Antisense oligonucleotide inhibition of ras
First Claim
1. An oligonucleotide 8 to 30 nucleotides in length which is targeted to a nucleic acid encoding human H-ras and which is capable of inhibiting H-ras expression, wherein said oligonucleotide comprises SEQ ID NO:
- 1, 2, 3, 4, 5, 7, 11, 12, 13, 14 or 15.
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Abstract
Compositions and methods are provided for the modulation of ras expression. Oligonucleotides are provided which are targeted to nucleic acids encoding human ras. Oligonucleotides specifically hybridizable with mRNA encoding human H-ras, Ki-ras and N-ras are provided. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of activated ras. Methods for diagnosis, detection and treatment of conditions associated with ras are also disclosed.
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Citations
16 Claims
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1. An oligonucleotide 8 to 30 nucleotides in length which is targeted to a nucleic acid encoding human H-ras and which is capable of inhibiting H-ras expression, wherein said oligonucleotide comprises SEQ ID NO:
- 1, 2, 3, 4, 5, 7, 11, 12, 13, 14 or 15.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An oligonucleotide 8 to 30 nucleotides in length which is targeted to a nucleic acid encoding human Ki-ras and which is capable of inhibiting Ki-ras expression, wherein said oligonucleotide comprises SEQ ID NO:
- 20, 21, 22, 26, 28, 31 or 32.
- View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
Specification