

(b) an aerosol canister having a top and a bottom and a metering valve on the canister top for the release of a predetermined dose of a contained medication for administration to a mammal, positioned in the first open end of the tube and movable from the first open end towards the second open end, along a line co-incident with the axis of the tube hollow;

(c) a spray-directing stem mounted in the tube hollow on an axial line co-incident with the axis of the tube hollow at a point between the first and second open ends, to receive the canister when moved from the first open end towards the second open end, whereby there occurs a valved release of a unit dose of medication from the canister;

(d) a piezoelectric crystal mounted in the tube hollow at a point to contact the canister when moved towards the second end; and

(e) electric circuit means connected to the piezoelectric crystal for energizing the crystal when in contact with the canister.