Inhalation device

• US 6,116,239 A
• Filed: 08/03/1998
• Issued: 09/12/2000
• Est. Priority Date: 08/07/1997
• Status: Expired due to Fees

• Current Assignee: Art Slutsky, George Volgyesi, Noe Zamel
• Original Assignee: Art Slutsky, George Volgyesi, Noe Zamel
• Inventors: Volgyesi, George
• Primary Examiner(s): WEISS, JOHN
• Application Number:
  US09/128,405
• Time in Patent Office: 771 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.21, 128/203.23
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows

Abstract

An inhalation device for use in delivering a powdered substance to a user, the inhalation device comprises a housing including a holding portion for holding the substance; an air entry passageway sized and configured to direct air entering the inhalation device at the portion and to fluidize the substance upon inhalation by the user; a hold-up chamber in flow communication with the holding portion for receiving the fluidized substance and maintaining the substance in a fluidized state during inhalation by the user; and an air exit passageway in flow communication with the hold-up chamber and adapted to deliver the substance to the user.

Claims

1. An inhalation device for use in delivering a powdered substance to a user, the inhalation device comprising:

a hold-up chamber having a bottom;

a holding portion adapted to hold the substance, said holding portion opening into said bottom of said hold-up chamber in flow communication therewith;

an air entry passageway having an inlet port open to an exterior of said device, an exit port and a cross-sectional flow area, said exit port positioned above and directed downwardly at said holding portion, said exit port opening into said hold-up chamber proximate said holding portion opening into said bottom of said hold-up chamber; and

an air exit passageway having a cross-sectional flow area greater than the cross-sectional flow area of said air entry passageway, said air exit passageway in flow communication with said hold-up chamber at a location spaced apart from said holding portion, said air exit passageway adapted to deliver the substance to the user;

whereby air enters said air entry passageway from said exterior of the device and is directed downwardly through said exit port of said air entry passageway at the holding portion so as to fluidize the substance upon inhalation by the user, and whereby said substance is maintained in a fluidized state in said hold-up chamber during inhalation and thereafter delivered to the user through said air exit passageway.

2. The inhalation device of claim 1 comprising a plurality of air entry passageways, said plurality of air entry passageways having a combined cross-sectional flow area less than the cross-sectional flow area of said air exit passageway.

3. The inhalation device of claim 1 wherein said hold-up chamber has a circular cross-section.

4. The inhalation device of claim 3 wherein said hold-up chamber has a longitudinally extending axis about which the substance is adapted to swirl in a fluidized state.

5. The inhalation device of claim 4 wherein said holding portion has a longitudinally extending axis parallel to and spaced apart from said longitudinal axis of said hold-up chamber.

6. The inhalation device of claim 4 wherein said hold-up chamber has a cylindrically shaped portion surrounding said longitudinal axis and a frusto-conically shaped portion extending from said cylindrical portion, said holding portion communicating with a bottom of said frusto-conically shaped portion.

7. The inhalation device of claim 4 wherein at least a portion of said air exit passageway is non-parallel to said longitudinal axis.

8. The inhalation device of claim 4 wherein said holding portion is positioned adjacent one end of said hold-up chamber and said exit passageway is longitudinally displaced from said holding portion adjacent the other end of said hold-up chamber.

9. The inhalation device of claim 2 wherein said holding portion has a longitudinally extending axis, and wherein the exit port of at least one of said air entry passageways is offset from said longitudinal axis of said holding portion.

10. The inhalation device of claim 1 wherein said ratio of said cross-sectional flow area of said exit passageways to said cross-sectional flow area of said entry passageway is greater than or equal to 10:

1.

11. The inhalation device of claim 2 wherein at least one of said plurality of said air entry passageways directs air within the chamber to create a cyclonic flow therein.

12. The inhalation device of claim 1 further comprising a container having a plurality of holding portions, each of said holding portions adapted to hold a dose of substance, said container moveably connected to said chamber wherein said container can be moved to successively place at least one of said holding portions in communication with said hold-up chamber.

13. The inhalation device of claim 2 wherein said plurality of said air entry passageways comprises four air entry passageways.

14. The inhalation device of claim 1 wherein said holding portion is elongated and wherein said air entry passageway is positioned so as to direct air parallel to the length of said holding portion.

15. The inhalation device of claim 14 comprising a plurality of holding portions arranged circumferentially around a portion of said device, wherein said holding portions are radially elongated around said circumference of said portion of said device.

16. An inhalation device for use in delivering a powdered substance to a user, the inhalation device comprising:

a hold-up chamber having a longitudinal axis about which the substance is adapted to swirl in a fluidized state;

a holding portion adapted to hold the substance and opening into said hold-up chamber in flow communication therewith;

at least one air entry passageway in flow communication with said hold-up chamber and open to an exterior of said device, said air entry passageway adapted to introduce air into said hold-up chamber; and

an air exit passageway having at least a portion non-parallel to the longitudinal axis of said hold-up chamber, said air exit passageway in flow communication with said hold-up chamber and adapted to deliver the substance to the user.

17. The inhalation device of claim 16 wherein said air exit passageway is substantially perpendicular to said longitudinal axis of said hold-up chamber.

18. The inhalation device of claim 16 wherein said air exit passageway comprises an entry port and an exit port, said entry port opening into said hold-up chamber.

19. The inhalation device of claim 16 wherein said air entry passageway and said air exit passageway each have a cross-sectional flow area, said cross-sectional flow area of said air entry passageway being less than said cross-sectional flow area of said air exit passageway.

20. The inhalation device of claim 19 comprising a plurality of air entry passageways, said plurality of air entry passageways having a combined cross-sectional flow area less than the cross-sectional flow area of said air exit passageway.

21. The inhalation device of claim 16 wherein said hold-up chamber has a circular cross-section.

22. The inhalation device of claim 21 wherein said hold-up chamber has a cylindrically shaped portion centered about said longitudinally extending axis.

23. The inhalation device of claim 22 wherein said hold-up chamber has a frusto-conically shaped portion extending from said cylindrical portion, said holding portion communicating with a bottom of said frusto-conically shaped portion.

24. The inhalation device of claim 16 wherein said holding portion is positioned adjacent one end of said hold-up chamber and said air exit passageway is longitudinally displaced from said holding portion adjacent the other end of said hold-up chamber.

25. The inhalation device of claim 20 wherein at least one of said plurality of said air entry passageways directs air within the hold-up chamber to create a cyclonic flow therein.

26. The inhalation device of claim 16 further comprising a container having a plurality of holding portions, each of said holding portions adapted to receive a dose of medicament, said container moveably connected to said hold-up chamber wherein said container can be moved to successively place at least one of said holding portions in communication with said hold-up chamber.

27. An inhalation device for use in delivering a powdered substance to a user, the inhalation device comprising:

a hold-up chamber having a cross-sectional area and a bottom;

a holding portion adapted to hold the substance, said holding portion opening into said bottom of said hold-up chamber so as to be in flow communication therewith;

an air entry passageway open to an exterior of said device and having an exit port and a flow cross-sectional area, said exit port positioned above and directed downwardly at said holding portion so as to direct air entering the inhalation device at the holding portion and to fluidize the substance upon inhalation by the user, said exit port opening into said hold-up chamber proximate said holding portion opening into said bottom of said hold-up chamber; and

an air exit passageway having a flow cross-sectional area greater than the flow cross-section area of said air entry passageway and less than the cross-section area of said hold-up chamber, said exit passageway in flow communication with the hold-up chamber, said exit passageway adapted to deliver the substance to the user.

28. The inhalation device of claim 27 comprising a plurality of air entry passageways, said plurality of air entry passageways having a combined cross-sectional flow area less than the cross-sectional flow area of said air exit passageway.

29. The inhalation device of claim 27 wherein said hold-up chamber has a circular cross-section.

30. The inhalation device of claim 27 wherein said hold-up chamber has a longitudinally extending axis.

31. The inhalation device of claim 30 wherein said air exit passageway is non-parallel to said longitudinal axis of said hold-up chamber.

32. The inhalation device of claim 28 wherein at least one of said plurality of said air entry passageways directs air within the hold-up chamber to create a cyclonic flow therein.

33. The inhalation device of claim 27 further comprising a container having a plurality of holding portions, each of said holding portions adapted to receive a dose of substance, said container moveably connected to said hold-up chamber wherein said container can be moved to successively place at least one of said holding portions in communication with said hold-up chamber.

34. An inhalation device for use in delivering a powdered substance to a user, the inhalation device comprising:

a hold-up chamber having a longitudinal axis about which the substance is adapted to swirl in a fluidized state and a bottom;

a holding portion adapted to hold the substance, said holding portion opening into said bottom of said hold-up chamber so as to be in flow communication therewith;

a first air entry passageway open to an exterior of said device and having an exit port and a cross-sectional flow area, said exit port positioned above and directed downwardly at said holding portion so as to direct air entering the inhalation device at the holding portion and to fluidize the substance upon inhalation by the user;

a second air entry passageway having an exit port and a cross-sectional flow area, said exit port of said second air entry passageway positioned above said holding portion and directed substantially perpendicular to the longitudinal axis of the hold-up chamber at a location spaced from the holding portion; and

an air exit passageway having a flow cross-sectional area greater than the combined cross-section flow areas of said first and second air entry passageways, said air exit passageway in flow communication with the hold-up chamber and adapted to deliver the substance to the user.

35. A method for delivering a powdered substance to a user, said method comprising:

providing an inhalation device having an exterior and comprising a holding portion with a nominal dosage of said substance disposed thereon, a hold-up chamber in flow communication with said holding portion, said holding portion opening into a bottom of said hold-up chamber, an air entry passageway in flow communication with said hold-up chamber, said air entry passageway comprising an inlet port open to said exterior of said device and an exit port positioned above and directed downwardly at said holding portion, said exit port opening into said hold-up chamber proximate said holding portion opening into said bottom of said hold-up chamber, and an air exit passageway in flow communication with said hold-up chamber at a location spaced from said holding portion;

fluidizing said substance by inhaling through said air exit passageway and thereby directing air through said air entry passageway at a first velocity at said holding portion, wherein said air directed through said air entry passageway is generated solely by said inhaling through said air exit passageway;

maintaining said substance in a fluidized state in said hold-up chamber by swirling said fluidized substance within said hold-up chamber;

delivering an emitted dose of said fluidized substance to said user at a second velocity through said air exit passageway in flow communication with said hold-up chamber, wherein said second velocity is less than said first velocity.

36. The method of claim 35 wherein said first velocity is greater than or equal to about 40 km/hr.

37. The method of claim 35 wherein said second velocity is less than or equal to about 10 km/hr.

38. The method of claim 35 wherein said ratio of said nominal dose to said emitted dose is between about 2:

1 and about 1;

1.

39. The method of claim 35 wherein said inhalation device comprises a plurality of said air entry passageways, said plurality of air entry passageways having a combined cross-sectional flow area less than a cross-sectional flow area of said air exit passageway.

40. The method of claim 35 wherein said hold-up chamber has a longitudinal axis, and wherein said maintaining said medication in a fluidized state comprises swirling said substance about said longitudinal axis.

41. The method of claim 40 wherein at least a portion of said hold-up chamber has a circular cross-section and wherein at least one of said air entry passageways is directed tangentially to said circular cross-section so as to create a cyclonic flow in said hold-up chamber about said longitudinal axis.

42. The method of claim 35 wherein said hold-up chamber has a cylindrically shaped portion and a frusto-conically shaped portion extending from said cylindrical portion, said holding portion in flow communication with a bottom of said frusto-conically shaped portion.

43. The method of claim 40 wherein said air exit passageway is non-parallel to said longitudinal axis.

44. The method of claim 35 wherein said holding portion is positioned adjacent one end of said hold-up chamber and said air exit passageway is longitudinally displaced from said holding portion adjacent the other end of said chamber.