Method and apparatus for noninvasive assessment of a subject's cardiovascular system
First Claim
1. A method of deriving a physiological description of a cardiovascular system, the method comprising:
- a. obtaining a measurement sample associated with flow of the cardiovascular system, andb. utilizing a model that predicts, from first principles, measurement values associated with cardiovascular blood flow as a function of a plurality of source parameters, the model not being, an empirically-based construct, to derive a physiological description of the cardiovascular system in terms of at least one of the source parameters, wherein the model is at least one of (i) distributed and (ii) non-linear.
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Abstract
A method and apparatus for deriving a physiological description and clinically-useful data reboarding the cardiovascular system of an individual subject. The method includes obtaining a measurement sample associated with cardiovascular flow and utilizing a model, which may be distributed and/or non-linear to derive a description and data. The model generates and uses functions of source parameters and may, in an embodiment, match measurement samples against a library of stored predicted samples. A best-matching, predicted sample may then be associated with a measurement sample. An apparatus is provided which, according to an embodiment, includes an input for obtaining a measurement sample, a processor to derive the description and data, and an output. The apparatus may also include a digital storage medium to store a library of predicted samples.
145 Citations
16 Claims
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1. A method of deriving a physiological description of a cardiovascular system, the method comprising:
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a. obtaining a measurement sample associated with flow of the cardiovascular system, and b. utilizing a model that predicts, from first principles, measurement values associated with cardiovascular blood flow as a function of a plurality of source parameters, the model not being, an empirically-based construct, to derive a physiological description of the cardiovascular system in terms of at least one of the source parameters, wherein the model is at least one of (i) distributed and (ii) non-linear.
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2. A method of deriving a physiological description of a cardiovascular system, the method comprising:
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a. obtaining a measurement sample associated with flow of the cardiovascular system, b. matching the measurement sample against a library of stored predicted samples, each predicted sample derived from first principles from a model of the cardiovascular system and associated with a set of source parameter values, the model not being an empirically-based construct, the set having at least one source parameter value, to identify a best-matching predicted sample, and c. associating the measurement sample with the set that is associated with the best-matching, predicted sample. - View Dependent Claims (3, 4, 5, 6, 7, 8)
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9. An apparatus for deriving a physiological description of a cardiovascular system, the apparatus comprising:
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a. input means for receiving a measurement sample associated with flow of the cardiovascular system; b. processor means coupled to the input means and utilizing a model that predicts, from first principles, measurement values associated with cardiovascular blood flow as a function of a plurality of source parameters, the processor means for deriving the value of at least one source parameter pertinent to a physiological description of the cardiovascular system, wherein the model is at least one of (i) distributed and (ii) non-linear and is not an empirically-based construct; and c. output means for specifying the value of the at least one source parameter.
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10. An apparatus for deriving a physiological description of a cardiovascular system, the apparatus comprising:
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a. input means for receiving a measurement sample associated with flow of the cardiovascular system; b. digital storage means for storing a library of predicted samples, each predicted sample derived from first principles from a model of the cardiovascular system and associated with a set of source parameter values, the model not an empirically-based construct, the set having at least one source parameter value; c. processor means coupled to the input means and having access to the digital storage means for matching the measurement sample against the library of predicted samples to identify a best-matching predicted sample; and d. output means for identifying at least one member of the set of source parameter values associated with the best-matching predicted sample. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification