Device for delivering defined volumes
First Claim
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1. A liquid dispensing device for delivering defined volumes of a liquid comprising:
- (a) a reagent fill channel of first cross-sectional dimensions;
(b) one or more metering capillaries of second cross-sectional dimensions(i) connected to the reagent fill channel, and(ii) having an exit; and
(c) one or more sources of gas connected to the reagent fill channel,wherein the first cross-sectional dimensions are such that after the one or more metering capillaries are filled from the reagent fill channel, the reagent fill channel is drained of liquid without applying a pressure effective to drain liquid in the one or more metering capillaries, and wherein the source of gas is adapted to apply pressure to eject the liquid in the metering capillaries; and
wherein a metered amount of liquid is dispensed by said ejection.
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Abstract
Provided is a liquid dispensing device for delivering defined volumes comprising (a) a reagent fill channel, (b) one or more metering capillaries connected to the reagent fill channel and having an exit, and (c) one or more sources of gas connected to the reagent fill channel, wherein after filing the one or more metering capillaries the reagent fill channel can be drained of liquid while liquid is retained in the one or more metering capillaries, and the source of gas can be operated to eject the liquid in the metering capillaries.
93 Citations
18 Claims
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1. A liquid dispensing device for delivering defined volumes of a liquid comprising:
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(a) a reagent fill channel of first cross-sectional dimensions; (b) one or more metering capillaries of second cross-sectional dimensions (i) connected to the reagent fill channel, and (ii) having an exit; and (c) one or more sources of gas connected to the reagent fill channel, wherein the first cross-sectional dimensions are such that after the one or more metering capillaries are filled from the reagent fill channel, the reagent fill channel is drained of liquid without applying a pressure effective to drain liquid in the one or more metering capillaries, and wherein the source of gas is adapted to apply pressure to eject the liquid in the metering capillaries; and
wherein a metered amount of liquid is dispensed by said ejection. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 17)
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13. A liquid dispensing device for delivering defined volumes of a liquid comprising:
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(a) a reagent fill channel; (b) one or more metering capillaries (i) connected to the reagent fill channel, and (ii) having an exit, wherein a structure forming at least one of the metering capillaries forms a mesa into the reagent fill channel, or a mesa at the exit, or forms mesas into the reagent fill channel and at the exit; and (c) one or more sources of gas connected to the reagent channel, wherein after filling the one or more metering capillaries, the reagent fill channel is adapted to drain of liquid while liquid is retained in the one or more metering capillaries and wherein the source of gas is adapted to apply pressure to eject the liquid in the metering capillaries. - View Dependent Claims (14, 15, 16, 18)
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Specification